The Alzheimer's Disease Translational Data Science Training Program

阿尔茨海默病转化数据科学培训计划

• 批准号: 10475653
• 负责人: William S Bush
• 金额: $ 22.41万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475653
• 关键词: Alzheimer' s Disease; Data Science; Training Programs

PROJECT SUMMARY/ABSTRACT (DESCRIPTION) The Case Western Reserve University (CWRU) Alzheimer’s Disease Translational Data Science (ADTDS) Training Program is designed to power therapeutic discovery by producing a new generation of scientists cross- trained in clinical research of Alzheimer’s Disease (AD) and analysis of large scale ‘omics data. Focused on predoctoral PhD and MD PhD students, this training program fills a critical gap between these disciplines in academic graduate programs. The ADTDS builds upon the Cleveland Alzheimer’s Disease Research Center (CADRC), and multiple ongoing national collaborations responsible for generating large-scale multi-omic data on diverse populations with AD. As part of this training program, trainees will: 1) Form multi-disciplinary mentorship teams to expand understanding of AD etiology and disease course through data analysis, 2) Interact with a variety of faculty who are world-recognized leaders in AD genetics, pathology, and neuroscience, 3) Access large-scale data from national initiatives supported by NIA, including the ADSP, ADGC, ADNI, and AMP- AD, to answer translational and basic research questions, and 4) Receive specialized training in responsible conduct and research reproducibility with special considerations for data science. Our cross-disciplinary training program provides strong mentoring and uses state-of-the-art data science experiences within the rich environment of the CWRU School of Medicine and its affiliated hospital systems to develop independent investigators who will lead the next generation of translational research in Alzheimer’s Disease.

项目摘要/摘要（描述） 案例西部储备大学（CWRU）阿尔茨海默氏病转化数据科学（ADTDS） 培训计划旨在通过生产新一代科学家交叉来进行疗法的发现。 接受了对阿尔茨海默氏病临床研究（AD）的培训和大规模分析“ OMICS数据”。专注于 该培训计划填补了这些学科之间的关键差距 学术研究生课程。 ADTD建立在克利夫兰阿尔茨海默氏病研究中心 （CADRC）以及多次正在进行的国家合作，负责生成大规模多摩变数据 在潜水员种群上，有广告。作为该培训计划的一部分，学员将：1）形成多学科 通过数据分析扩大对AD病因和疾病课程的理解，2） 有各种各样的教师在广告遗传学，病理学和神经科学领域被世界认可的领导者，3） 访问NIA支持的国家计划的大规模数据，包括ADSP，ADGC，ADNI和AMP- 广告，回答翻译和基础研究问题，以及4）接受负责任的专业培训 对数据科学的特殊考虑进行和研究可重复性。我们的跨学科培训 计划提供强烈的心理，并在富人中使用最先进的数据科学经验 CWRU医学院及其会员医院系统的环境，以发展独立 将领导阿尔茨海默氏病的下一代转化研究的调查人员。