The Paired Undergraduate Mentoring Program (PUMP) in Uronephrology

摘要 美国正面临着生物医学劳动力危机，进入美国的个人多样性不足加剧了这一危机 职业道路，从STEM专业本科培训的自然减员开始。结果是，特别是对 影响少数群体和未得到充分服务的人群的疾病，是缺乏创新的解决方案 提高健康结果。慢性肾脏疾病和终末期肾脏疾病对 非洲裔美国人和在美国代表着巨大的医疗和经济负担，每年 管理成本估计为1200亿美元。杜克大学在解决这一关键问题上处于独特的地位 通过建立一个强大的、多样化的和可持续的未来学术生物医学科学家的管道来解决这个问题。我们的 最近成立的医师科学家发展办公室(OPSD)为 导师、专业发展和研究资金。通过利用这种制度结构，我们正在 能够很好地支持开发、实施和评估链接资源的计划 通过各种培训向本科生介绍各种研究职业机会，同时 准备高级实习生过渡到教员职位，成为强大的独立调查人员，熟练于 指导来自不同背景的学生。为了解决生物医学劳动力缺口，我们建议 配对的本科生肾脏学导师计划(PUMP)，将招募不同的队列 本科生，并让他们接触研究技能建设和指导研究经验 泌尿科和肾脏科。我们会提供以证据为本的专业发展活动，目标是 学生参与者和学员将担任日常研究项目的导师。杜克泵 将实现我们的长期目标，解决限制招聘和留住多元化员工的障碍 通过密集的研究经验，结构化的三角指导，以及 持续的虚拟参与。该计划的重点是1)实施有指导的暑期研究 丰富计划，在不同的正在崛起的队列中培养对尿肾病学研究职业的兴趣 大三和大四的本科生；2)准备下一代尿沉降学研究人员，指导不同的 通过对研究生和博士后助理进行导师培训和提供 他们有领导学生研究项目的重要经验；以及3)准备一批多样化的本科生 用于研究生培训和通过持续的参与进入尿肾病学研究职业生涯， 扩展和丰富了暑期研究项目的经验。成功实施拟议的 该计划将导致一个可扩展的模型，用于为多样化的生物医学研究开发强大的管道 跨学科的员工队伍。

ABSTRACT The U.S. is facing a biomedical workforce crisis, exacerbated by insufficient diversity among individuals entering the career path, starting with attrition from STEM majors in undergraduate training. The result, particularly for diseases that disparately impact minority and underserved populations, is a lack of innovative solutions to advance health outcomes. Chronic kidney disease and end stage kidney disease disproportionately affect African Americans and represent a substantial medical and economic burden in the U.S., with annual management costs estimated at $120 billion. Duke University is uniquely positioned to address this critical problem by building a robust, diverse, and sustainable pipeline of future academic biomedical scientists. Our recently established Office of Physician Scientist Development (OPSD) offers a sustainable structure for mentorship, professional development, and research funding. By leveraging this institutional structure, we are well positioned to support the development, implementation, and evaluation of a program that links resources across the training spectrum to introduce undergraduate students to varied research career opportunities, while preparing senior trainees transitioning to faculty positions to become strong independent investigators skilled in mentoring students from diverse backgrounds. To address the biomedical workforce gap, we propose the Paired Undergraduate Mentoring Program (PUMP) in Uronephrology, which will recruit diverse cohorts of undergraduate students and expose them to research skills-building and mentored research experiences in urology and nephrology. We will provide evidence-based professional development activities targeting both the student participants and the trainees who will serve as the day-to-day research project mentors. Duke PUMP will achieve our long-term goal, addressing barriers that limit the recruitment and retention of a diverse uronephrology workforce, through intensive research experiences, structured triangular mentorship, and sustained virtual engagement. The program focuses on 1) implementing a mentored summer research enrichment program to develop interest in uronephrology research careers among a diverse cohort of rising junior and senior undergraduates; 2) preparing next-generation uronephrology investigators to mentor a diverse biomedical workforce by training graduate students and postdoctoral associates in mentorship and providing them critical experience leading student research projects; and 3) preparing a diverse cohort of undergraduates for post-graduate training and entry into uronephrology research careers through sustained engagement that extends and enriches the summer research program experience. Successful implementation of the proposed program will lead to a scalable model for development of a robust pipeline for a diverse biomedical research workforce across disciplines.