Tissue Core

项目总结 组织核心(TC)是莫菲特癌症中心(MCC)的中心生物储存库。开业于1992年， TC的总体目标是收集、处理、存储和释放高质量的、注释良好的生物样本，以支持 基础研究、人口研究、临床研究和转化研究。MCC的TC生物库活动主要有三个方面 具体目标： 1.作为集中的MCC生物库资源，用于收集、处理和存储人 支持成员科学的生物质谱学； 2.实施确保成员获得高质量的生物信息库最佳实践和质量指标 生物链霉菌； 3.制定和促进政策、指导方针和程序，以促进成员有效地接触人力资源 以符合监管规定的方式进行生物检疫。 TC位于一个2800平方英尺的设施中，由20名训练有素的生物库专家、工作人员 科学家、研究病理学家和经理共同支持研究人员驱动的研究和 一般银行业务。TC服务包含三个不同的部分：接收和获取、样本 加工实验室和研究组织学服务。这三个部分总共为206提供了支持 2015财年(2015财年)期间的协议。TC提供各种各样的服务，如收集新鲜的 冰冻组织，一般组织学，免疫组织化学，核酸提取，组织微阵列的构建 (TMA)，并释放存档的生物标本。此外，为支持由调查员主导的研究，TC 将特定需求和应用程序合并到特定于项目的SOP中，这通常包括为 研究设计和收集策略，以优化生物杀虫剂的处理。总体而言，TC提供了81个不同的 符合或超过NCI最佳实践建议和学院的生物库和生物质检相关服务 美国病理学家(CAP)生物信息库认可标准，以确保高质量的生物检验 通过标准化、文档化和对质量的重视来验证收集和处理 管理层。除了在过去五年中为173份出版物做出贡献外，TC的高质量 生物库基础设施对MCC成功的肺孢子、皮肤孢子、BMAP-3、TCGA和 CPTAC意见书。在之前的一段时间里，贸易委员会向成员们提供了重要的支持，这体现在 每年平均有近73,000个服务单位，其中2015财年的使用量达到了创纪录的85,708个服务单位 单位。在2015财年，分布在所有五个CCSG计划中的86个成员使用了TC服务，其中78% 同行评议资助成员的总使用量。

PROJECT SUMMARY The Tissue Core (TC) serves as the central biorepository for Moffitt Cancer Center (MCC). Opened in 1992, the overall goal of the TC is to collect, process, store, and release high-quality, well-annotated biospecimens in support of basic, population, clinical, and translational research. TC biobanking activities at MCC have three foremost specific aims: 1. Serve as a centralized MCC biobanking resource for the collection, processing, and storage of human biospecimens in support of member science; 2. Implement biorepository best practices and quality metrics that ensure members' access to high quality biospecimens; 3. Develop and promote policies, guidelines, and procedures that facilitate members' efficient access to human biospecimens in a regulatory-compliant manner. The TC is housed in a 2,800 square foot facility and staffed by 20 highly trained Biorepository Specialists, Staff Scientists, a Research Pathologist, and a Manager that collectively support investigator-driven studies and the general banking operations. TC services are housed within three distinct sections: Intake & Acquisition, Sample Processing Lab, and Research Histology Services. Collectively, the three sections provided support for 206 protocols during fiscal year 2015 (FY15). The TC provides a wide variety of services such as collection of fresh frozen tissue, general histology, immunohistochemistry, nucleic acid extraction, construction of tissue microarrays (TMA), and release of archived biospecimens. Moreover, in support of investigator-driven studies, the TC incorporates specific needs and applications into project-specific SOPs, which often include contributing to the study design and collection strategies to optimize biospecimen handling. Overall, the TC offers 81 distinct biobanking and biospecimen-related services that meet or exceed NCI best practice recommendations and College of American Pathologists (CAP) Biorepository Accreditation standards to ensure high-quality biospecimen collection and processing validated through standardization, documentation, and emphasis on quality management. In addition to contributing to 173 publications during the past five years, the TC's high-quality biobanking infrastructure was instrumental in MCC's successful Lung SPORE, Skin SPORE, BMaP-3, TCGA, and CPTAC submissions. During the prior period, the TC provided significant support to members, demonstrated by a yearly average of nearly 73,000 service units, with FY15 representing a record year of usage with 85,708 service units. In FY15, TC services were utilized by 86 members distributed across all five CCSG programs, with 78% of total usage by peer-review-funded members.