The Alzheimer's Disease Translational Data Science Training Program

项目摘要/摘要(说明) 西储大学(CWRU)阿尔茨海默病翻译数据科学(ADTDS) 培训计划旨在通过培养新一代科学家交叉 受过阿尔茨海默病(AD)临床研究和大规模组学数据分析方面的培训。专注于 博士后和医学博士研究生，这一培训计划填补了这些学科之间的关键空白 学术研究生课程。ADTDS建立在克利夫兰阿尔茨海默病研究中心的基础上 (CADRC)，以及负责生成大规模多组学数据的多个正在进行的国家合作 不同的阿尔茨海默病患者。作为本培训计划的一部分，学员将：1)形成多学科 导师团队通过数据分析扩大对AD病因和病程的了解，2)互动 拥有世界公认的AD遗传学、病理学和神经科学方面的领导者的各种教职员工，3) 访问由NIA支持的国家计划的大规模数据，包括ADSP、ADGC、ADNI和AMP- 回答翻译和基础研究问题，以及4)接受负责的专门培训 行为和研究的再现性，并特别考虑数据科学。我们的跨学科培训 计划提供强大的指导，并使用最先进的数据科学经验 CWRU医学院及其附属医院系统独立发展的环境 将领导下一代阿尔茨海默病翻译研究的研究人员。

PROJECT SUMMARY/ABSTRACT (DESCRIPTION) The Case Western Reserve University (CWRU) Alzheimer’s Disease Translational Data Science (ADTDS) Training Program is designed to power therapeutic discovery by producing a new generation of scientists cross- trained in clinical research of Alzheimer’s Disease (AD) and analysis of large scale ‘omics data. Focused on predoctoral PhD and MD PhD students, this training program fills a critical gap between these disciplines in academic graduate programs. The ADTDS builds upon the Cleveland Alzheimer’s Disease Research Center (CADRC), and multiple ongoing national collaborations responsible for generating large-scale multi-omic data on diverse populations with AD. As part of this training program, trainees will: 1) Form multi-disciplinary mentorship teams to expand understanding of AD etiology and disease course through data analysis, 2) Interact with a variety of faculty who are world-recognized leaders in AD genetics, pathology, and neuroscience, 3) Access large-scale data from national initiatives supported by NIA, including the ADSP, ADGC, ADNI, and AMP- AD, to answer translational and basic research questions, and 4) Receive specialized training in responsible conduct and research reproducibility with special considerations for data science. Our cross-disciplinary training program provides strong mentoring and uses state-of-the-art data science experiences within the rich environment of the CWRU School of Medicine and its affiliated hospital systems to develop independent investigators who will lead the next generation of translational research in Alzheimer’s Disease.