EFR3: Novel gatekeeper of cell proliferation

EFR3：细胞增殖的新型看门人

• 批准号: DP240102729
• 负责人: Prof Janni Petersen
• 金额: $ 37.38万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102729
• 关键词: EFR3; Novel; gatekeeper; cell; proliferation

This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.

这个跨学科，跨机构的项目使用领先的质谱和酵母遗传模型，以提高真核细胞的细胞增殖共同的基本信号机制的知识。基于确定新的能量压力控制点的广泛的初步数据，这项研究将深入了解营养压力控制细胞增殖的关键和保守特征，以确保细胞存活。该项目促进基础和应用生物学。其成果将与几个研究领域和行业有关，特别是与细胞培养物的繁殖有关，细胞培养物如今有助于生产无数生物技术和制药商品。