Comparative Pathology Shared Resource
比较病理学共享资源
基本信息
- 批准号:10333240
- 负责人:
- 金额:$ 10.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-06-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Animal ModelAnimalsApplications GrantsAutopsyBloodCancer CenterCancer Center Support GrantClinical ChemistryComparative PathologyConsultDataDoctor of PhilosophyEnsureEvaluationFeedbackFormalinFreezingFundingGrantHematologyHistologicHistologyHistopathologyImage AnalysisImmunohistochemistryLabelLaboratoriesLaboratory AnimalsMalignant NeoplasmsManuscriptsMeasurementMicroscopicMissionPathologicPathologistPathologyPhenotypePreparationProcessProteinsProtocols documentationPublicationsResearchResearch DesignResearch PersonnelResearch Project GrantsResolutionResource SharingResourcesSpecimenTechniquesTestingTissuesTransgenic AnimalsVeterinary Pathologyanimal tissuebonecomparativedigital imagingexperienceimpressioninterestmeetingsmembermorphometryoperation
项目摘要
Comparative Pathology Shared Resource Summary
The mission of the Comparative Pathology Shared Resource (CPSR) is to provide comprehensive pathology
support for Masonic Cancer Center (MCC) members who use laboratory animals in their research. The CPSR
is a critical resource for projects using animal tissues and is essential for publications involving pathological
changes in tissues. The CPSR operation has been led by M. Gerard O'Sullivan, MVB, PhD, since 2009 and is
supported by Technical Coordinator Katalin Kovacs, PhD; histotechnologist Paula Overn, HT, QIHC; and
postdoctoral research pathologist, Flaviu Tabaran DVM, PhD. Dr. O'Sullivan has more than 25 years of
experience in comparative and experimental veterinary pathology. The laboratory prepares appropriately
processed fixed or frozen tissues for histology and immunohistochemistry (IHC). Particular strengths of the
laboratory are in doing non-routine, challenging, or tedious histological preparations; performing IHC
preparations on multiple markers; developing new IHC protocols for markers of interest; and performing IHC on
bone. Board-certified veterinary pathologists provide expert gross and histopathologic analysis, generate high-
resolution digital images of specimens, and provide intellectual input on study design and manuscript
preparation for research projects and grant applications. The CPSR also has considerable experience in
developing new protocols and techniques and has developed 121 new IHC markers since 2012. In addition,
the CSPR has developed double-labeling techniques to simultaneously detect several combinations of
proteins. Requests for quantification of marker expression and histomorphometric evaluations have increased,
and CSPR has developed expertise to accommodate these requests. Weekly staff meetings and annual
feedback from CPSR users ensure that the resource is able to meet the needs of MCC members.
比较病理学共享资源摘要
比较病理学共享资源(CPSR)的使命是提供全面的病理学
支持共济会癌症中心(MCC)成员谁使用实验室动物在他们的研究。CPSR
是使用动物组织的项目的关键资源,对于涉及病理学的出版物是必不可少的。
组织的变化。CPSR行动由M. Gerard O 'Sullivan,MVB,博士,自2009年起,是
由技术协调员Katalin Kovacs博士、组织技术专家Paula Overn、HT、QIHC提供支持;
博士后研究病理学家,Flaviu Tabaran DVM,PhD。奥沙利文博士有超过25年的
具有比较和实验兽医病理学经验。实验室做好准备
经处理的固定或冷冻组织用于组织学和免疫组织化学(IHC)。特别优势的
实验室正在进行非常规的、具有挑战性的或繁琐的组织学制备;进行IHC
针对多种标记物的免疫组化制备;针对感兴趣的标记物开发新的免疫组化方案;以及
骨头委员会认证的兽医病理学家提供专家的大体和组织病理学分析,产生高-
标本的高分辨率数字图像,并为研究设计和手稿提供智力输入
准备研究项目和赠款申请。CPSR在以下方面也有相当丰富的经验:
自2012年以来,该公司开发了121种新的IHC标记物。此外,本发明还提供了一种方法,
CSPR已经开发了双标记技术,以同时检测以下几种组合:
proteins.对标记物表达和组织形态学评价的定量要求有所增加,
CSPR已经开发了专门知识来满足这些要求。每周工作人员会议和
CPSR用户的反馈确保资源能够满足MCC成员的需求。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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M. Gerard O'Sullivan其他文献
<strong>Examination of a blood-brain barrier targeting β-galactosidase-monoclonal antibody fusion protein in a murine model of GM1-gangliosidosis</strong>
- DOI:
10.1016/j.ymgme.2020.12.210 - 发表时间:
2021-02-01 - 期刊:
- 影响因子:
- 作者:
Michael Przybilla;Christine Stewart;Timothy Carlson;Li Ou;Brenda Koniar;Rohini Sidhu;Pamela Kell;Xuntian Jiang;Jeanine R. Jarnes;M. Gerard O'Sullivan;Chester B. Whitley - 通讯作者:
Chester B. Whitley
M. Gerard O'Sullivan的其他文献
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{{ truncateString('M. Gerard O'Sullivan', 18)}}的其他基金
PATHOGENESIS AND THERAPY OF B19-INDUCED HYDROPS FETALIS
B19 引起的胎儿水肿的发病机制和治疗
- 批准号:
2870343 - 财政年份:1997
- 资助金额:
$ 10.31万 - 项目类别:
PATHOGENESIS AND THERAPY OF B19-INDUCED HYDROPS FETALIS
B19 引起的胎儿水肿的发病机制和治疗
- 批准号:
2025934 - 财政年份:1997
- 资助金额:
$ 10.31万 - 项目类别:
PATHOGENESIS AND THERAPY OF B19-INDUCED HYDROPS FETALIS
B19 引起的胎儿水肿的发病机制和治疗
- 批准号:
2889284 - 财政年份:1997
- 资助金额:
$ 10.31万 - 项目类别:
MODEL DEVELOPMENT FOR B19 PARVOVIRUS FETAL INFECTION
B19 细小病毒胎儿感染的模型开发
- 批准号:
2899227 - 财政年份:1993
- 资助金额:
$ 10.31万 - 项目类别:
MODEL DEVELOPMENT FOR B19 PARVOVIRUS FETAL INFECTION
B19 细小病毒胎儿感染的模型开发
- 批准号:
2849694 - 财政年份:1993
- 资助金额:
$ 10.31万 - 项目类别:
MODEL DEVELOPMENT FOR B19 PARVOVIRUS FETAL INFECTION
B19 细小病毒胎儿感染的模型开发
- 批准号:
6031039 - 财政年份:1993
- 资助金额:
$ 10.31万 - 项目类别:
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