Cancer Center Support Grant

总体情况：项目总结 作为美国国家癌症研究所(NCI)指定的癌症中心，维克森林浸信会在过去的45年里 综合癌症中心(WFBCCC)在基础、转换、临床和人口方面一直处于领先地位- 以癌症研究为基础。WFBCCC解决了58个县地区内严重的癌症负担， 以阿巴拉契亚地区为主的中西部北卡罗来纳州、弗吉尼亚州西南部和 西弗吉尼亚州南部。WFBCCC主任Boris Pasche，医学博士和他的领导团队建立了一个 强大的跨学科中心，包括140名科学家。创新、高影响力的研究是由 WFBCCC的四个研究项目：癌症预防与控制，癌症遗传与代谢， 信号与生物技术，以及神经肿瘤学。快速发现并朝着有效的方向发展 翻译研究得到了九个共享资源的支持。WFBCCC成功地利用其NCI- 指定癌症中心地位，以利用、扩大和提高该中心的研究能力 减少整个集水区的癌症负担。通过其三十年的历史作为一个研究基地 对于NCI的社区临床肿瘤学研究计划，WFBCCC是全国领先的 推动全美创新癌症控制和癌症护理提供干预措施的机构。在.期间 在目前的项目期间，WFBCCC投资招聘了47名专注于癌症的新教师，为 每年2940万美元的癌症相关同行评议研究基数(不包括培训和职业发展 奖励)，其中1650万美元来自NCI。这分别比前一年增长了49%和57% 更新。此外，在本项目期间，所有干预性试验的应计费用增加了5倍以上。在2020年， 该中心招募了12,507人参加以癌症为重点的介入研究，这是年度招募人数最多的一次 WFBCCC历史上的干预性研究。此外，WFBCCC在以下方面取得了重大进展 招募少数族裔和居住在农村社区的个人参与研究。在2020年， 23.2%的干预性临床试验参与者是少数族裔，近23%的人 被招募的人来自被联邦指定为医疗服务不足的农村社区。这种成功是一种结果 WFBCCC领导的多年来不断进步的社区外展、参与和教育，这些活动仍在继续 在WFBCCC癌症健康公平办公室内。也致力于培养下一代多元化人才 癌症内科医生、生物医学和生物行为科学家，WFBCCC开发了一种全面的 在整个教育体系中为学习者提供癌症教育和培训渠道。展望未来， WFBCCC将以其2021-2026年战略规划为指导-从深思熟虑的内部和外部制定 纳入科学和社区观点的评估--确保WFBCCC继续前进 科学发现，为理解癌症生物学和行为健康做出重大贡献 并将这些发现转化为癌症护理的变革性方法。

OVERALL: PROJECT SUMMARY As a National Cancer Institute (NCI)-Designated Cancer Center for the past 45 years, Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) has been a leader in basic, translational, clinical, and population- based cancer research. WFBCCC addresses the significant cancer burden within a 58-county region, predominantly rural Appalachian regions within central and western North Carolina, southwestern Virginia, and southern West Virginia. The WFBCCC Director Boris Pasche, MD, PhD and his leadership team have built a robust, transdisciplinary center that includes 140 scientists. Innovative, high-impact research is driven by WFBCCC’s four research Programs: Cancer Prevention and Control, Cancer Genetics and Metabolism, Signaling and Biotechnology, and Neuro-Oncology. The rapid pace of discovery and movement toward effective translational research is supported by nine Shared Resources. WFBCCC successfully leverages its NCI- Designated Cancer Center status to harness, expand, and improve the Center’s research capabilities to decrease the cancer burden throughout its catchment area. Through its three-decade history as a research base for the NCI’s Community Clinical Oncology Research Program, WFBCCC is one of the nation’s leading institutions driving innovative cancer control and cancer care delivery interventions across the US. During the current project period, WFBCCC invested in the recruitment of 47 new cancer-focused faculty contributing to an annual base of cancer-relevant, peer-reviewed research of $29.4M (excluding training and career development awards), of which $16.5M is from the NCI. These are 49% and 57% increases, respectively, from the previous renewal. In addition, accrual to all interventional trials has increased more than 5-fold this project period. In 2020, the Center recruited 12,507 individuals to cancer-focused interventional studies, the highest annual recruitment to interventional studies in the history of WFBCCC. In addition, WFBCCC has made significant progress in recruiting racial/ethnic minorities and individuals residing in rural communities to participate in research. In 2020, 23.2% of all interventional clinical trial participants were racial/ethnic minorities, and nearly 23% of all individuals recruited were from rural communities federally designated as medically underserved. This success is a result of many years of progressive, WFBCCC-led community outreach, engagement, and education, which continue within the WFBCCC Office of Cancer Health Equity. Also committed to training the next generation of diverse cancer physicians and biomedical and biobehavioral scientists, the WFBCCC has developed a comprehensive cancer education and training pipeline for learners across the entire educational continuum. Going forward, the WFBCCC will be guided by its 2021-2026 Strategic Plan – developed from thoughtful internal and external evaluations incorporating scientific and community perspectives – to ensure WFBCCC continues to advance scientific discovery, make impactful contributions to the understanding of cancer biology and behavioral health within a diverse population, and translate these discoveries into transformative approaches to cancer care.