Genetic Regulatory Network in Craniofacial Development
颅面发育中的遗传调控网络
基本信息
- 批准号:10337244
- 负责人:
- 金额:$ 66.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Abnormal CellAdultAffectAnimal ModelApoptosisBone DevelopmentBone DiseasesBone RegenerationCalvariaCartilageCellsCharacteristicsChildhoodChondrocraniumCongenital abnormal SynostosisCraniofacial AbnormalitiesCraniosynostosisDataDefectDeformityDevelopmentDiseaseDysplasiaEngraftmentEtiologyEvaluationExhibitsFGFR1 geneFibroblast Growth FactorFibrous capsule of kidneyGenesGeneticGenomicsGrowthHealthHomeostasisHumanHuman DevelopmentHuman GeneticsImplantIndividualInfantInjuryInvestigationJoint structure of suture of skullKnockout MiceLaboratoriesLentivirusLinkMaintenanceMediatingMesenchymeMolecularMorphogenesisMouse StrainsMusMutationNatural regenerationOsteoblastsOsteocytesOsteogenesisPathogenesisPathway interactionsPatientsPfeiffer SyndromePhysiologic OssificationPlayProteinsRegulationRepressionRoleSignal PathwaySignal TransductionSiteSkeletonSupporting CellSurgical suturesTestingTherapeuticTissuesTransplantationTyrosinebonebone healingbone repaircell typecraniofacialcraniofacial bonecraniofacial developmentcraniumgenetic analysisgenetic elementhuman diseaseimplantationin vivoinducible gene expressioninjuredinsightintramembranous bone formationmalformationmouse geneticsmouse modelnovelosteoblast differentiationosteoblast proliferationosteogenicprematurereceptorrepairedreparative capacityself-renewalskeletalskeletal regenerationskeletal stem cellskeletogenesisstem cell divisionstem cell nichestem cell populationstem cellsstemnessubiquitin-protein ligase
项目摘要
Title
Genetic Regulatory Network in Craniofacial Development
Abstract
This proposal continues our efforts to decipher the skeletogenic signaling network underlying craniofacial
development and disease. The craniofacial skeleton consists of viscerocranium and neurocranium, which is
subdivided into the calvarium and chondrocranium. During development of the calvarium, cranial sutures serve
as the growth center for skeletogenesis. Defects in suture morphogenesis resulting in premature closure cause
craniosynostosis, a devastating childhood disease affecting 1 in ~2,500 individuals. Although human genetic
analyses have identified genes associated with the pathogenesis, little is known about the regulation of suture
closure essential for development of a healthy skull. In the previously proposed investigation, we have
elucidated the mechanisms by which Axin2 regulates suture morphogenesis through modulations of Wnt and
downstream signaling pathways. The crosstalk of BMP and FGF signaling plays a pivotal role in Wnt-mediated
craniofacial bone development. Furthermore, skeletal stem cells residing in the suture mesenchyme have been
successfully identified and isolated in our laboratory. This suture stem cell (SuSC) population is responsible for
calvarial development in infants as well as homeostatic maintenance in adults. Upon injury, the dormant
SuSCs respond quickly and contribute directly to bone repair in a cell autonomous fashion. In vivo clonal
analysis demonstrates calvarial bone regeneration at a single cell level. Implantation of SuSCs to an injured
site shows not only long-term survival but also facilitation of bone healing via direct engraftments in which the
implanted stem cells give rise to osteogenic cell types in replacement of the damaged tissue. The newly
discovered SuSCs thus provides an outstanding opportunity to gain novel insights into etiology of
craniosynostosis. In this proposal, we continue our in-depth evaluations of SuSCs by examining their
regulation essential for healthy development and homeostasis of the calvarium. We will concentrate on
elucidation of molecular and cellular mechanisms underlying craniosynostosis caused by dysregulation of
SuSCs.
标题
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wei Hsu其他文献
Wei Hsu的其他文献
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{{ truncateString('Wei Hsu', 18)}}的其他基金
Nonclassical β-catenin signaling in odontogenesis
牙发生中的非经典β-连环蛋白信号传导
- 批准号:
10714280 - 财政年份:2023
- 资助金额:
$ 66.21万 - 项目类别:
Genetic Regulatory Network in Craniofacial Development
颅面发育中的遗传调控网络
- 批准号:
10547798 - 财政年份:2021
- 资助金额:
$ 66.21万 - 项目类别:
Genetic Regulatory Network in Craniofacial Development
颅面发育中的遗传调控网络
- 批准号:
10440858 - 财政年份:2021
- 资助金额:
$ 66.21万 - 项目类别:
Stem cells for craniofacial bone repair and regeneration
用于颅面骨修复和再生的干细胞
- 批准号:
10440848 - 财政年份:2021
- 资助金额:
$ 66.21万 - 项目类别:
Stem cells for craniofacial bone repair and regeneration
用于颅面骨修复和再生的干细胞
- 批准号:
10473883 - 财政年份:2021
- 资助金额:
$ 66.21万 - 项目类别:
Stem cells for craniofacial bone repair and regeneration
用于颅面骨修复和再生的干细胞
- 批准号:
9927910 - 财政年份:2018
- 资助金额:
$ 66.21万 - 项目类别:
Genetic Regulatory Network in Craniofacial Development
颅面发育中的遗传调控网络
- 批准号:
8667323 - 财政年份:2006
- 资助金额:
$ 66.21万 - 项目类别:
GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
颅面发育中的遗传调控网络
- 批准号:
7835696 - 财政年份:2006
- 资助金额:
$ 66.21万 - 项目类别:
GENETIC REGULATORY NETWORK IN CRANIOFACIAL DEVELOPMENT
颅面发育中的遗传调控网络
- 批准号:
7626374 - 财政年份:2006
- 资助金额:
$ 66.21万 - 项目类别:
Genetic Regulatory Network in Craniofacial Development
颅面发育中的遗传调控网络
- 批准号:
8481531 - 财政年份:2006
- 资助金额:
$ 66.21万 - 项目类别:
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