Project 1: Genetic Discovery Within Diverse Ancestry Cohorts

项目总结 阿尔茨海默病的基因组学是复杂的，迄今的证据表明，不同的祖先群体 有明显的影响风险的遗传因素。在这个项目中，我们将对以下各项进行多项统计分析 在非裔美国人、非洲人和西班牙裔/拉丁裔人群中生成遗传数据，以确定遗传因素 在这些群体中是截然不同的。我们将开发和应用新的方法来识别监管要素 并利用混合染色体，这是这些种群的特征。最后，我们将对结果进行总结 通过多基因和途径分析来确定含有遗传变异的特定分子机制 影响这些人群中的阿尔茨海默氏症风险。

PROJECT SUMMARY The genomics of Alzheimer Disease is complex and evidence to date suggests that different ancestry groups have distinct genetic factors that influence risk. In this project, we will perform multiple statistical analyses of generated genetic data in African American, African, and Hispanic/Latinx populations to identify genetic factors that are distinct within those groups. We will develop and apply new methods for identifying regulatory elements and leveraging admixed chromosomes that are features of these populations. Finally, we will summarize results through polygenic and pathway analyses to identify specific molecular mechanisms that harbor genetic variants influence Alzheimer risk in each of these populations.