Training in Research on Vascular Inflammation and Injury

该计划旨在培养基础和转化研究的博士前和博士后科学家，重点是 血管炎症和相关疾病或心脏、脑、肺、肾、肠道和胎盘损伤。作为 所有组织都通过血管和毛细血管连接，循环中的炎症反应起着重要作用。 在多器官功能障碍和病理学，包括高血压， 动脉粥样硬化、心律失常、心肌梗塞、急性呼吸窘迫综合征、中风、先兆子痫， 神经变性病症、创伤性脑损伤和败血症。最近发现血管炎是导致 COVID-19患者的死亡和发病原因进一步强调了未来研究的必要性， 破译分子/细胞机制并鉴定血管炎症的诊断/治疗靶点。 该计划的目标是提供全面的研究培训，重点是分子和细胞 炎症和相关器官损伤的基础上，利用我们的教师的国家认可的专业知识 炎症研究和血管生物学。指导教师由来自7个部门的20名导师组成 6个跨部门项目或研究中心，其中7人拥有MD/PhD学位，4人正在实践 医生;所有人都得到了NIH的资助，并在产前和产后指导方面拥有丰富的经验。 博士后水平。该小组已在研究和培训方面建立了密切的合作关系， 通过研究生的共同导师，在许多出版物和演讲中的共同作者， 并共同努力申请补助金。他们的实验室靠近，沿着中央行政区 由项目主任主持的部门提供的支持，进一步使密切的导师-学员 交互.学员将从基础科学的博士候选人和研究生中挑选 项目，以及14个与心血管科学相关的医疗住院医师/奖学金项目。显著 一部分（高达27%）的受训人员来自代表性不足的种族/族裔群体，或在社会经济上有困难的人。 弱势背景。该计划的设计包括一套全面的培训模式， 由教学课程和讲习班组成的严格课程，以建立知识和能力， 强化研究项目，强调实践经验和批判性/创新思维，以及个性化的 发展计划，让学员不但掌握工作场所的生存技能，还具备远见和能力 领导独立研究。学员将沉浸在一个高度协作的环境中， 大量的机构资源致力于心脏研究所，神经科学研究所，全谱核心 为教师导师提供过渡资金，为学员提供学费减免和津贴补贴。此外，本发明还提供了一种方法， 该计划为学员提供了几个独特的机会来学习技术和实验方法 其他地方不常见的，包括血液中的3/4D活体显微镜/分子成像 和淋巴微血管系统，以及使用完整的、功能上可行的人体器官的翻译研究。

This program is designed to train pre- and postdoctoral scientists in basic and translational research, focusing on vascular inflammation and associated disease or injury in the heart, brain, lung, kidney, gut, and placenta. As all tissues are connected via blood vessels and lymphatics, inflammatory responses in the circulation play a central role in the onset and progression of multiple organ dysfunction and pathologies, including hypertension, atherosclerosis, arrythmia, myocardium infarction, acute respiratory distress syndrome, stroke, preeclampsia, neurodegenerative disorder, traumatic brain injury, and sepsis. The recent discovery of vasculitis as a leading cause of mortality and morbidity in patients with COVID-19 further accentuates the need for future research to decipher molecular/cellular mechanisms and identify diagnostic/therapeutic targets for vascular inflammation. The goal of this program is to provide comprehensive training in research focusing on the molecular and cellular basis of inflammation and related organ injury, taking advantage of our faculty's nationally recognized expertise in inflammation research and vascular biology. The mentoring faculty consist of 20 mentors from 7 departments across 6 inter-departmental programs or research centers, 7 of whom hold MD/PhD degrees and 4 are practicing physicians; all have been funded by the NIH and have extensive experience in mentoring at both pre- and postdoctoral levels. The group has already established a close collaborative relationship in research and training, evidenced by co-mentorship for graduate students, co-authorship in numerous publications and presentations, and joint effort in grant applications. The proximity of their laboratories, along with the centralized administrative support provided by the department chaired by the program director, further enables close mentor-mentee interactions. Trainees will be selected from a large pool of PhD candidates and postgraduates in basic science programs, as well as 14 medical residency/fellowship programs related to cardiovascular sciences. A significant portion (up to 27%) of trainees come from underrepresented racial/ethnic groups or with socioeconomically disadvantaged backgrounds. The program design includes a comprehensive set of training modalities, featuring a rigorous curriculum composed of didactic courses and workshops to build knowledge and competency, an intensive research project emphasizing hands-on experience and critical/innovative thinking, and a personalized development plan to equip the trainees with not only workplace survival skills but also the vision and capability to lead independent research. Trainees will be immersed in a highly collaborative environment supported by substantial institutional resources committed to the Heart Institute, Neuroscience Institute, full-spectrum core services, bridge funding for faculty mentors, and tuition waiver and stipend supplement for trainees. In addition, the program offers several unique opportunities for trainees to learn techniques and experimental approaches that are not commonly available elsewhere, including 3/4D intravital microscopic/molecular imaging in the blood and lymph microvasculature, and translational studies using intact, functionally viable human organs.