The Alzheimer's Disease Translational Data Science Training Program

阿尔茨海默病转化数据科学培训计划

• 批准号: 10686916
• 负责人: William S Bush
• 金额: $ 27.44万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686916
• 关键词: Alzheimer' s Disease; Data Science; Training Programs

PROJECT SUMMARY/ABSTRACT (DESCRIPTION) The Case Western Reserve University (CWRU) Alzheimer’s Disease Translational Data Science (ADTDS) Training Program is designed to power therapeutic discovery by producing a new generation of scientists cross- trained in clinical research of Alzheimer’s Disease (AD) and analysis of large scale ‘omics data. Focused on predoctoral PhD and MD PhD students, this training program fills a critical gap between these disciplines in academic graduate programs. The ADTDS builds upon the Cleveland Alzheimer’s Disease Research Center (CADRC), and multiple ongoing national collaborations responsible for generating large-scale multi-omic data on diverse populations with AD. As part of this training program, trainees will: 1) Form multi-disciplinary mentorship teams to expand understanding of AD etiology and disease course through data analysis, 2) Interact with a variety of faculty who are world-recognized leaders in AD genetics, pathology, and neuroscience, 3) Access large-scale data from national initiatives supported by NIA, including the ADSP, ADGC, ADNI, and AMP- AD, to answer translational and basic research questions, and 4) Receive specialized training in responsible conduct and research reproducibility with special considerations for data science. Our cross-disciplinary training program provides strong mentoring and uses state-of-the-art data science experiences within the rich environment of the CWRU School of Medicine and its affiliated hospital systems to develop independent investigators who will lead the next generation of translational research in Alzheimer’s Disease.

项目总结/摘要（描述） 凯斯西储大学（CWRU）阿尔茨海默病转化数据科学（ADTDS） 培训计划旨在通过培养新一代的科学家， 在阿尔茨海默病（AD）的临床研究和大规模组学数据分析方面接受过培训。专注于 博士前博士和MD博士生，这个培训计划填补了这些学科之间的关键差距， 学术研究生课程。ADTDS建立在克利夫兰阿尔茨海默病研究中心的基础上 （CADRC），以及负责生成大规模多组学数据的多个正在进行的国家合作 在不同的AD患者身上作为该培训计划的一部分，学员将：1）形成多学科 导师团队通过数据分析扩大对AD病因和病程的理解，2）互动 拥有世界公认的AD遗传学，病理学和神经科学领导者的各种教师，3） 访问来自NIA支持的国家计划的大规模数据，包括ADSP、ADGC、ADNI和AMP- AD，回答翻译和基础研究问题，以及4）接受专业培训，负责 进行和研究再现性与数据科学的特殊考虑。我们的跨学科培训 该计划提供强大的指导，并在丰富的 CWRU医学院及其附属医院系统的独立发展环境 研究人员将领导下一代阿尔茨海默病的转化研究。

项目成果

Genetic analysis of cognitive preservation in the midwestern Amish reveals a novel locus on chromosome 2.

对中西部阿米什人认知保存的遗传分析揭示了 2 号染色体上的一个新基因座。

• DOI: 10.1101/2023.12.13.23299932
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Main,LeighanneR;Song,YeunjooE;Lynn,Audrey;Laux,ReneeA;Miskimen,KristyL;Osterman,MichaelD;Cuccaro,MichaelL;Ogrocki,PaulaK;Lerner,AlanJ;Vance,JefferyM;Fuzzell,MDenise;Fuzzell,SaradaL;Hochstetler,SherriD;Dorfsman,Daniel
• 通讯作者: Dorfsman,Daniel