Core C: Comparative Pathology Core
核心 C:比较病理学核心
基本信息
- 批准号:10333804
- 负责人:
- 金额:$ 30.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-02-15 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAlgorithmsAnimal ExperimentsAnimal ModelAnimalsArchivesAutopsyBiologicalBiological MarkersBiological ProcessCanis familiarisCarbonCellsClassificationClinicalCollaborationsCollectionComparative PathologyComputer softwareConsultationsDataDevelopmentEnsureEpithelialEvaluationFibrosisGoalsGrowthHematoxylin and Eosin Staining MethodHistological TechniquesHistologyHistopathologyImage AnalysisImmuneImmunofluorescence ImmunologicImmunohistochemistryIn Situ HybridizationInflammationInflammatoryInfrastructureLabelLaboratoriesLesionMalignant - descriptorMeasurableMethodsModalityModernizationMolecularMorphologyMusNormal tissue morphologyOutcomeParaffin EmbeddingPathologicPathologistPathologyPatientsPhenotypePlayPopulationPre-Clinical ModelPreparationProceduresProtocols documentationProtonsRadiation therapyReproducibilityResearch DesignResearch PersonnelRodentRoleRouteSamplingServicesSeveritiesSignal PathwaySirius Red F3BSlideSolidSpecimenStainsStandardizationStructureSystemT-LymphocyteTechniquesTechnologyTestingTherapeutic IndexTimeTissue SampleTissuesToxic effectTrainingTranslationsTrichrome stain methodTumor-infiltrating immune cellsVariantWorkanimal tissuebasecytokinedigital imagingdigital pathologyexperiencefunctional statusimmunological statusinterestmacrophageneoplasticneoplastic cellneutrophilparticlepathology imagingpersonalized approachpre-clinicalpreclinical studypreservationprogramsresponsetissue preparationtooltranslational studytumortumor microenvironmentwhole slide imaging
项目摘要
Project Summary
The study of the preclinical animal models included in all four Projects plays a critical role to investigate the
overall hypothesis that Proton/Carbon Particle FLASH Radiotherapy is superior to Standard Particle
Radiotherapy in protecting normal tissues while maintaining equipotent malignant growth control. The
extrapolation of robust preclinical data in these experimental settings relies heavily on the unbiased
assessment of specific histopathological parameters to investigate the biological effects of FLASH particle
radiotherapy as compared to Standard particle radiotherapy on designated neoplastic lesions and adjacent
normal tissues. The Comparative Pathology Core (CPC; Core C) will provide its expertise contributing to the
planning, evaluation, and interpretation of the pathology endpoints of the animal experiments included in the
Projects. As a PennVet clinical laboratory, Core C importantly follows standardized working protocols with strict
QA/QC procedures. The histopathology service offered by Core C will ensure accurate collection, proper
preservation, timely processing, and staining of the animal specimens. Core C will provide the necessary
technical support and submissions of tissue samples will follow a prioritized route. In addition to standard
histopathology, Core C will also develop and validate tailored approaches to investigate and quantify tissue
changes specifically associated with RT such as fibrosis, intralesional distribution of inflammatory/immune cell
populations, expression of markers to evaluate epithelial barrier integrity, etc. The board-certified veterinary
pathologists of Core C will deliver expert evaluation and unbiased interpretation of the pathology endpoints.
Objective and reproducible quantification of tissue changes in response to the diverse RT modalities will be
guaranteed by the application of validated scoring systems and the utilization of software-based algorithms
for digital pathology and image analysis. Core pathologists have advanced training in digital imaging pathology
from Leica pathology systems. Moreover, Dr. Assenmacher has collaborated with Leica in the development
of analysis tools, lending him particular experience in the analytic modules of the digital pathology system.
项目总结
项目成果
期刊论文数量(0)
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