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Project 3A: CWD Prion Shedding and Environmental Contamination: Role in Transmission and Zoonotic

项目 3A：CWD 朊病毒脱落和环境污染：在传播和人畜共患病中的作用

基本信息

批准号：
10332509
负责人：
Candace K. Mathiason
金额：
$ 42.94万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-15 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10332509
关键词：
American Animals Area Attention Binding Biological Assay Body Fluids Chronic Wasting Disease Deer Detection Endemic Diseases Environment Environmental Impact Environmental Pollution Environmental Risk Factor Evolution Gene Targeting Generations Genotype Geography Health Human In Vitro Infection Integration Host Factors Laboratories Lesion Livestock Lymphoid Tissue Methodology Methods Molecular Conformation Mus Pathogenesis Peptide Hydrolases PrP PrPSc Proteins Prion Diseases Prions Property Recombinants Resistance Risk Role Scandinavia Scandinavian Soil Surface Tail Testing Time Tissues Transgenic Organisms Variant Weather Western Blotting Work Zoonoses animal resource brain tissue cervid conformer contagion detection method disease transmission disorder risk in vivo particle prototype relating to nervous system transmission process zoonotic spillover

项目摘要

Chronic wasting disease (CWD) is an emergent, highly transmissible, geographically expanding, prion disease of both wild and captive cervids. CWD is unique among prion diseases in its facile contagion and environmental persistence. Its expanding geographical range, combined with the increasing transport of animals and animal products, portend its continued expansion and diversification. The zoonotic potential of CWD remains poorly understood. CWD endemic areas interface cervids with livestock species and humans, posing obvious zoonotic risks that over time will increase. While it is known that strains of CWD exist, nothing is known about the zoonotic potential of these strains. Work from our applicant group has shown that CWDinfected cervids continually shed prions into the environment and that previously unrecognized environmental factors can influence the emergence of a dominant strain from a mixture. The ability to recognize the zoonotic potential of CWD strains is central to mitigating CWD transmission risk. The central hypothesis for work described here is that CWD strains evolve continuously due to a combination of both host and environmental factors. We will test this hypothesis by: i) determining the evolution and zoonotic impact of CWD strains in the native cervid species; ii) leveraging our unique animal resources, expertise, and in vivo & in vitro methodologies to assess environmental factors that alter CWD strain selection and evolution and iii) evaluate zoonotic potential of CWD strains by a complementary combination of in vitro amplification assays and animal transmission studies. The results will provide new information about this emergent transmissible prion disease and the risk it poses to humans and other species.

慢性消耗性疾病（CWD）是一种新兴的、高度传播的、地理扩展的朊病毒