Vaccinology Training Program

这是T32培训计划的新申请，该计划将培训下一代疫苗领导者 科学。疫苗学培训计划(VTP)建立在疫苗开发的强大遗产基础上， 辛辛那提儿童医院和辛辛那提大学率先推出了包括脊髓灰质炎口服疫苗在内的 大卫·伯恩斯坦博士开发的世界领先轮状病毒疫苗 和Richard Ward，以及最近对多种COVID疫苗的评估。辛辛那提儿童医院是一家 NIH赞助的疫苗和治疗评估单位(VTEU)网络中的长期站点，以及 在疫苗临床试验中具有独特的优势，包括受控人类感染模型(CHIM) 宋内氏志贺氏菌、诺如病毒、霍乱和流感疫苗的评价；研究人员发起的试验 新的RSV疫苗，以及系统疫苗学工具的应用，以阐明细胞/分子 导致年轻人和老年人对疫苗的成功适应性免疫反应的途径 个人。我们项目中的研究人员领导了一项由U01资助的大型队列研究，研究对象是孕妇及其 研究婴儿对流感感染和疫苗的最早反应，以了解 免疫印迹原理。VTP以杰出的基础科学教师为特色，追求广泛的 与疫苗开发相关的各种项目，包括传染病发病机制领域， 新的免疫原设计，免疫发展和调节的基本方面，计算和 与疫苗、生殖生物学和免疫学相关的功能基因组学。VTP将提供 对医学博士、博士和医学博士博士后研究人员的培训，将促进他们发展成为 成功的独立调查人员致力于疫苗相关研究。该计划将支持4个 每年参加该计划的实习生，每人的任期为2年。22位跟踪能力强的专家导师 在科学导师和NIH资助的研究项目中的记录将作为VTP导师和 教职员工。将向所有VTP学员提供广泛的疫苗科学方面的正规教育，包括 疫苗学研讨会课程，涵盖从工作台到床边的疫苗学、正规教育和补助金 写作，以及与研究项目相关的有针对性的课程作业和重点(基础或翻译) 个别受训人员。我们的计划致力于招募来自不同背景、种族、 和种族。预期的结果是培养和发展VTP学员成为有创造力的、独立的 科学家们将组成未来的疫苗工作队伍。

This is a new application for a T32 training program that will train the next generation of leaders in vaccine science. The Vaccinology Training Program (VTP) builds on a strong legacy of vaccine development at Cincinnati Children’s Hospital and the University of Cincinnati that includes the oral polio vaccine pioneered by Albert Sabin, the development of one of the world’s leading rotavirus vaccines by Drs. David Bernstein and Richard Ward, and the more recent evaluation of multiple COVID vaccines. Cincinnati Children’s is a longstanding site within the NIH-sponsored Vaccine and Treatment Evaluation Unit (VTEU) network, and features unique strengths in vaccine clinical trials including controlled human infection models (CHIMs) for evaluation of vaccines against Shigella sonnei, norovirus, cholera, and influenza; investigator-initiated trials for novel RSV vaccines, and application of systems vaccinology tools to elucidate the cellular/molecular pathways that lead to successful adaptive immune responses to vaccines in both young and aged individuals. Investigators in our program lead a large U01-funded cohort study of pregnant women and their infants studying the earliest responses to influenza infection and vaccination in order to understand the principles of immunologic imprinting. The VTP features outstanding basic science faculty pursuing a wide variety of projects relevant to vaccine development, including the areas of infectious disease pathogenesis, novel immunogen design, basic aspects of immune development and regulation, computational and functional genomics related to vaccines, and reproductive biology and immunology. The VTP will provide training to M.D., Ph.D., and MD-PhD postdoctoral researchers that will facilitate their development into successful independent investigators devoted to vaccine-relevant research. The program will support 4 trainees in the program per year, each appointed to 2-year terms. 22 expert mentors with strong track records in scientific mentorship and NIH-funded research programs will serve as the VTP mentors and faculty. Formal education in the breadth of vaccine sciences will be provided to all VTP trainees, including a seminar course in vaccinology covering bench-to-bedside aspects of vaccinology, formal education in grant writing, and targeted coursework relevant to the research project and focus (basic or translational) of individual trainees. Our program is dedicated to recruitment of trainees from diverse backgrounds, races, and ethnicities. The intended outcome is to nurture and develop VTP trainees into creative, independent scientists who will form the vaccinology workforce of the future.