ImmunIGy: A Novel Pen-side Test for Checking Calf Immune Status, to increase the efficiency of beef production through supply chain feedback and improved management

ImmunIGy：一种用于检查小牛免疫状态的新型栏边测试，通过供应链反馈和改进管理来提高牛肉生产效率

• 批准号: 10052523
• 金额: $ 20.63万
• 依托单位: SYNERGY FARM HEALTH LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10052523
• 关键词: ImmunIGy; Novel; Pen; side; Test

Serum concentration of IgG in neonatal calves is a direct marker of the level of passive transfer of maternal antibody from colostrum. There is substantial evidence that successful passive transfer is associated with decreased morbidity and mortality rates, improved growth rates, feed conversion and lifetime productive capacity, whether the calf is destined to produce milk or enter the beef supply chain. As such, successful passive transfer is a key driver of economic and environmental efficiency on both dairy and beef farms rearing calves sourced from dairy units.ImmunIGy is a pen-side diagnostic test for measuring IgG in calves. It is novel for 2 reasons: firstly it is a Lateral Flow Test which can be carried out by the farmer, pen-side, and secondly the sample can be obtained by the farmer using a lancet on an insensitive part of the calf's nose. Hence the result can be obtained cheaply in the space of a few minutes.The project aims are to ;(a) Confirm that the output of the ImmunIGy test correlates with the current gold standard for measuring IgG, which will confirm its value for use in calves less than a week of age. (b) Determine if the measurement of IgG at collection centres for beef calves from the dairy herd can be used to predict future performance, both alone and when used to improve the function of a pre-existing Calf Algorithm. Such testing can drive improved efficiency of beef production via direct feedback to farms supplying calves with insufficient maternal immunity, pricing differentials and via bespoke management of calves according to their performance prediction. (c) Incorporate the algorithm into an App which will allow calf rearers to test calves on entry, enter the data to predict calf performance and put in place differential management practices, such as separate groups or a different threshold of disease prevalence before implementing antibiotic therapy. (d) Train the participating farmers in the use of the test, the App and the data that they need to provide whilst receiving feedback on its usability.

新生犊牛血清IgG浓度是母源抗体从初乳被动转移水平的直接标志。有大量证据表明，成功的被动转移与发病率和死亡率降低、生长率提高、饲料转化率和终生生产能力有关，无论小牛是注定要产奶还是进入牛肉供应链。因此，成功的被动转移是奶牛场和肉牛场提高经济和环境效益的关键驱动力。ImmunIGy是一种用于测量小牛IgG的笔侧诊断测试。其新颖性有两个原因：首先，它是一种横向流动测试，可以由农民在围栏边进行，其次，农民可以在小牛鼻子的不敏感部分上使用刺血针获得样品。该项目的目标是：（a）确认免疫y测试的输出与目前用于测量IgG的金标准相关，这将确认其在小于一周龄的小牛中的使用价值。(b)确定在奶牛群肉牛采集中心的IgG测量值是否可用于预测未来性能，无论是单独使用还是用于改善现有小牛算法的功能。这种测试可以通过直接反馈给提供母体免疫力不足的小牛的农场，价格差异以及根据小牛的性能预测对小牛进行定制管理来提高牛肉生产的效率。(c)将算法整合到应用程序中，允许小牛饲养者在进入时测试小牛，输入数据以预测小牛性能，并实施差异化管理实践，例如在实施抗生素治疗之前单独分组或不同的疾病流行阈值。(d)培训参与的农民使用测试，应用程序和他们需要提供的数据，同时收到关于其可用性的反馈。