Vaccinology Training Program

疫苗学培训计划

• 批准号: 10333157
• 负责人: Robert Wilson Frenck
• 金额: $ 15.68万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-09 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333157
• 关键词: Training Programs; vaccinology

This is a new application for a T32 training program that will train the next generation of leaders in vaccine science. The Vaccinology Training Program (VTP) builds on a strong legacy of vaccine development at Cincinnati Children’s Hospital and the University of Cincinnati that includes the oral polio vaccine pioneered by Albert Sabin, the development of one of the world’s leading rotavirus vaccines by Drs. David Bernstein and Richard Ward, and the more recent evaluation of multiple COVID vaccines. Cincinnati Children’s is a longstanding site within the NIH-sponsored Vaccine and Treatment Evaluation Unit (VTEU) network, and features unique strengths in vaccine clinical trials including controlled human infection models (CHIMs) for evaluation of vaccines against Shigella sonnei, norovirus, cholera, and influenza; investigator-initiated trials for novel RSV vaccines, and application of systems vaccinology tools to elucidate the cellular/molecular pathways that lead to successful adaptive immune responses to vaccines in both young and aged individuals. Investigators in our program lead a large U01-funded cohort study of pregnant women and their infants studying the earliest responses to influenza infection and vaccination in order to understand the principles of immunologic imprinting. The VTP features outstanding basic science faculty pursuing a wide variety of projects relevant to vaccine development, including the areas of infectious disease pathogenesis, novel immunogen design, basic aspects of immune development and regulation, computational and functional genomics related to vaccines, and reproductive biology and immunology. The VTP will provide training to M.D., Ph.D., and MD-PhD postdoctoral researchers that will facilitate their development into successful independent investigators devoted to vaccine-relevant research. The program will support 4 trainees in the program per year, each appointed to 2-year terms. 22 expert mentors with strong track records in scientific mentorship and NIH-funded research programs will serve as the VTP mentors and faculty. Formal education in the breadth of vaccine sciences will be provided to all VTP trainees, including a seminar course in vaccinology covering bench-to-bedside aspects of vaccinology, formal education in grant writing, and targeted coursework relevant to the research project and focus (basic or translational) of individual trainees. Our program is dedicated to recruitment of trainees from diverse backgrounds, races, and ethnicities. The intended outcome is to nurture and develop VTP trainees into creative, independent scientists who will form the vaccinology workforce of the future.

这是T32培训计划的新应用，该计划将培训下一代疫苗领导者。 科学疫苗学培训计划（VTP）建立在疫苗开发的强大遗产之上， 辛辛那提儿童医院和辛辛那提大学开创了包括口服脊髓灰质炎疫苗在内的 由阿尔伯特·萨宾（Albert Sabin）开发，由大卫（David伯恩斯坦）博士开发的世界领先的轮状病毒疫苗 和理查德·沃德，以及最近对多种COVID疫苗的评估。辛辛那提儿童学校是一个 NIH赞助的疫苗和治疗评估单位（VTEU）网络内的长期网站，以及 在疫苗临床试验中具有独特的优势，包括控制人类感染模型（CHIM）， 宋内志贺菌、诺如病毒、霍乱和流感疫苗的评价;免疫启动试验 新型RSV疫苗，以及系统疫苗学工具的应用，以阐明细胞/分子 导致年轻人和老年人对疫苗成功产生适应性免疫反应的途径 个体我们项目的研究人员领导了一项由U 01资助的大型孕妇队列研究， 研究婴儿对流感感染和疫苗接种的最早反应，以了解 免疫印记的原理VTP具有优秀的基础科学教师追求广泛的 与疫苗开发有关的各种项目，包括传染病发病机理领域， 新的免疫原设计，免疫发展和调节的基本方面，计算和 与疫苗有关的功能基因组学，生殖生物学和免疫学。VTP将提供 接受医学博士培训，哲学博士、和MD-PhD博士后研究人员，将促进他们的发展， 致力于疫苗相关研究的成功的独立研究者。该计划将支持4 该计划每年有10名受训人员，每名任期2年。22位专家导师， 科学导师和NIH资助的研究项目的记录将作为VTP导师， 教师。将向所有疫苗培训方案学员提供疫苗科学广度方面的正规教育， 疫苗学研讨会课程，涵盖疫苗学的临床到床边方面， 写作，以及与研究项目和重点（基础或翻译）相关的有针对性的课程 个别学员。我们的计划致力于招募来自不同背景，种族， 和种族。预期的结果是培养和发展职业培训方案的学员成为有创造力的、独立的 科学家们将组成未来的疫苗学队伍。