Visual Sciences Center of Biomedical Research Excellence

视觉科学生物医学卓越研究中心

• 批准号: 10334874
• 负责人: Visvanathan Ramamurthy
• 金额: $ 211.65万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10334874
• 关键词: Achievement; Address; Advisory Committees; Affect; Appalachian Region; Award; Behavior; Biochemistry; Biological; Biology; Biomedical Engineering; Brain; Centers of Research Excellence; Clinical; Collaborations; Communities; Complex; Core Facility; Coupled; Development; Disease; Effectiveness; Electroretinography; Ensure; Environment; Esthesia; Evaluation; Extramural Activities; Faculty; Faculty Recruitment; Feedback; Funding; Goals; Grant; Health; Health Sciences; Imaging technology; Incidence; Infrastructure; Institution; Investigation; Light; Mediating; Mentors; Microscope; Mind; Morphology; Motor; National Institute of General Medical Sciences; Network Infrastructure; Neurosciences; Ophthalmology; Opsin; Optical Coherence Tomography; Outcome; Patients; Pilot Projects; Population; Positioning Attribute; Prevention approach; Process; Program Effectiveness; Program Research Project Grants; Research; Research Infrastructure; Research Personnel; Research Support; Resolution; Rest; Retina; Retinal Ganglion Cells; Review Committee; Scientist; Sensory; Specific qualifier value; Strategic Planning; Structure; Synaptic Transmission; System; Talents; Technology; Time; Translating; Transmission Electron Microscopy; United States National Institutes of Health; Universities; Vesicle; Vision; Visual; Visual impairment; Visual system structure; West Virginia; Work; base; career; cell type; comorbidity; disability; effectiveness evaluation; formative assessment; instrumentation; interdisciplinary approach; meetings; member; multidisciplinary; novel strategies; professor; programs; recruit; response; senior faculty; single-molecule FRET; success; symposium; tenure track; tool; trafficking; vision science; visual information

PROJECT SUMMARY/ABSTRACT The overarching goal of the Visual Sciences CoBRE (VS-CoBRE) is to optimize infrastructure and mentoring to support a sustainable, multidisciplinary, and collaborative research environment at WVU around visual sciences. The establishment of the VS-CoBRE will strengthen the scientific community focused on understanding processes that are essential to visual health with the long-term goal of contributing to novel approaches for prevention and treatment of blinding diseases that disproportionately affect Appalachia's population. West Virginia has the 2nd highest rate of visual disability in the nation, and the incidence is projected to double by 2050. We will achieve our goals by completing the following aims: Aim1, Support Project Leaders (PLs) to achieve independent extramural funding; Aim 2, Promote the fundamental understanding of the visual system through optimizing relevant technical infrastructure; Aim 3, Promote a comprehensive, multidisciplinary approach to impactful visual sciences research; and Aim 4: Implement a rigorous strategy to evaluate the effectiveness of the VS-CoBRE towards promoting a robust center of excellence in visual sciences. With our existing strengths and research infrastructure network, coupled with the initiatives proposed in this VS-CoBRE, including mentoring of our four-promising junior PLs, we are well-positioned to achieve our goal. The creation of a center of excellence provides a venue for integrating efforts across the campus, including activities supported by NIGMS including the WV CTSI and other CoBREs, the clinical enterprise in the Department of Ophthalmology and Visual Sciences, and investigations led by basic biologists in the Departments of Biochemistry, Neuroscience, Biology, and the program in Biomedical Engineering. The VS-CoBRE will coalesce vision scientists around a common theme, enhance the intellectual environment, and cultivate cross collaborations. When the investigators proposed for support by this grant achieve independence by obtaining an R01-equivalent award, we will leverage the VS-CoBRE to recruit additional junior scientists whose work pertains to visual sciences. The core facilities and research infrastructure supported by the CoBRE will also allow our investigators to produce research results that will translate to patients, moving us toward our ultimate goal of reducing the burden of visual impairment and its comorbidities in the Appalachian region, throughout the nation, and worldwide.

项目摘要/摘要 Visual Sciences Cobre（VS-Cobre）的总体目标是优化基础架构和指导 支持WVU围绕视觉科学的可持续，多学科和协作研究环境。 VS-Cobre的建立将加强专注于理解的科学界 对于视觉健康至关重要的过程，其长期目标是为新颖的方法做出贡献 预防和治疗盲目疾病，对阿巴拉契亚人口的影响不成比例。西方 弗吉尼亚州的视觉残疾率是全国第二高，预计到2050年的发病率将翻一番。 我们将通过完成以下目标来实现我们的目标：AIM1，支持项目负责人（PLS）以实现 独立的壁外资金； AIM 2，通过 优化相关的技术基础设施；目标3，促进一种全面的多学科方法 有影响力的视觉科学研究；目标4：实施严格的策略来评估 VS-Cobre旨在促进视觉科学卓越的卓越中心。我们现有的优势 以及研究基础设施网络，再加上此案中提出的倡议，包括指导 在我们四个宣传的初级PL中，我们有很好的位置来实现我们的目标。建立一个中心 卓越为整合整个校园的努力提供了一个场所，包括Nigms支持的活动 包括WV CTSI和其他Cobres，即眼科和视觉部的临床企业 科学和由生物化学，神经科学，生物学，生物学部门的基本生物学家领导的调查 以及生物医学工程的计划。 VS-Cobre将围绕一个共同的愿景科学家聚集 主题，增强智力环境并培养交叉协作。当调查人员时 通过获得R01等效奖励，这笔赠款提出的支持实现了独立性，我们将利用 与视觉科学有关的其他初级科学家招募了其他初级科学家。核心设施 毛c支持的研究基础设施还将允许我们的研究人员产生研究结果 这将转化为患者，将我们迈向减轻视觉障碍负担的最终目标 及其在阿巴拉契亚地区，全国和全球的合并症。