LOUISIANA COBRE: P4: MECHANISMS OF AGING-INDUCED LEPTIN RESISTANCE AND OBESITY
LOUISIANA COBRE: P4: MECHANISMS OF AGING-INDUCED LEPTIN RESISTANCE AND OBESITY
批准号:
8167952
负责人:
Christopher D Morrison
金额:
$20.58万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-07-01 至 2011-06-30
关键词:
AgeAgingAnimalsAntioxidantsAreaBehaviorBrainComputer Retrieval of Information on Scientific Projects DatabaseDietFatty acid glycerol estersFundingGrantHippocampus (Brain)Hypothalamic structureInstitutionLeptinLeptin resistanceLouisianaMetabolismNeuronsObesityOxidative StressResearchResearch PersonnelResourcesSignal TransductionSourceTestingUnited States National Institutes of Healthenzyme activity
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
A. Specific Aims
Specific Aim 1: Test the hypothesis that aging enhances the negative effects of high fat diet (HFD) on brain leptin signaling, metabolism and behavior.
Specific Aim 2: Test the hypothesis that aging will impair the ability of the animal to reduce body adiposity and recover normal brain leptin signaling following cessation of a HFD.
Specific Aim 3: Test the hypothesis that leptin protects against oxidative stress in hypothalamic and hippocampal neurons by enhancing antioxidant enzyme activity via NRF2 signaling.
Specific Aim 4: Determine the functional interaction between leptin signaling and oxidative stress within areas of the hippocampus and hypothalamus.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Preclinical
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批准号:10569511
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项目类别:
-
资助金额:$40.49万
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财政年份:2020
-
负责人:Christopher D Morrison
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依托单位:
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
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批准号:10359751
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项目类别:
-
资助金额:$37.0万
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财政年份:2020
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负责人:Christopher D Morrison
-
依托单位:
Neural circuits coordinating protein intake: Role of FGF21
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批准号:10263297
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项目类别:
-
资助金额:$33.3万
-
财政年份:2020
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负责人:Christopher D Morrison
-
依托单位:
Preclinical
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批准号:10333352
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项目类别:
-
资助金额:$31.29万
-
财政年份:2020
-
负责人:Christopher D Morrison
-
依托单位:
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
-
批准号:10578837
-
项目类别:
-
资助金额:$37.0万
-
财政年份:2020
-
负责人:Christopher D Morrison
-
依托单位:
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
-
批准号:10161777
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项目类别:
-
资助金额:$37.0万
-
财政年份:2020
-
负责人:Christopher D Morrison
-
依托单位:
Neural circuits coordinating protein intake: Role of FGF21
-
批准号:10662472
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项目类别:
-
资助金额:$33.3万
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财政年份:2020
-
负责人:Christopher D Morrison
-
依托单位:
Neural circuits coordinating protein intake: Role of FGF21
-
批准号:10449404
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项目类别:
-
资助金额:$33.3万
-
财政年份:2020
-
负责人:Christopher D Morrison
-
依托单位:
FGF21-dependent mechanisms driving changes in energy expenditure during dietary protein restriction
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批准号:9973291
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项目类别:
-
资助金额:$37.0万
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财政年份:2020
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负责人:Christopher D Morrison
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依托单位:
Sable Systems Promethion for Mouse Metabolic Analysis
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批准号:9281302
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项目类别:
-
资助金额:$62.58万
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财政年份:2017
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负责人:Christopher D Morrison
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依托单位:
FGF21 is an endocrine signal of protein restriction
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批准号:9388340
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项目类别:
-
资助金额:$33.3万
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财政年份:2015
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负责人:Christopher D Morrison
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依托单位:
FGF21 is an endocrine signal of protein restriction
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批准号:9274081
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项目类别:
-
资助金额:$3.45万
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财政年份:2015
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负责人:Christopher D Morrison
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依托单位:
Neural regulation of protein ingestion
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批准号:7785633
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项目类别:
-
资助金额:$33.3万
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财政年份:2010
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负责人:Christopher D Morrison
-
依托单位:
Neural regulation of protein ingestion
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批准号:8049740
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项目类别:
-
资助金额:$28.52万
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财政年份:2010
-
负责人:Christopher D Morrison
-
依托单位:
Neural regulation of protein ingestion
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批准号:8664366
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项目类别:
-
资助金额:$27.49万
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财政年份:2010
-
负责人:Christopher D Morrison
-
依托单位:
Neural regulation of protein ingestion
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批准号:8468686
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项目类别:
-
资助金额:$26.54万
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财政年份:2010
-
负责人:Christopher D Morrison
-
依托单位:
Neural regulation of protein ingestion
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批准号:8280397
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项目类别:
-
资助金额:$27.52万
-
财政年份:2010
-
负责人:Christopher D Morrison
-
依托单位:
LOUISIANA COBRE: P4: MECHANISMS OF AGING-INDUCED LEPTIN RESISTANCE AND OBESITY
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批准号:7959987
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项目类别:
-
资助金额:$23.41万
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财政年份:2009
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负责人:Christopher D Morrison
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依托单位:
LOUISIANA COBRE: P4: MECHANISMS OF AGING-INDUCED LEPTIN RESISTANCE AND OBESITY
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批准号:7720514
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项目类别:
-
资助金额:$21.13万
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财政年份:2008
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负责人:Christopher D Morrison
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依托单位:
LOUISIANA COBRE: P4: MECHANISMS OF AGING-INDUCED LEPTIN RESISTANCE AND OBESITY
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批准号:7610784
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项目类别:
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资助金额:$20.96万
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财政年份:2007
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负责人:Christopher D Morrison
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依托单位:
海外基金