Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System

内华达心血管系统分子和细胞信号转导生物医学卓越研究中心

• 批准号: 10332744
• 负责人: Scott Earley
• 金额: $ 215.85万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10332744
• 关键词: Aging; Animal Model; Area; Back; Basic Science; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cell Surface Receptors; Cell physiology; Centers of Research Excellence; Collaborations; Communities; Coupling; Development; Disease; Endothelial Cells; Environment; Epigenetic Process; Foundations; Funding; Genotype; Goals; Grant; Health; Healthcare Systems; Human; Image; Individual; Infrastructure; Institutes; Interdisciplinary Study; International; Ion Channel; Journals; Lead; Leadership; Link; Medical; Mentors; Methodology; Mission; Molecular; Neurons; Nevada; Pharmacology; Phase; Phenotype; Population; Principal Investigator; Program Research Project Grants; Publications; Publishing; Records; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Scientist; Signal Transduction; Signal Transduction Pathway; Smooth Muscle Myocytes; Source; Time; Transgenic Animals; United States National Institutes of Health; Universities; Work; career; collaborative environment; common treatment; disability; improved; innovation; insight; interest; medical schools; member; multidisciplinary; novel; professor; programs; temporal measurement; therapeutic development

Project Summary The goal of this new Phase I Center of Biomedical Research Excellence (COBRE) proposal is to establish and develop a new interdisciplinary research Center within the University of Nevada, Reno (UNR), and the UNR School of Medicine (UNR Med) that is focused on fundamental molecular and cellular signal transduction mechanisms within the cardiovascular system. This COBRE will be unique, as there are no existing centers or institutes with a focus on basic cardiovascular research within the State of Nevada. The unifying scientific theme of the new COBRE is the discovery and characterization of novel molecular and cellular signaling mechanisms that regulate the cardiovascular system in health and disease. This research mission is significant, because cardiovascular diseases remain the leading causes of death and disability in the US and much of the world. We expect that COBRE-sponsored research programs will develop deep insight into the basic molecular and cellular signaling mechanisms that regulate cardiovascular function, thereby accelerating the rate of discovery of new treatments for common cardiovascular diseases and ultimately improving human health. The primary function of Phase I is to provide mentoring and support for COBRE’s Project Leaders, a group of four promising early-stage investigators, with the goal of developing them into fully established research scientists funded by independent Research Program Grants (RPGs), such as an NIH R01 or equivalent. The COBRE will also improve the research infrastructure at UNR and UNR Med by establishing and developing two new research cores—the Transgenic Animal Genotyping and Phenotyping Core (Core B) and the High Spatial and Temporal Resolution Imaging Core (Core C)—to serve the needs of the Project Leaders and the wider research community. Phase I of the COBRE will lay the groundwork for long-term sustainability of the Center by increasing the number of RPG-supported investigators within the thematic focus at UNR and UNR Med, and by promoting collaborations among these investigators to stimulate the development of new multi-PI R01s and Program Project Grants. Dr. Scott Earley, Professor of Pharmacology at UNR Med, is the Principal Investigator and COBRE Director. Dr. Earley is an accomplished investigator with an established track record of NIH R01 funding and publication in high-quality journals. Additional scientific leadership will be provided by a group of four outstanding established investigators with common interests in ion channels, localized Ca2+ signaling, intracellular signal transduction pathways, transgenic animal models, endothelial cell function, epigenetics, novel cell surface receptors, neuronal cardiovascular control, localized signaling domains, and excitation/contraction coupling in cardiomyocytes and smooth muscle cells. Successful completion of the objectives of Phase I will establish the Nevada COBRE in Molecular and Cellular Signal Transduction in the Cardiovascular System as a sustainable multidisciplinary research Center with a critical mass of investigators working within this thematic focus.

项目摘要 这个新的生物医学研究卓越中心（COBRE）提案的第一阶段目标是建立和 在内华达州里诺大学（UNR）和UNR内建立一个新的跨学科研究中心 医学院（UNR Med），专注于基础分子和细胞信号转导 心血管系统内的机制。这个COBRE将是独一无二的，因为没有现有的中心， 在内华达州内的基础心血管研究机构。统一的科学主题 新COBRE的一个重要特点是发现和表征了新的分子和细胞信号传导机制 在健康和疾病中调节心血管系统。这项研究使命意义重大，因为 心血管疾病仍然是美国和世界许多地方死亡和残疾的主要原因。我们 预计COBRE-S资助的研究计划将深入了解基本的分子和细胞 调节心血管功能的信号机制，从而加快发现新的 治疗常见的心血管疾病，并最终改善人类健康。的主要功能 第一阶段是为COBRE的项目负责人提供指导和支持，该项目负责人由四名有前途的早期项目负责人组成 研究人员，其目标是将他们发展成为由独立研究机构资助的完全成熟的研究科学家。 研究计划赠款（RPG），如NIH R 01或同等学历。COBRE还将改善 通过建立和发展两个新的研究核心， 转基因动物基因分型和表型核心（Core B）及其高时空分辨率 成像核心（核心C）-满足项目负责人和更广泛的研究社区的需求。一期 COBRE将通过增加 在UNR和UNR Med的专题重点范围内，通过促进合作， 在这些研究者中，鼓励开发新的多PI R 01和计划项目赠款。博士 UNR Med药理学教授Scott厄利是主要研究者和COBRE主任。博士 厄利是一位有成就的研究者，在NIH R 01的资助和出版方面有着良好的记录， 高质量期刊。由四位杰出的知名人士组成的小组将提供额外的科学领导 在离子通道、局部Ca 2+信号传导、细胞内信号转导方面有共同兴趣的研究者 途径，转基因动物模型，内皮细胞功能，表观遗传学，新型细胞表面受体，神经元 心血管控制，局部信号传导结构域和心肌细胞中的兴奋/收缩偶联， 平滑肌细胞成功完成第一阶段的目标将建立内华达州COBRE， 心血管系统中的分子和细胞信号转导作为一个可持续的多学科 该研究中心拥有大量在这一主题重点领域工作的调查人员。