Core A: Administrative Core

核心A：行政核心

• 批准号: 10333658
• 负责人: John M Sedivy
• 金额: $ 4.14万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10333658
• 关键词: Age; Aging; Alzheimer' s Disease; Applications Grants; Attention; Biology; Cell Line; Chronic; Collaborations; Communication; Communities; Complementary DNA; Consensus; DNA Damage; Data Set; Databases; Dementia; Deposition; Development; Disease; Ensure; Evaluation Research; Genome; Goals; Host Defense Mechanism; Inflammaging; Inflammation; Information Dissemination; Innate Immune System; Insertional Mutagenesis; Institutes; Institution; Interferon Type I; Joints; L1 Elements; Lead; Leadership; Mediation; Mentors; Modeling; Molecular; Monitor; Nerve Degeneration; Neuraxis; Neurodegenerative Disorders; Nucleosides; Process; Progress Reports; Protocols documentation; Publications; Reagent; Recommendation; Regulation; Repetitive Sequence; Reporter; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Resources; Retrotransposition; Retrotransposon; Reverse Transcriptase Inhibitors; Role; Services; Site; Sterility; Technology; Time; Training; Transcript; United States National Institutes of Health; Writing; age related; base; conflict resolution; data submission; design; high standard; inhibitor therapy; meetings; member; mouse model; new technology; novel; programs; public database; recruit; response; tool; translational potential

PROJECT SUMMARY (CORE A) The overall goals of the Administrative Core (Core A) are to provide scientific, programmatic and fiscal leader- ship, facilitate lines of communication between the different researchers involved in the PPG, maintain cohe- rence in the PPG’s overall and long-range goals, and ensure that resources resulting from the PPG will benefit the scientific community. Core A will thus provide the mechanisms to manage, evaluate, and evolve the four Research Projects and two Research Cores in the program. In the context of the above, the task of Core A will be the effective coordination of the activities of all the components, such as the selection and design of jointly used models and resources (cell lines, mouse models, transposon reporters, protocols, etc.), the development of new technologies and tools to more effectively promote the research goals, and enabling the scientific community access to the PPG’s resources, technologies, and databases. The following activities will also contribute to achieving these overall goals: 1) Core A will ensure that the administrative and financial requirements of the NIH and the participating institutions are met; 2) Core A will organize monthly videoconferences and annual face-to-face retreats; 3) Core A will be responsible for communications between the PPG and the NIH; 4) Core A will facilitate the submission of joint publications and, in collaboration with Core B, the deposition of high-throughput datasets into public databases; 5) Core A will establish the External Advisory Board (EAB) and organize the annual reviews of the PPG.

项目概要（核心A） 行政核心（核心A）的总体目标是提供科学、方案和财政领导， 船舶，促进参与PPG的不同研究人员之间的沟通渠道，保持协调， 在PPG的总体和长期目标中的作用，并确保PPG产生的资源将受益 科学界。因此，核心A将提供管理、评估和发展这四个方面的机制。 研究项目和两个研究核心的计划。在上述背景下，核心A的任务将 有效协调所有组成部分的活动，如联合选择和设计 使用的模型和资源（细胞系、小鼠模型、转座子报告基因、方案等），发展 新技术和工具，以更有效地促进研究目标，并使科学 社区访问PPG的资源，技术和数据库。以下活动还将 （a）核心A将确保行政和财务方面的工作， 符合NIH和参与机构的要求; 2）核心A将每月组织一次 视频会议和年度面对面务虚会; 3）核心A将负责 4）核心A将促进联合出版物的提交，并与核心A合作， B，将高通量数据集存入公共数据库; 5）核心A将建立外部咨询 理事会（EAB），并组织项目规划小组的年度审查。