Core A: Administrative Core

摘要 ReadD-ADSP提案的大量地点(14个)和国际性质使后勤， 监管和金融方面尤其复杂。核心A，管理核心，提供必要的 这项提案的监督、协调和行政基础设施。核心A将监督监管 以及我们国际合作的财务方面，并确保广泛的数据共享。适当的分享 收集的数据和样本需要执行若干机构协议和 确保适当的IRBs到位。核心A将确保所有文件都已签署并通过IRB 在样品转移之前已获得批准。一位经验丰富的财务总监将监督所有 财务方面，与各核心、项目和现场绩效指标密切互动和协作 不同的ReadD-ADSP机构。核心A将协调和集成所有ReadD-ADSP组件和 活动。在这样一项大规模的研究中，频繁的交流是必不可少的。每半个月举行一次电视会议 MPI和调查人员将由Core A组织和管理。Core A将协调和组织 内部执行和外部科学咨询委员会会议。的内部执行委员会 所有MPI将每隔一个月举行一次会议，审查进展情况并解决任何悬而未决的问题。一个外部的 由具有相关专业知识的个人组成的科学咨询委员会将每年举行四次会议(1/2)。 人员)提供反馈。核心A将支持这些会议，并确保任何建议都 实施。最后，核心A将促进与ReadD相关的科学界的互动-- ADSP的目标以及公众。只有当人们意识到一种资源时，它才有价值。核心A将提供帮助 调查员通过国家/国际会议、出版物和新闻稿宣传他们的工作 并通过开发一个网站。该网站还将包含面向非专业受众的信息， 包括研究经费和参与机会的重点。核心A还将与NIA对接以 随时向他们通报调查结果，并实施NIA要求的任何更改。

ABSTRACT The large number of sites (14) and the international nature of the READD-ADSP proposal make the logistical, regulatory and financial aspects particularly complex. Core A, the administrative core, provides the necessary oversight, coordination, and administrative infrastructure for this proposal. Core A will oversee the regulatory and financial aspects of our international collaboration and assure broad data sharing. The proper sharing of data and samples being collected necessitates the execution of a number of institutional agreements and assurance that the proper IRBs are in place. Core A will ensure that all documents have been signed and IRB approval has been obtained prior to the transfer of samples. An experienced Director of Finance will oversee all financial aspects, with close interaction and collaboration with the individual Core, Project and Site PIs at the different READD-ADSP institutions. Core A will coordinate and integrate all READD-ADSP components and activities. In a study this large, frequent communication is imperative. Semi-monthly video conferences of the MPIs and investigators will be organized and managed by Core A. Core A will coordinate and organize internal executive and external scientific advisory committee meetings. An internal executive committee of all the MPIs will meet every other month to review progress and address any outstanding issues. An external scientific advisory committee comprised of individuals with relevant expertise will meet four times a year (one in- person) to provide feedback. Core A will support these meetings and ensure that any recommendations are implemented. Lastly, Core A will facilitate the interaction with scientific communities relevant to READD- ADSP goals as well as the lay public. A resource is only valuable if people are aware of it. Core A will assist investigators with publicizing their work through national/international meetings, publications, and press releases and through the development of a website. The website will also contain information geared to the lay audience, including highlights of research funding and participation opportunities. Core A will also interface with NIA to keep them apprised of findings and to implement any changes that NIA requests.