Cancer Center Support Grant

总体：项目摘要 作为国家癌症研究所（NCI）指定的癌症中心在过去的45年里，维克森林浸信会 综合癌症中心（WFBCCC）一直是基础，转化，临床和人口的领导者- 基于癌症研究。WFBCCC解决了58个县区域内的重大癌症负担， 在北卡罗来纳州中部和西部，弗吉尼亚州西南部， 西弗吉尼亚州南部WFBCCC主任Boris Pasche，医学博士，博士和他的领导团队已经建立了一个 强大的跨学科中心，包括140名科学家。创新，高影响力的研究是由以下因素驱动的 WFBCCC的四个研究项目：癌症预防和控制，癌症遗传学和代谢， 信号转导和生物技术，以及神经肿瘤学。快速的发现和向有效的 翻译研究由九个共享资源支持。WFBCCC成功利用其NCI- 指定癌症中心的地位，以利用，扩大和提高中心的研究能力， 减少整个流域的癌症负担。作为一个研究基地， 对于NCI的社区临床肿瘤学研究计划，WFBCCC是全国领先的 推动美国各地创新癌症控制和癌症护理提供干预的机构。期间 在本项目期间，WFBCCC投资招聘了47名新的癌症重点教师， 癌症相关的同行评审研究的年度基数为2940万美元（不包括培训和职业发展） 其中1650万美元来自NCI。这两个数字分别比前一个数字增加了49%和57%。 退款此外，在本项目期间，所有干预性试验的应计费用增加了5倍以上。在2020年， 该中心招募了12,507人参加以癌症为重点的干预性研究，这是年度招募人数最多的一次 介入性研究的历史。此外，世界粮食理事会气候变化协调中心在以下方面取得了重大进展： 招募少数种族/族裔和居住在农村社区的个人参与研究。在2020年， 所有干预性临床试验参与者中有23.2%是少数种族/民族，所有个体中有近23%是少数种族/民族。 被招募者来自联邦政府指定为医疗服务不足的农村社区。这一成功是一个结果 多年的进步，WFBCCC领导的社区外展，参与和教育，继续 WFBCCC癌症健康公平办公室。还致力于培养下一代多样化的 癌症医生和生物医学和生物行为科学家，WFBCCC已经制定了一个全面的 癌症教育和培训管道为学习者在整个教育连续体。未来本 WFBCCC将以其2021-2026年战略计划为指导-从深思熟虑的内部和外部制定 纳入科学和社区观点的评估-以确保世界粮食理事会气候变化中心继续取得进展 科学发现，为理解癌症生物学和行为健康做出有影响力的贡献 在不同的人群中，并将这些发现转化为癌症护理的变革性方法。

OVERALL: PROJECT SUMMARY As a National Cancer Institute (NCI)-Designated Cancer Center for the past 45 years, Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) has been a leader in basic, translational, clinical, and population- based cancer research. WFBCCC addresses the significant cancer burden within a 58-county region, predominantly rural Appalachian regions within central and western North Carolina, southwestern Virginia, and southern West Virginia. The WFBCCC Director Boris Pasche, MD, PhD and his leadership team have built a robust, transdisciplinary center that includes 140 scientists. Innovative, high-impact research is driven by WFBCCC’s four research Programs: Cancer Prevention and Control, Cancer Genetics and Metabolism, Signaling and Biotechnology, and Neuro-Oncology. The rapid pace of discovery and movement toward effective translational research is supported by nine Shared Resources. WFBCCC successfully leverages its NCI- Designated Cancer Center status to harness, expand, and improve the Center’s research capabilities to decrease the cancer burden throughout its catchment area. Through its three-decade history as a research base for the NCI’s Community Clinical Oncology Research Program, WFBCCC is one of the nation’s leading institutions driving innovative cancer control and cancer care delivery interventions across the US. During the current project period, WFBCCC invested in the recruitment of 47 new cancer-focused faculty contributing to an annual base of cancer-relevant, peer-reviewed research of $29.4M (excluding training and career development awards), of which $16.5M is from the NCI. These are 49% and 57% increases, respectively, from the previous renewal. In addition, accrual to all interventional trials has increased more than 5-fold this project period. In 2020, the Center recruited 12,507 individuals to cancer-focused interventional studies, the highest annual recruitment to interventional studies in the history of WFBCCC. In addition, WFBCCC has made significant progress in recruiting racial/ethnic minorities and individuals residing in rural communities to participate in research. In 2020, 23.2% of all interventional clinical trial participants were racial/ethnic minorities, and nearly 23% of all individuals recruited were from rural communities federally designated as medically underserved. This success is a result of many years of progressive, WFBCCC-led community outreach, engagement, and education, which continue within the WFBCCC Office of Cancer Health Equity. Also committed to training the next generation of diverse cancer physicians and biomedical and biobehavioral scientists, the WFBCCC has developed a comprehensive cancer education and training pipeline for learners across the entire educational continuum. Going forward, the WFBCCC will be guided by its 2021-2026 Strategic Plan – developed from thoughtful internal and external evaluations incorporating scientific and community perspectives – to ensure WFBCCC continues to advance scientific discovery, make impactful contributions to the understanding of cancer biology and behavioral health within a diverse population, and translate these discoveries into transformative approaches to cancer care.