An integrated vascular MR imaging suite in brain diseases
脑部疾病的综合血管 MR 成像套件
基本信息
- 批准号:10330590
- 负责人:
- 金额:$ 56.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcetazolamideAlgorithmsAllergicBloodBlood VesselsBolus InfusionBrainBrain DiseasesBrain NeoplasmsBypassCarbon DioxideCategoriesCerebrovascular CirculationCerebrovascular DisordersCerebrovascular systemClinicalCollectionContrast MediaCross-Sectional StudiesDataData SetDevelopmentDiagnosisDiamoxDiseaseFunctional Magnetic Resonance ImagingFutureGadolinium DTPAGasesGlomerular Filtration RateGoalsImageInhalationInjectionsMagnetic Resonance ImagingMapsMeasurementMeasuresMedical ImagingMethodsMicrovascular DysfunctionMonitorMoyamoya DiseaseNeurologicNeurophysiology - biologic functionNeurosurgeonOperative Surgical ProceduresOutcomeParticipantPatientsPerformancePerfusionPharmaceutical PreparationsPhysiologic pulsePhysiologicalPlayPositron-Emission TomographyProceduresPropertyRadioactiveRadioisotopesReproducibilityResolutionRestRoleScanningStandardizationStenosisStratificationStress TestsStrokeSymptomsSystemTechniquesTechnologyTimeTraumatic Brain InjuryValidationVascular DementiaVendorVisitWorkautomated analysisbasebiomaterial compatibilitycare costscerebral blood volumecerebrovascularcerebrovascular healthcerebrovascular imagingclinical imagingclinical practicecloud basedcomputational platformcomputerized data processinghemodynamicsimaging modalityindexinginterestnervous system disorderneurosurgerynovelnovel strategiespredict clinical outcomeresearch studysingle photon emission computed tomographyspatiotemporaltoolweb site
项目摘要
Project Summary/Abstract:
Cerebrovascular imaging has a broad impact in a variety of brain disorders, including cerebrovascular
diseases such as stroke, arterial stenosis, Moymoya disease, small vessel diseases, and vascular dementia,
but also in other neurological conditions such as brain tumor and traumatic brain injury. Current clinical practice
of cerebrovascular imaging requires multiple scans and, in some cases, multiple visits in order to obtain a
complete assessment of the brain’s vascular health that includes perfusion, hemodynamic parameter, and flow
reserve. This limitation increases patient burden and significantly escalates the cost of care. Therefore, the
goal of the present project is to develop novel methods to perform an integrated vascular (iVas) imaging that
provides all relevant physiological information in a single scan (<10 minutes).
The proposed iVas-MRI technique will apply concomitant O2 and CO2 gas inhalation (but with different
timing) and will simultaneously measure cerebral blood volume (CBV), cerebrovascular reactivity (CVR), bolus
time-to-peak (TTP), and functional connectivity networks from the same dataset. Aim 1 will develop three key
components of the iVas-MRI technique, specifically concomitant O2 and CO2 gas-inhalation paradigm, high
spatial-resolution MRI pulse sequence, and multi-parametric data processing algorithm. A cloud-based
computation platform will also be developed for standardization of the analysis and future dissemination of the
technique. Aim 2 will conduct validation and multi-vendor assessment of the iVas-MRI technique. We will
compare results of the iVas-MRI technique to those of standard techniques and will examine across-vendor
reproducibility of the proposed technique by scanning each participant on three MRI systems manufactured by
General Electric, Philips, and Siemens, respectively. Aim 3 will apply the technique in patients with Moyamoya
disease and study its potential value in both the diagnosis and treatment monitoring of this condition. We will
first examine the utility of iVas-MRI in predicting clinical outcomes in a cross-sectional setting. Then, through
serial MRIs, we will examine the utility of iVas-MRI in differentiating treatment benefits of two most commonly
performed surgical procedures in Moyamoya patients, specifically direct versus indirect bypass surgery.
The long-term impact of this work on clinical practice is that patients with cerebrovascular diseases will
have their vascular imaging scan done in just one visit of less than 10 minutes (as opposed to multiple visits
and several scans). Additionally, patients who are allergic to conventional contrast agent will have access to an
alternative contrast agent (i.e. O2 and CO2 gases) for their vascular imaging needs.
项目概要/摘要:
脑血管成像在各种脑部疾病中具有广泛的影响,包括脑血管疾病
中风、动脉狭窄、Moymoya病、小血管疾病和血管性痴呆等疾病,
而且在其它神经病症如脑肿瘤和创伤性脑损伤中也是如此。当前临床实践
脑血管成像需要多次扫描,在某些情况下,需要多次访问,以获得
全面评估大脑血管健康状况,包括灌注、血流动力学参数和流量
保护区这种限制增加了患者负担,并显著增加了护理成本。因此
本项目的目标是开发新方法来执行集成血管(iVas)成像,
在一次扫描中提供所有相关的生理信息(<10分钟)。
所提出的iVas-MRI技术将应用伴随的O2和CO2气体吸入(但具有不同的
定时),并将同时测量脑血容量(CBV),脑血管反应性(CVR),推注
到达峰值的时间(TTP)和来自同一数据集的功能连接网络。目标1将制定三个关键
iVas-MRI技术的组成部分,特别是伴随O2和CO2气体吸入范例,
空间分辨率MRI脉冲序列和多参数数据处理算法。基于云的
还将开发一个计算平台,以使分析标准化,
法目标2将对iVas-MRI技术进行确认和多供应商评估。我们将
将iVas-MRI技术的结果与标准技术的结果进行比较,并将检查跨供应商
通过在三个MRI系统上扫描每名参与者,
通用电气、飞利浦和西门子。Aim 3将在烟雾病患者中应用该技术
并研究其在诊断和治疗监测这种情况的潜在价值。我们将
首先检查iVas-MRI在横截面设置中预测临床结果的实用性。然后通过
系列MRI,我们将检查iVas-MRI在区分两种最常见的
在烟雾病患者中进行外科手术,特别是直接与间接旁路手术。
这项工作对临床实践的长期影响是,脑血管疾病患者将
在不到10分钟的一次就诊中完成血管成像扫描(而不是多次就诊
几次扫描)。此外,对常规造影剂过敏的患者将可以获得
替代造影剂(即O2和CO2气体),以满足其血管成像需求。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hanzhang Lu其他文献
Hanzhang Lu的其他文献
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{{ truncateString('Hanzhang Lu', 18)}}的其他基金
ISMRM Workshop on Perfusion MRI: From Head to Toe
ISMRM 灌注 MRI 研讨会:从头到脚
- 批准号:
10391735 - 财政年份:2022
- 资助金额:
$ 56.22万 - 项目类别:
TRD1: Quantitative Imaging of Physiological Markers
TRD1:生理标志物的定量成像
- 批准号:
10614608 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
生理、代谢和解剖生物标志物的 MRI 资源
- 批准号:
10614604 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
生理、代谢和解剖生物标志物的 MRI 资源
- 批准号:
10439901 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
TRD1: Quantitative Imaging of Physiological Markers
TRD1:生理标志物的定量成像
- 批准号:
10439903 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
TRD1: Quantitative Imaging of Physiological Markers
TRD1:生理标志物的定量成像
- 批准号:
10270098 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
MRI Resource for Physiologic, Metabolic and Anatomic Biomarkers
生理、代谢和解剖生物标志物的 MRI 资源
- 批准号:
10270096 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
Blood-brain barrier dysfunction in Alzheimer's disease: from humans to animal models
阿尔茨海默病的血脑屏障功能障碍:从人类到动物模型
- 批准号:
10178195 - 财政年份:2021
- 资助金额:
$ 56.22万 - 项目类别:
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's disease
阿尔茨海默病血脑屏障通透性的非对比磁共振成像
- 批准号:
10621142 - 财政年份:2020
- 资助金额:
$ 56.22万 - 项目类别:
Non-contrast MR imaging of blood-brain-barrier permeability in Alzheimer's disease
阿尔茨海默病血脑屏障通透性的非对比磁共振成像
- 批准号:
10390475 - 财政年份:2020
- 资助金额:
$ 56.22万 - 项目类别:
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