Functional tomography of neurovascular coupling interactions in healthy and diseased retinas
健康和患病视网膜神经血管耦合相互作用的功能断层扫描
基本信息
- 批准号:10334551
- 负责人:
- 金额:$ 30.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAdvanced DevelopmentAge related macular degenerationAlgorithmsAlzheimer&aposs DiseaseAngiographyAppearanceArteriesBlindnessBloodBlood VesselsBlood capillariesBrainCaliberCharacteristicsCorneaDefectDementiaDetectionDevelopmentDiabetic RetinopathyDiseaseDropoutEarly DiagnosisEarly treatmentEvaluationFosteringFunctional ImagingFunctional disorderGanglion Cell LayerGanglionic LayerGlaucomaHealthImageInterventionLightingMedicalMethodsMonitorMorphologic artifactsMorphologyMusNerveNerve DegenerationNeurodegenerative DisordersNutrientOphthalmologyOptical Coherence TomographyOpticsOxygenOxygen ConsumptionOxygen saturation measurementParkinson DiseasePathologyPhasePhotoreceptorsPrevention strategyResolutionRetinaRetinal DegenerationRetinal DiseasesRetinal Ganglion CellsRetinal PhotoreceptorsRetinitis PigmentosaScanningSignal TransductionSourceSpeedStimulusSystemThickThinnessTreatment ProtocolsVasodilationVeinsadaptive opticsarterioledensitydigitalhemodynamicsimaging platformindexinginstrumentneuron lossneurovascularneurovascular couplingnon-invasive imagingrelating to nervous systemresponseretinal imagingspatiotemporalsuccesstherapy developmenttomographytwo-dimensionalvenule
项目摘要
Project summary: This project is to investigate spatiotemporal interactions between neural activities and
hemodynamic changes in the retina, and to explore quantitative mapping of retinal neurovascular coupling
defects caused by neurodegenerative diseases. Retinal neurodegenerative diseases, such as age-related
macular degeneration (AMD), retinitis pigmentosa (RP), diabetic retinopathy (DR) and glaucoma, can produce
severe vision losses if medical interventions cannot be provided promptly. As one part of the central never system
(CNS), the retina is also targeted by other neurodegenerative diseases, such as Parkinson's and Alzheimer's
diseases which are the major cause of dementia. Early detection of these neurodegenerative diseases is
essential for better study and development of preventive strategies. Functional imaging of neurovascular
coupling defects promises early detection of neurodegeneration. Direct access to the brain for high-resolution
examination of neurovascular coupling defects is difficult. The retina opens a window for high-resolution study
of neurovascular coupling defects. This project is to explore spatiotemporal mapping of three-dimensional (3D)
interactions between neural activities and hemodynamic changes. The first aim of this project is to refine our
existing spectral-domain optical coherence tomography (OCT), and to extend our recently demonstrated swept-
source parallel OCT to a multi-functional parallel OCT (MF-P-OCT) instrument, which will provide 5 µm spatial
resolution and 5 ms OCT volume speed. The MF-P-OCT will enable functional OCT of stimulus-evoked neural
activities and functional OCT angiography (OCTA) of microvascular responses simultaneously. The second aim
is to investigate retinal neurovascular defects in retinal degeneration rd10 and APPswe/PSEN1dE9 mice, in
which outer retina (photoreceptor) and inner retina (ganglion) are degenerated first, respectively. Morphological
OCT and OCTA features, including retinal thickness, blood vessel caliber (BVC), blood vessel tortuosity (BVT),
vessel perimeter index (VPI), and blood vessel density (BVD) will be quantitatively compared in normal and
diseased mice. Comprehensive analysis of stimulus-evoked vasodilation, transient blood and oxygen changes
will be used for in-depth understanding of blood/oxygen consumption at the capillary level in normal and diseased
retinas. Concurrent monitoring of stimulus-evoked intrinsic optical signals (IOSs) correlated with neural activity
(i.e., neural-IOS) and vascular response (i.e., hemodynamic-IOS) will be used for objective evaluation of spatial
and temporal characteristics of neurovascular coupling interactions in the retina. The key success criterion of
this project is to verify functional detection of neurovascular coupling defects (i.e., distorted stimulus-evoked
hemodynamics at capillary level), before the appearance of detectable morphological abnormalities (i.e.,
neuronal loss and vessel dropout). Success in this project will produce a noninvasive imaging platform for high-
resolution and objective assessment of functional relationship between neural degeneration and vascular
pathology, promoting early detection and therapy development of neurodegeneration diseases.
项目摘要:该项目旨在研究神经活动和神经元之间的时空相互作用。
视网膜的血流动力学变化,并探索视网膜神经血管耦合的定量映射
神经退行性疾病引起的缺陷。视网膜神经退行性疾病,例如与年龄相关的
黄斑变性 (AMD)、色素性视网膜炎 (RP)、糖尿病性视网膜病变 (DR) 和青光眼,可产生
如果不能及时提供医疗干预,视力会严重丧失。作为中央从不系统的一部分
(中枢神经系统),视网膜也是其他神经退行性疾病的目标,例如帕金森氏症和阿尔茨海默氏症
是导致痴呆症的主要原因的疾病。早期发现这些神经退行性疾病是
对于更好地研究和制定预防策略至关重要。神经血管功能成像
耦合缺陷有望及早发现神经退行性变。直接进入大脑以获得高分辨率
神经血管耦合缺陷的检查很困难。视网膜为高分辨率研究打开了一扇窗户
神经血管耦合缺陷。该项目旨在探索三维(3D)的时空映射
神经活动和血流动力学变化之间的相互作用。该项目的首要目标是完善我们的
现有的谱域光学相干断层扫描(OCT),并扩展我们最近证明的扫频
源并行 OCT 到多功能并行 OCT (MF-P-OCT) 仪器,该仪器将提供 5 µm 空间
分辨率和 5 ms OCT 体积速度。 MF-P-OCT 将实现刺激诱发神经的功能性 OCT
活动与功能性OCT血管造影(OCTA)的微血管反应同时进行。第二个目标
目的是研究视网膜变性 rd10 和 APPswe/PSEN1dE9 小鼠的视网膜神经血管缺陷,
其中外层视网膜(感光器)和内层视网膜(神经节)分别首先退化。形态学
OCT 和 OCTA 特征,包括视网膜厚度、血管口径 (BVC)、血管迂曲度 (BVT)、
血管周长指数(VPI)和血管密度(BVD)将在正常和正常情况下进行定量比较
患病的老鼠。综合分析刺激引起的血管舒张、短暂的血氧变化
将用于深入了解正常和患病患者毛细血管水平的血液/氧气消耗
视网膜。同时监测与神经活动相关的刺激诱发的内在光信号 (IOS)
(即神经-IOS)和血管反应(即血流动力学-IOS)将用于空间的客观评估
视网膜神经血管耦合相互作用的时间特征。关键成功标准
该项目旨在验证神经血管耦合缺陷(即扭曲的刺激诱发
毛细血管水平的血流动力学),在出现可检测到的形态异常之前(即,
神经元损失和血管脱落)。该项目的成功将产生一个无创成像平台,用于高
神经变性与血管功能关系的解析和客观评估
病理学,促进神经退行性疾病的早期发现和治疗发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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XINCHENG YAO其他文献
XINCHENG YAO的其他文献
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{{ truncateString('XINCHENG YAO', 18)}}的其他基金
Functional tomography of neurovascular coupling interactions in healthy and diseased retinas
健康和患病视网膜神经血管耦合相互作用的功能断层扫描
- 批准号:
9892006 - 财政年份:2019
- 资助金额:
$ 30.35万 - 项目类别:
Super-resolution ophthalmoscopy for in vivo retinal imaging
用于体内视网膜成像的超分辨率检眼镜
- 批准号:
8975948 - 财政年份:2015
- 资助金额:
$ 30.35万 - 项目类别:
Angle-resolved polarization signal imaging of early receptor potential
早期受体电位的角度分辨偏振信号成像
- 批准号:
8112263 - 财政年份:2011
- 资助金额:
$ 30.35万 - 项目类别:
Angle-resolved polarization signal imaging of early receptor potential
早期受体电位的角度分辨偏振信号成像
- 批准号:
8248279 - 财政年份:2011
- 资助金额:
$ 30.35万 - 项目类别:
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