Translator Red Knowledge (TReK)

翻译者红色知识（TReK）

• 批准号: 10333460
• 负责人: Michel Dumontier
• 金额: $ 49.92万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-23 至 2022-01-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10333460
• 关键词: Address; Administrator; Businesses; Clinical; Communication; Conflict (Psychology); Development; Disputes; Electronic Mail; Ensure; Exposure to; Friends; Funding; Goals; Grant; Institutes; Institution; Intellectual Property; Internet; Joints; Knowledge; Leadership; Licensing; Location; Methods; Outcome; Output; Patients; Performance; Persons; Policies; Preparation; Procedures; Progress Reports; Provider; Research Design; Research Project Grants; Research Support; Resolution; Resources; Telephone; Universities; Work; authority; conflict resolution; data analysis pipeline; data translator; disorder subtype; knowledge graph; learning strategy; meetings; open source; open source tool; organizational structure; programs; success; symposium; vector

Rationale: The goals of this application will be most effectively and efficiently met with a multiple PI plan. Drs. Weng, Dumontier, and Ta are recognized leaders in their fields and are excellent choices to ensure that the goals of the project are carried out in the most effective manner possible. Governance and Organization Structure: Drs. Weng, Dumontier, and Ta will share leadership equally for the project and each will take responsibility for specific organizational functions. Specifically, Dr. Weng will serve as the Contact PI. While all portions of the project will have input from all PIs, primary responsibilities will be split as follows: Drs. Weng and Ta will jointly oversee the following tasks: 1) all enhancements of the COHD data analysis pipeline and COHD API, including temporal analyses, processing clinical notes, and COHD replication studies; 2) development of representation learning methods for patient vector embedding and concept vector embedding, including downstream analyses like disease subtyping; and 3) creating the RCT PICO Knowledge Provider from output from the PICO NLP Parser. Dr. Dumontier will oversee the following tasks: 1) development and deployment of Data2Services; 2) development of the SPARQL Reasoner API interface to expose BioLink-compliant RDF as a Reasoner API; 3) development of user interfaces for querying and navigating knowledge graphs; and 4) management of the DSRI OpenShift cluster. Together, Drs. Weng, Dumontier, and Ta will oversee the preparation of the annual progress reports and other communications with the funding organization. PIs will work together to manage policy issues and to communicate with deans and other administrators to promote the success of the program. Communication Plan: While the PIs interact frequently in informal ways (at seminars, in other joint activities, and as colleagues and friends), they will also institute formal monthly web conferencing meetings to discuss study design and procedures, review milestones, interpret outcomes, and all administrative responsibilities. The PIs also plan to communicate frequently by e-mail, phone, and in person as issues arise that must be addressed promptly and also to review the success of initiatives and make programmatic adjustments as needed. Conflict Resolution: Conflicts will be resolved first through joint meetings between Drs. Weng, Dumontier and Ta. If a potential conflict develops, the appropriate departmental administrators representing the PIs shall meet and attempt in good faith to settle any dispute, claim or controversy arising out of or relating to the interpretation, performance or breach of this disagreement. However, if the departmental administrators fail to resolve the disagreement within thirty business days, then such disagreement shall be referred for resolution to a designated senior executive (e.g., deans) of the parties who has the authority to settle the disagreement but who is not directly involved in the disagreement. Intellectual Property: Since the NCATS Biomedical Data Translator program is principled on developing open-source tools, all products will be released with open-source licenses. Distribution of Resources: To the extent possible, the distribution of resources will be evenly divided between the two institutions (Columbia and Maastricht University) in line with the methods indicated in the application. Change in PI Location: If any PI moves to another institution, all possible attempts will be made to transfer the relevant portion of the grant to the new institution. If the new location is unable to accept or support the research project, then an alternative PI will be chosen to pursue that part of the project, if possible.

基本原理：此应用程序的目标将通过最有效和高效的 多重PI计划。翁博士、杜蒙蒂埃博士和塔博士是各自领域公认的领导者， 是确保项目目标在最大程度上实现的最佳选择 可能的有效方式。 治理和组织结构：翁博士、杜蒙蒂埃博士和塔博士将分享 平等地领导项目，每个人都将对特定的组织负责 功能。具体地说，翁博士将担任联系人PI。虽然项目的所有部分 将有来自所有绩效指标的投入，主要职责将划分如下： 翁博士和塔博士将共同监督以下任务：1)COHD的所有增强 数据分析流水线和COHD API，包括时间分析、处理临床记录、 和COHD复制研究；2)患者表征学习方法的发展 向量嵌入和概念向量嵌入，包括下游分析，如 疾病亚型；以及3)根据以下输出创建RCT Pico知识提供者 Pico NLP解析器。 杜蒙蒂埃博士将监督以下任务：1)制定和部署 Data2Services；2)开发SPARQL推理机API接口以公开符合Biolink的 RDF作为推理机API；3)开发用于查询和 导航知识图；以及4)DSRI OpenShift集群的管理。 翁博士、杜蒙蒂埃博士和塔博士将共同监督年度进展的准备工作 与资助组织的报告和其他沟通。 PIS将共同努力管理政策问题，并与院长和其他 管理员推动该计划的成功。 沟通计划：虽然私人投资机构经常以非正式方式互动(在研讨会、其他 联合活动，以及作为同事和朋友)，他们还将建立正式的月度网站 召开会议，讨论研究设计和程序，审查里程碑，解释 结果，以及所有行政责任。私家侦探还计划经常沟通 当出现必须迅速解决的问题时，通过电子邮件、电话和亲自发送到 审查计划的成功情况，并根据需要进行方案调整。 冲突解决：冲突将首先通过博士之间的联合会议来解决。 翁、杜蒙蒂埃和塔。如果发生潜在冲突，适当的部门 代表私人投资机构的管理人员应真诚地会面并试图解决任何纠纷， 因下列解释、履行或违反而引起或与之有关的索赔或争议 这种分歧。但是，如果部门管理员未能解决 在三十个工作日内不同意，则提交该不同意 向各方指定的高级管理人员(如院长)提交的决议 解决分歧，但谁没有直接参与分歧。 知识产权：由于NCATS生物医学数据翻译计划的原则是 开发开源工具，所有产品都将以开源许可证发布。 资源分配：在可能的范围内，资源分配将是均匀的 在两个机构(哥伦比亚大学和马斯特里赫特大学)之间划分，符合 申请中指明的方法。 更改PI位置：如果任何PI移动到另一个机构，所有可能的尝试都将 将补助金的相关部分转移到新的机构。如果新位置是 无法接受或支持研究项目，则将选择替代PI来 如果可能的话，继续项目的这一部分。