Evaluating State-Based Network Dynamics in Anhedonia

项目总结/摘要 快感缺失，即失去参与先前愉快活动的动力，与显著的 临床损伤重要的是，快感缺失与几种不同的精神疾病有关， 有希望的跨诊断治疗的机会。尽管其临床意义，快感缺乏是典型的 被忽视为主要治疗目标。因此，开发针对快感缺失的靶向治疗是 对人口心理健康至关重要。本提案旨在通过以下方式满足这一关键需求： 阐明跨诊断性快感缺失样本中的网络水平神经功能障碍，长期目标是 确定潜在的治疗目标。具体而言，拟议的项目将采取图形理论方法 具体目标如下：（1）建立脑网络分离和整合过程中， 奖励的预期预测快感缺失症状的严重程度，以及（2）评估网络中的变异性如何 当从休息过渡到奖励预期时的重新配置有助于快感缺失症状的严重性。 拟议的分析将利用已经收集的基线神经成像和NIMH的自我报告数据。 合同（#HHSN271201200006I; PI：Andrew Krystal，MD）。申请人的长期职业目标是进行 转化研究利用新的，transdiagnosis方法来检查奖励的神经指标， 加工及其相关的临床意义与发展机制驱动的总体目标 治疗。因此，拟议的项目将提供有指导的培训，其总体目标是深化 申请人的跨学科培训，弥合临床心理学和认知神经科学之间的差距。 具体培训目标包括：（1）广泛培训先进的脑网络分析技术和图形- 理论方法，（2）加强对快感缺乏相关循证临床研究的理解， (3)支持申请人的赠款写作和演讲技巧，以及建立她的出版记录，（4） 临床试验设计和管理方面的实践和应用培训，以及（5）进一步培训伦理问题， 心理学和负责任的研究行为。该培训计划和研究建议已 战略发展，以促进申请人的独立性，作为一个研究人员，并装备她的专业 跨学科技能，为她作为翻译研究员的成功职业生涯做好准备。

PROJECT SUMMARY/ABSTRACT Anhedonia, the loss of motivation to engage in previously enjoyable activities, is associated with significant clinical impairment. Importantly, anhedonia is implicated in several different psychiatric disorders, presenting a promising opportunity for transdiagnostic treatment. In spite of its clinical significance, anhedonia is typically overlooked as a primary treatment target. Consequently, developing targeted treatments for anhedonia is of critical importance for population mental health. The present proposal aims to address this critical need by clarifying network-level neural dysfunction in a transdiagnostic anhedonia sample, with the long-term goal of identifying potential treatment targets. Specifically, the proposed project will take a graph-theoretical approach to address the following specific aims: (1) establish how brain network segregation and integration during the anticipation of rewards predict anhedonic symptom severity, and (2) assess how variability in network reconfiguration when transitioning from rest to reward anticipation contributes to anhedonic symptom severity. The proposed analyses will utilize already collected baseline neuroimaging and self-report data from a NIMH contract (#HHSN271201200006I; PI: Andrew Krystal, MD). The applicant’s long-term career goal is to conduct translational research utilizing novel, transdiagnostic methods to examine the neural indices of reward- processing and their associated clinical implications with the overall target of developing mechanistically driven treatments. As such, the proposed project will provide mentored training with the overall goal of deepening the applicant’s interdisciplinary training, bridging the gap between clinical psychology and cognitive neuroscience. Specific training goals include: (1) extensive training in advanced brain network analytic techniques, and graph- theoretical approaches, (2) enhanced understanding of evidence-based clinical research relevant to anhedonia, (3) bolstering the applicant’s grant-writing and presentation skills as well as building her publication record, (4) practical and applied training in clinical trial design and management, and (5) further training in ethical issues in psychology and the responsible conduct of research. This training plan and research proposal have been strategically developed to foster the applicant’s independence as a researcher and equip her with a specialized interdisciplinary skillset to prepare her for a successful career as a translational researcher.