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中文摘要
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项目总结: 临床前研究核心(PRC)将为使用临床前研究的研究人员提供集中的资源 彭宁顿生物医学研究中心疾病的新陈代谢基础中的模型。中华人民共和国将 支持动物研究的方方面面,包括实验设计、体内程序的执行、获取 以及使用最先进的设备进行动物表型鉴定、数据分析和解释的培训, 使用转基因小鼠品系,并在动物健康和监管领域提供普遍支持 合规性。中华人民共和国的首要目标是统一和扩展目前支持的现有资源 将临床前研究转化为一个有凝聚力的团队,有效地指导、培训和支持Cobre研究人员。 考虑到Cobre的每个研究项目都利用了临床前模型、指导、技术 驻留在中国境内的支持和设备应能显著提高生产力和创新 每个研究项目。
英文摘要
Project Summary: The Preclinical Research Core (PRC) will provide a centralized resource for investigators utilizing preclinical models within Pennington Biomedical Research Center’s Metabolic Basis of Disease COBRE. The PRC will support all aspects of animal research, including experimental design, execution of in vivo procedures, access and training in the use of state-of-the-art equipment for animal phenotyping, data analysis and interpretation, use of genetically-modified mouse lines, and general support in areas of animal health and regulatory compliance. The overarching goal of the PRC is to unify and extend existing resources that currently support preclinical research into a cohesive team that effectively mentors, trains and supports COBRE investigators. Considering that each of the COBRE research projects utilizes preclinical models, the mentoring, technical support and equipment housed within the PRC should substantially enhance the productivity and innovation of each research project.
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Preclinical
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
Neural circuits coordinating protein intake: Role of FGF21
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
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