Training in Research on Vascular Inflammation and Injury

该计划旨在培训基础和翻译研究方面的博士后和博士后科学家，重点是 心脏、脑、肺、肾、肠道和胎盘的血管炎症和相关疾病或损伤。AS 所有的组织都通过血管和淋巴管连接在一起，循环中的炎症反应起着 在多器官功能障碍和包括高血压在内的病理的发生和发展中发挥核心作用， 动脉粥样硬化、心律失常、心肌梗塞、急性呼吸窘迫综合征、中风、先兆子痫、 神经退行性疾病、创伤性脑损伤和败血症。最近发现的血管炎是一种主要的 新冠肺炎患者的死亡和发病原因进一步强调了未来研究的必要性 破译分子/细胞机制并确定血管炎症的诊断/治疗靶点。 该计划的目标是提供全面的研究培训，重点是分子和细胞 炎症和相关器官损伤的基础，利用我们教员的国家公认的专业知识 在炎症研究和血管生物学方面。导师队伍由来自7个系的20名导师组成。 6个跨部门项目或研究中心，其中7个拥有医学博士学位，4个正在执业 医生；他们都得到了美国国立卫生研究院的资助，并在毕业前和毕业前都有丰富的指导经验 博士后水平。该集团已经在研究和培训方面建立了密切的合作关系， 对研究生的共同指导，在许多出版物和演讲中的联合作者， 以及在拨款申请方面的共同努力。靠近他们的实验室，以及集中化的管理 由项目主任主持的部门提供的支持，进一步使密切的导师-被辅导者 互动。学员将从大量基础科学博士生和研究生中挑选出来 项目，以及与心血管科学有关的14个住院医师/研究员项目。一个重要的 部分受训人员(高达27%)来自代表性不足的种族/民族群体或具有社会经济背景 弱势群体背景。该计划设计包括一套全面的培训模式，包括 由教学课程和工作坊组成的严格的课程，以建立知识和能力，以及 密集的研究项目，强调实践经验和批判性/创新性思维，以及个性化的 发展计划，使受训人员不仅具备工作场所的生存技能，而且具备远见和能力 领导独立研究。学员将沉浸在高度协作的环境中，由 致力于心脏研究所、神经科学研究所、全光谱核心的大量机构资源 服务，为教师导师提供过渡性资金，以及为学员提供学费减免和津贴补充。此外, 该计划为学员提供了几个独特的学习技术和实验方法的机会 这是其他地方不常见的，包括血液中的3/4D活体显微/分子成像 淋巴微血管学，以及利用完整的、有功能的人体器官进行的翻译研究。

This program is designed to train pre- and postdoctoral scientists in basic and translational research, focusing on vascular inflammation and associated disease or injury in the heart, brain, lung, kidney, gut, and placenta. As all tissues are connected via blood vessels and lymphatics, inflammatory responses in the circulation play a central role in the onset and progression of multiple organ dysfunction and pathologies, including hypertension, atherosclerosis, arrythmia, myocardium infarction, acute respiratory distress syndrome, stroke, preeclampsia, neurodegenerative disorder, traumatic brain injury, and sepsis. The recent discovery of vasculitis as a leading cause of mortality and morbidity in patients with COVID-19 further accentuates the need for future research to decipher molecular/cellular mechanisms and identify diagnostic/therapeutic targets for vascular inflammation. The goal of this program is to provide comprehensive training in research focusing on the molecular and cellular basis of inflammation and related organ injury, taking advantage of our faculty's nationally recognized expertise in inflammation research and vascular biology. The mentoring faculty consist of 20 mentors from 7 departments across 6 inter-departmental programs or research centers, 7 of whom hold MD/PhD degrees and 4 are practicing physicians; all have been funded by the NIH and have extensive experience in mentoring at both pre- and postdoctoral levels. The group has already established a close collaborative relationship in research and training, evidenced by co-mentorship for graduate students, co-authorship in numerous publications and presentations, and joint effort in grant applications. The proximity of their laboratories, along with the centralized administrative support provided by the department chaired by the program director, further enables close mentor-mentee interactions. Trainees will be selected from a large pool of PhD candidates and postgraduates in basic science programs, as well as 14 medical residency/fellowship programs related to cardiovascular sciences. A significant portion (up to 27%) of trainees come from underrepresented racial/ethnic groups or with socioeconomically disadvantaged backgrounds. The program design includes a comprehensive set of training modalities, featuring a rigorous curriculum composed of didactic courses and workshops to build knowledge and competency, an intensive research project emphasizing hands-on experience and critical/innovative thinking, and a personalized development plan to equip the trainees with not only workplace survival skills but also the vision and capability to lead independent research. Trainees will be immersed in a highly collaborative environment supported by substantial institutional resources committed to the Heart Institute, Neuroscience Institute, full-spectrum core services, bridge funding for faculty mentors, and tuition waiver and stipend supplement for trainees. In addition, the program offers several unique opportunities for trainees to learn techniques and experimental approaches that are not commonly available elsewhere, including 3/4D intravital microscopic/molecular imaging in the blood and lymph microvasculature, and translational studies using intact, functionally viable human organs.