Peru Vanderbilt – PREvention through VacciNation Training (PREVENT) program

摘要 虽然疫苗接种是预防传染病的最有效工具，但在发达国家和 在发展中国家，实施有效的疫苗接种计划是具有挑战性的。这一发展， 引入和实施有效的疫苗接种取决于当地产生的证据的可用性， 特别是地方监管部门要求的数据。实现这一目标的一个基本要求是 有训练有素的当地研究人员，他们清楚地了解疫苗背后的过程 研发、疫苗引进和项目实施。对已取得成就的研究人员进行培训 接种疫苗对抗菌素耐药感染的影响，间接保护与生物学的相关性 疫苗接种计划带来的压力是公认的疫苗接种主题的例子，这些主题是 通常被忽视了。正确认识疫苗接种对未接种人群的影响 间接免疫或群体免疫是至关重要的，但这经常被误解。此外，人们越来越不信任 疫苗和疫苗接种计划需要由研究人员用适当的技术解决 技能。因此，全球对疫苗学培训和疫苗可预防研究的需求日益增长。 疾病涵盖从疫苗开发到现场实施和规划的整个过程 评估。为了满足这些需求，范德比尔特大学医学中心(VUMC)、 中立国调查(IIN)和赫雷迪亚大学(UPCH)联手 建立秘鲁-范德比尔特预防接种培训计划(预防)。的总目标是 预防就是要培养一支具备现代知识和专业技能的研究人员和教育工作者队伍 领导秘鲁的疫苗可预防疾病研究和培训，并鼓励美国的研究人员 在低收入和中等收入国家从事疫苗接种研究。防止构建在非常 与IIN和UPCH成功地建立了14年研究伙伴关系，并就范德比尔特疫苗培训和 评价股和药物流行病学司在可预防疫苗研究方面的专门知识 疾病、培训和指导。预防将支持10名中长期实习生(硕士、博士和 教员奖学金)。具体地说，预防的目标是1)培训一支研究人员和教育工作者(培训者)干部队伍 在秘鲁开展多学科疫苗可预防疾病研究并建设培训能力；2)培训 秘鲁疫苗可预防疾病研究的科学家和未来领导者；以及，3)确保和记录 预防的长期影响。正在进行的IIN/UPCH-Vanderbilt研究伙伴关系已被高度证明 多产且成功。以疫苗学和疫苗研究为重点的新培训计划 可预防的疾病和结构的增长以及增加赠款成功率的努力将推动 UPCH走向疫苗可预防疾病的新地平线并满足秘鲁对世界级疫苗的需求 接受过疫苗接种培训的劳动力。

SUMMARY While vaccination is the most efficient tool for the prevention of infectious diseases both in developed and developing countries, the implementation of effective vaccination programs is challenging. The development, introduction and implementation of effective vaccination depends on availability of locally generated evidence, especially data required by local regulatory authorities. An essential requirement to make this happen is to have well-trained local researchers who have a clear understanding of the process behind vaccine development, vaccine introduction and program implementation. Training of researchers on the achieved impact of vaccination on antimicrobial resistant infections, the relevance of indirect protection and the biological pressure induced by vaccination programs are examples of well-established vaccination topics that are commonly overlooked. A proper understanding of the effects of vaccination on unvaccinated groups through indirect or herd immunity is crucial, but this is frequently misinterpreted. Moreover, there is a growing distrust in vaccines and vaccination programs that needs to be addressed by researchers with appropriate technical skills. Thus, there is a growing global need for training in vaccinology and the study of vaccine-preventable diseases encompassing the entire process from vaccine development to field implementation and program evaluation. To address these needs, Vanderbilt University Medical Center (VUMC), the Instituto de Investigacion Nutricional (IIN) and the Universidad Peruana Cayetano Heredia (UPCH) are joining forces to build the Peru-Vanderbilt Prevention through Vaccination Training Program (PREVENT). The overall goal of PREVENT is to develop a cadre of researchers and educators equipped with modern knowledge and expertise to lead vaccine preventable diseases research and training in Peru and to encourage US-based researchers to engage in vaccination research in low- and middle-income country (LMICs). PREVENT builds on the very successful 14-year Research Partnership with the IIN and UPCH and on the Vanderbilt Vaccine Training and Evaluation Unit and the Division of Pharmacoepidemiology's expertise in the study of vaccine preventable diseases, training and mentoring. PREVENT will support 10 medium-long term trainees (Master's, PhD and faculty fellowships). Specifically, PREVENT aims to 1) Train a cadre of researchers and educators (trainers) to conduct multidisciplinary vaccine preventable diseases research and build training capacity in Peru; 2) Train scientists and future leaders in vaccine-preventable diseases research in Peru; and, 3) Ensure and document PREVENT's long-term impact. The ongoing IIN/UPCH-Vanderbilt Research Partnership has proven highly productive and successful. A new training program focusing on Vaccinology and the study of vaccine preventable diseases and the growth of structures and efforts to increase grant success will move IIN and UPCH toward a new horizon in vaccine preventable diseases and address Peru's need for a world-class workforce trained in vaccinology.