Core B: Outreach, Ascertainment, and Data Collection

核心 B：外展、确定和数据收集

• 批准号: 10333056
• 负责人: Margaret A. Pericak-Vance
• 金额: $ 387.91万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333056
• 关键词: Africa; African; African American population; Alzheimer' s Disease; American; Awareness; Biological; Biological Markers; Blood specimen; Clinical; Clinical Data; Collection; Country; DNA; Data; Data Collection; Dementia; Enrollment; Evaluation; Freezing; Future; Genetic Variation; Genetic study; Genotype; Goals; Hispanic; Individual; Infrastructure; Institutes; Latinx; Lead; Measures; Metadata; Methods; Modification; Motivation; Neurocognitive; Nigeria; Participant; Patients; Plasma; Population; Procedures; Process; RNA; Research Personnel; Resources; Sampling; Ships; Site; Tube; Universities; Work; adjudication; biobank; cohort; forest; genome sequencing; human genomics; member; neurocognitive test; outreach; phenotypic data; rare variant; recruit; whole genome

PROJECT SUMMARY/ABSTRACT: CORE B (Outreach, Ascertainment and Data Collection Core) The overall goal of Core B is to provide the infrastructure and support for the ascertainment and collection of phenotypic data and biological samples on 4000 African Americans (AA), 4000 Hispanic/Latinx Americans (HL) and 5000 Africans (AF) from the US and Africa. The phenotypic data gathered by Core B will sent to Core E and used for adjudication and harmonization by Core C, while the blood, plasma, and RNA samples collected by Core B will be sent to the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami (UM), used for DNA genotyping for Projects 1 and 2 and future WGS studies in FUS 2.0 and biomarkers and expression studies (Core D). The work of Core B will provide the necessary materials for both common and rare variant analysis and discovery in ancestral populations in the imputation studies in Projects 1 and 2. Specific Aim 1 will recruit and ascertain AA and HL participants in four US and nine AF sites. The AF sites are in eight different countries, all members of the African Dementia Consortium (AfDC). The University of Ibadan, Nigeria, will be the primary coordinating site for the other AfDC sites. We will ascertain ~13,000 individuals/participants (6,500 cases and 6,500 controls) consisting of AA (n=4,000), HL (n=4,000) and AF (n=5,000). Specific Aim 2. We will collect clinical, neurocognitive testing, blood samples and metadata on AA (n=4,000), HL (n=4,000) and AF (n=5,000) participants. Tubes for DNA, RNA and plasma will be collected. This study will provide a resource for future studies in AD in AA, AF and HL patients.

项目总结/摘要：核心B（外展、确认和数据收集核心） 核心B的总体目标是提供基础设施和支持，以确定和收集 4000名非裔美国人（AA）、4000名西班牙裔/拉丁裔美国人（HL）的表型数据和生物样本 以及来自美国和非洲的5000名非洲人（AF）。核心B收集的表型数据将发送至核心E 并用于核心C的裁定和协调，而采集的血液、血浆和RNA样本 核心B的基因将被送往迈阿密大学的约翰·P·胡斯曼人类基因组研究所（HIHG） (UM)，用于项目1和2的DNA基因分型以及FUS 2.0中未来的WGS研究和生物标志物， 表达研究（核心D）。核心B的工作将为普通和稀有提供必要的材料 在项目1和项目2的插补研究中，对祖先群体进行变异分析和发现。具体 目标1将在4个美国和9个AF研究中心招募和确定AA和HL参与者。AF站点有八个 非洲痴呆症联盟（AfDC）的所有成员。尼日利亚伊巴丹大学， 将是其他AfDC站点的主要协调站点。我们将确定约13，000名个人/参与者 （6，500例病例和6，500例对照），包括AA（n= 4，000）、HL（n= 4，000）和AF（n= 5，000）。具体目标2。 我们将收集AA（n= 4，000）、HL（n= 4，000）和HL（n= 4，000）的临床、神经认知测试、血液样本和元数据。 AF（n= 5，000）受试者。将采集DNA、RNA和血浆试管。这项研究将提供一个资源 用于AA、AF和HL患者中AD的未来研究。