Rhode Island Hospital Injury Control Center for Biomedical Research Excellence (COBRE)

项目概要（总体） 伤害是1-44岁人群死亡的主要原因，导致3000多万例急诊 每年的部门访问1.我们非常需要更好的科学理解和战略， 与伤害流行病作斗争，但与其他主要原因相比，伤害控制研究资金不足。 死亡2，3.我们建议建立罗得岛医院伤害控制中心进行生物医学研究 卓越（COBRE）。拟议中的中心将是第一个也是唯一一个由NIH资助的COBRE研究中心， 专注于伤害控制。该提案的目标是建立和建设一个COBRE中心，以支持 项目研究负责人的研究活动，以确保他们过渡到独立资助的科学家。 这一目标将通过以下具体目标实现：1）建立核心（行政核心，伤害核心， 控制数字创新核心&伤害控制研究到实践和政策核心）需要发展和 维持一个主题性的多学科伤害控制卓越研究中心，并2）支持选择， 指导，并通过COBRE的研究和试点早期职业教师的职业发展 学习计划。RIH伤害控制COBRE研究将针对整个伤害谱 针对整个生命周期的个体（儿童、新生儿和老年人）进行预防（一级、二级、三级） 成人）。三个最初的RPL是三名女性初级教师，具有出色的潜力，使重要的 对伤害科学研究的贡献：Leslie Brick，PhD，Elizabeth Goldberg，MD，ScM和Stephanie Ruest， 医学博士公共卫生硕士此外，一个试点项目计划将支持未来初级研究人员的研究建议， 继续发展独立研究人员。这一指导试点计划将允许早期工作开始 在重要的伤害控制主题与创新研究，并允许这些项目进行，并成为后来 COBRE内部的研究项目或直接获得独立资助。RIH拥有强大的核心， 伤害控制科学领域的高级研究人员;然而，如果我们这样做，我们的研究人员管道将枯竭 没有扩大和补充有能力进行伤害控制研究的研究人员。RIH伤害控制 COBRE将汇集初级研究人员，高级教师和咨询委员会成员，建立一个中心 培养高水平的独立研究人员，以解决和改善重大负担 伤害对人口健康的影响。它将不断地进行严格的评估， 改进和准备我们的机构，以加快其高质量的创新伤害控制的生产 研究和研究人员。

PROJECT SUMMARY (Overall) Injury is the leading cause of death for individuals 1-44 years of age and contributes to over 30 million emergency department visits annually1. There is a tremendous need for greater scientific understanding and strategies to combat the injury epidemic yet injury control research is underfunded compared to other leading causes of death2,3. We propose to establish the Rhode Island Hospital Injury Control Center for Biomedical Research Excellence (COBRE). The proposed Center would be the first and only NIH-funded COBRE research center to focus solely on injury control. The objective of this proposal is to establish and build a COBRE Center to support the research activities of project research leaders to ensure their transition to independently funded scientists. This objective will be met through the following specific aims: 1) establish the cores (Administrative Core, Injury Control Digital Innovation Core & Injury Control Research to Practice and Policy Core) needed to develop and sustain a thematic multidisciplinary center of research excellence on injury control and to 2) support the selection, mentorship, and career development of early career faculty through the COBRE’s research studies and a pilot study program. The RIH Injury Control COBRE research studies will target the entire spectrum of injury prevention (primary, secondary, tertiary) with individuals across the lifecycle (children, emerging adults and older adults). The three initial RPLs are three women junior faculty with outstanding potential to make significant contribution to injury science research: Leslie Brick, PhD, Elizabeth Goldberg, MD, ScM and Stephanie Ruest, MD, MPH. In addition, a pilot project program will support research proposals for future junior investigators to continue the growth of independent researchers. This mentored pilot program will allow early work to commence on important injury control topics with innovative research and allow those projects to proceed and become later Research Projects within the COBRE or to progress directly to independent funding. RIH has a strong core of senior researchers in the field of injury control science; however, our pipeline of researchers will run dry if we do not expand and replenish researchers capable of injury control research excellence. The RIH Injury Control COBRE will bring together junior investigators, senior faculty and advisory committee members to build a center which produces high level, independent researchers equipped to address and improve the substantial burden injury has on population health. It will be continuously and rigorously evaluated allowing for constant improvement and preparing our institution to accelerate its production of high-quality innovative injury control research and researchers.