Tissue Core

组织核心

• 批准号: 10333182
• 负责人: Conor C Lynch
• 金额: $ 16.22万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-18 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333182
• 关键词: Accreditation; Active Sites; Address; Affect; American; Animal Model; Biological; Biological Assay; Blood; Blood specimen; Cancer Center; Cancer Center Support Grant; Catchment Area; Cells; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Collection; Communication; Consult; Custom; Data; Development; Dissociation; Documentation; Dysmyelopoietic Syndromes; Ensure; Ethics; Foundations; Fractionation; Freezing; Funding; Future; Generations; Genomics; Goals; Grant; Growth; Guidelines; Health Service Area; Histology; Human; Immunohistochemistry; In Situ; In Situ Hybridization; Individual; Laboratories; Liquid substance; Manuscripts; Minority Groups; Molecular; Molecular Analysis; National Heart, Lung, and Blood Institute; Natural History; Nucleic Acids; Operative Surgical Procedures; Outcome; Pathologist; Patients; Peer Review; Policies; Population; Procedures; Process; Proteomics; Protocols documentation; Publications; Recommendation; Reproducibility; Research; Research Design; Resource Sharing; Resources; Review Committee; Science; Series; Services; Specimen; Specimen Handling; Standardization; Targeted Research; Testing; Time; Tissue Banks; Tissue Microarray; Tissues; Training and Education; Translational Research; United States National Institutes of Health; Update; base; biobank; biological specimen archives; cancer care; clinical application; college; design; epigenomics; exosome; improved; laboratory experience; liquid biopsy; member; metabolomics; novel; patient population; peripheral blood; programs; quality assurance; sample collection; stool sample; translational study; tumor

PROJECT SUMMARY TISSUE CORE The Tissue Core (TC) serves as the central biorepository for Moffitt Cancer Center (Moffitt). Opened in 1992, the overall goal of TC is to collect, process, store, and release high-quality, well-annotated biospecimens in support of basic, clinical, population, quantitative and translational research. TC provides a wide variety of services including fresh frozen tissue collection, histology, immunohistochemistry, nucleic acid extraction, generation of tissue microarrays, and archived biospecimen release. Further, TC consults on and implements project-specific SOPs, including study design and collection strategies to optimize specimen handling. TC offers 75 distinct services that meet or exceed NCI best practice recommendations and CAP Biorepository Accreditation standards, which ensures rigor and reproducibility in sample collection and processing that is validated through standardization, documentation, and quality management. TC activities towards its goals are organized into three Specific Aims: Aim 1: To serve as the centralized Moffitt biobanking resource for the collection, processing, and storage of biospecimens. Aim 2: To facilitate and ensure access to high-quality biospecimens and state-of-the-science services through implementation of biorepository best practices. Aim 3: To enrich Member research through streamlined utilization, biospecimen education and training that ensures high-quality outcomes. Over the previous funding cycle, TC services continued to improve efficiency, communication, and turn-around times and the TC addressed the evolving complexity of specimen collection to support novel projects. This yielded three new service sections: Biospecimen Processing Services, TC Total Cancer Care Section to support Moffitt’s institutionally funded biobanking protocol, and TC Clinical Trial Biospecimen Services, which provides dedicated support for clinical trials. Further, TC collaborates as an active site for NIH consortium projects such as the Clinical Proteomic Tumor Analysis Consortium that provides biospecimen collection, processing, dissemination and data annotation via Moffitt’s Total Cancer Care institutional biobanking protocol. TC also serves as the Central Lab and Biorepository for NHLBI’s National Myelodysplastic Syndrome Natural History Study. Over the last five years, TC contributed to 188 publications (37 high impact) and 154 grants. In FY20 alone, TC supported 120 Members (69% peer review funded) in all five Programs (CBE 18 %, CE 18 %, MM 31 %, HOB 5%, IO 28%). Collectively, TC supported 350 protocols during FY20. Of those protocols, 219 were clinical trials, increasing from 93 in FY2019 and 64 in FY2018.

项目总结 组织芯 组织核心(TC)是莫菲特癌症中心(Moffitt)的中心生物储存库。1992年开业， TC的总体目标是收集、处理、存储和释放高质量的、注释良好的生物标本 支持基础研究、临床研究、人口研究、定量研究和转化研究。TC提供了广泛的 服务包括新鲜冰冻组织收集、组织学、免疫组织化学、核酸提取、 组织微阵列的生成和生物样品的归档释放。此外，TC还就以下事项进行咨询和实施 针对具体项目的标准操作规程，包括优化标本处理的研究设计和收集策略。TC优惠 符合或超过NCI最佳实践建议和CAP生物存储库的75项不同服务 认证标准，确保样本收集和处理的严密性和重复性，即 通过标准化、文档和质量管理进行验证。为实现其目标开展的技术合作活动包括 组织成三个具体目标： 目标1：作为集中的Moffitt生物库资源，收集、处理和存储 生物群落。 目标2：通过以下方式便利和确保获得高质量的生物检疫和最新科学服务 实施生物信息库最佳做法。 目标3：通过简化利用、生物科学教育和培训来丰富成员研究 确保高质量的成果。 在前一个资金周期中，TC服务继续提高效率、沟通和周转 《泰晤士报》和TC解决了标本收集的日益复杂的问题，以支持新的项目。这 产生了三个新的服务部门：生物制品加工服务、TC全面癌症护理科以支持 Moffitt的机构资助的生物库协议和TC临床试验Biospecimen服务，该服务提供 为临床试验提供专门支持。此外，TC作为NIH财团项目的积极站点进行合作 作为临床蛋白质组肿瘤分析联盟，提供生物样品收集、处理、 通过莫菲特的全面癌症护理机构生物库协议进行传播和数据注释。TC也 作为NHLBI全国骨髓增生异常综合征自然病史的中心实验室和生物库 学习。在过去五年中，技术合作委员会为188份出版物(37份高影响力)和154份赠款作出了贡献。在2020财年 仅在所有五个项目中，TC就支持了120名成员(69%由同行评审资助)(CBE 18%，CE 18%，MM 31 %，HOB 5%，IO 28%)。在2020财年期间，TC总共支持350个协议。在这些协议中，有219项是 临床试验，2019财年为93项，2018财年为。