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Neural circuits coordinating protein intake: Role of FGF21

协调蛋白质摄入的神经回路：FGF21 的作用

基本信息

批准号：
10449404
负责人：
Christopher D Morrison
金额：
$ 33.3万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10449404
关键词：
Animals Area Automobile Driving Behavioral Behavioral Mechanisms Biology Brain Complex Consumption Data Diet Habits Dopamine Eating Energy Intake Environment Exhibits FGF21 gene Family member Feeding behaviors Fibroblast Growth Factor Food Food Intake Regulation Genetic Models Health Homeostasis Hormones Individual Learning Liver Macronutrients Nutrition Mammals Mediating Metabolic Metabolism Methodology Motivation Mus Neurobiology Neurons Nutritional Pharmacology Phenotype Physiological Population Protein-Restricted Diet Proteins Regulation Role Signal Transduction Signaling Protein Site System Taste Perception Testing Work base dietary dietary control experimental study feeding insight mind control molecular phenotype motivated behavior mouse genetics neural circuit neurobehavioral neurobiological mechanism neuromechanism novel protein intake receptor relating to nervous system response virtual

项目摘要

Project Summary Survival is contingent upon physiologically and behaviorally adapting to a changing nutritional environment, and in mammals this homeostasis is largely mediated by nutritional hormones acting in the brain. Recent decades have seen substantial progress in our understanding of the neural mechanisms mediating energy intake and total food intake, but how animals sense individual macronutrients and self-select between them remains poorly defined. Our lab has recently discovered that the liver-derived hormone FGF21 acts in the brain as a signal of protein status. While normal mice adaptively ‘sense’ protein restriction and alter food intake in order to specifically seek and consume protein, this response is lost in mice lacking FGF21 or brain FGF21 signaling. The project will define the brain areas and neural phenotypes mediating FGF21-dependent changes in feeding behavior, and in doing so will provide the first insight into the neurobiology governing macronutrient choice. Despite the importance of dietary composition and food choice to health, and despite persistent dietary advice to change eating habits, we know almost nothing about how the brain controls dietary macronutrient choice. Thus the work proposed in this application will substantially impact the field by rigorously probing the novel mechanisms controlling feeding behavior.

项目概要生存取决于生理和行为上对不断变化的营养环境的适应，在哺乳动物中，这种体内平衡很大程度上是由大脑中作用的营养激素介导的。最近的几十年来，我们对调节能量的神经机制的理解取得了实质性进展摄入量和总食物摄入量，但动物如何感知单个常量营养素并在它们之间进行自我选择仍然不明确。我们实验室最近发现肝源性激素 FGF21 作用于大脑作为蛋白质状态的信号。而正常小鼠会适应性地“感知”蛋白质限制并改变食物摄入量为了专门寻找和消耗蛋白质，这种反应在缺乏 FGF21 或大脑 FGF21 的小鼠中消失发信号。该项目将定义介导 FGF21 依赖性变化的大脑区域和神经表型喂养行为，这样做将首次深入了解控制常量营养素的神经生物学选择。尽管膳食成分和食物选择对健康很重要，尽管坚持不懈的饮食改变饮食习惯的建议，我们对大脑如何控制饮食大量营养素几乎一无所知选择。因此，本申请中提出的工作将通过严格探索该领域对该领域产生重大影响。控制进食行为的新机制。