Tissue Core

组织核心

• 批准号: 10558788
• 负责人: Conor C Lynch
• 金额: --
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-18 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558788
• 关键词: Accreditation; Active Sites; Address; Advisory Committees; Affect; American; Biological; Biological Assay; Biological Specimen Banks; Blood; Blood specimen; Cancer Center; Cancer Center Support Grant; Catchment Area; Cells; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Collection; Communication; Consult; Custom; Data; Dedications; Development; Dissociation; Documentation; Dysmyelopoietic Syndromes; Ensure; Ethics; Fractionation; Freezing; Funding; Future; Generations; Genomics; Goals; Grant; Growth; Guidelines; Health Service Area; Histology; Human; Immunohistochemistry; In Situ; In Situ Hybridization; Individual; Institution; Laboratories; Liquid substance; Manuscripts; Minority Groups; Molecular; Molecular Analysis; National Heart, Lung, and Blood Institute; Natural History; Nucleic Acids; Operative Surgical Procedures; Organizational Objectives; Outcome; Pathologist; Patients; Peer Review; Policies; Population; Procedures; Process; Proteomics; Protocols documentation; Publications; Recommendation; Reproducibility; Research; Research Design; Resource Sharing; Resources; Review Committee; Science; Series; Services; Specimen; Specimen Handling; Standardization; Targeted Research; Testing; Tissue Banks; Tissue Microarray; Tissues; Training and Education; Translational Research; United States National Institutes of Health; Update; biobank; biological specimen archives; cancer care; clinical application; college; design; epigenomics; exosome; improved; laboratory experience; liquid biopsy; member; metabolomics; model organism; novel; patient population; peripheral blood; programs; quality assurance; sample collection; stool sample; translational study; tumor

PROJECT SUMMARY TISSUE CORE The Tissue Core (TC) serves as the central biorepository for Moffitt Cancer Center (Moffitt). Opened in 1992, the overall goal of TC is to collect, process, store, and release high-quality, well-annotated biospecimens in support of basic, clinical, population, quantitative and translational research. TC provides a wide variety of services including fresh frozen tissue collection, histology, immunohistochemistry, nucleic acid extraction, generation of tissue microarrays, and archived biospecimen release. Further, TC consults on and implements project-specific SOPs, including study design and collection strategies to optimize specimen handling. TC offers 75 distinct services that meet or exceed NCI best practice recommendations and CAP Biorepository Accreditation standards, which ensures rigor and reproducibility in sample collection and processing that is validated through standardization, documentation, and quality management. TC activities towards its goals are organized into three Specific Aims: Aim 1: To serve as the centralized Moffitt biobanking resource for the collection, processing, and storage of biospecimens. Aim 2: To facilitate and ensure access to high-quality biospecimens and state-of-the-science services through implementation of biorepository best practices. Aim 3: To enrich Member research through streamlined utilization, biospecimen education and training that ensures high-quality outcomes. Over the previous funding cycle, TC services continued to improve efficiency, communication, and turn-around times and the TC addressed the evolving complexity of specimen collection to support novel projects. This yielded three new service sections: Biospecimen Processing Services, TC Total Cancer Care Section to support Moffitt’s institutionally funded biobanking protocol, and TC Clinical Trial Biospecimen Services, which provides dedicated support for clinical trials. Further, TC collaborates as an active site for NIH consortium projects such as the Clinical Proteomic Tumor Analysis Consortium that provides biospecimen collection, processing, dissemination and data annotation via Moffitt’s Total Cancer Care institutional biobanking protocol. TC also serves as the Central Lab and Biorepository for NHLBI’s National Myelodysplastic Syndrome Natural History Study. Over the last five years, TC contributed to 188 publications (37 high impact) and 154 grants. In FY20 alone, TC supported 120 Members (69% peer review funded) in all five Programs (CBE 18 %, CE 18 %, MM 31 %, HOB 5%, IO 28%). Collectively, TC supported 350 protocols during FY20. Of those protocols, 219 were clinical trials, increasing from 93 in FY2019 and 64 in FY2018.

项目摘要 组织核心 组织核心（TC）是莫菲特癌症中心（Moffitt）的中央生物座席。于1992年开放 TC的总体目标是收集，处理，存储和释放高质量的，良好的生物测量 支持基本，临床，人群，定量和翻译研究。 TC提供多种多样的 服务包括新鲜冷冻组织收集，组织学，免疫组织化学，核酸提取， 组织微阵列的产生和存档的生物测量释放。此外，TC同意并实施 特定于项目的SOP，包括研究设计和收集策略，以优化标本处理。 TC提供 75个符合或超过NCI最佳实践建议和帽子生物座的不同服务 认证标准，可确保样本收集和处理中的严格性和可重复性 通过标准化，文档和质量管理验证。实现目标的TC活动是 组织成三个具体目标： 目的1：作为集中的莫菲特生物库资源，用于收集，处理和存储 生物测量。 目标2：通过促进并确保通过 实施生物座席最佳实践。 目标3：通过简化的利用，生物测量教育和培训来丰富成员研究 确保高质量的结果。 在以前的资金周期中，TC服务继续提高效率，沟通和转机 Times和TC解决了标本集合的不断发展的复杂性，以支持新型项目。这 产生了三个新的服务部分：生物循环处理服务，TC全面癌症护理部分以支持 Moffitt的机构资助的生物库协议和TC临床试验生物测量服务，该服务提供 对临床试验的专用支持。此外，TC作为NIH财团项目的活跃网站合作 作为临床蛋白质组学肿瘤分析联盟，可提供生物测量收集，加工， 通过Moffitt的总癌症护理机构生物库协议传播和数据注释。也是TC 作为NHLBI国家骨髓增生综合症自然历史的中央实验室和生物座 学习。在过去的五年中，TC贡献了188个出版物（37个高影响力）和154个赠款。在20财年 单独的TC在所有五个计划中都支持120名成员（CBE 18％，CE 18％，MM 31 ％，HOB 5％，IO 28％）。总体而言，TC在第20财年期间支持了350个方案。在这些协议中，有219个是 临床试验，从2019财年的93和2018财年增加。