Regulatory control of inflammatory cytokine production by a linear ubiquitin-binding protein
线性泛素结合蛋白对炎症细胞因子产生的调节控制
基本信息
- 批准号:10337076
- 负责人:
- 金额:$ 7.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-02 至 2022-07-29
- 项目状态:已结题
- 来源:
- 关键词:AcademiaAdvisory CommitteesAffectAnti-Inflammatory AgentsApoptosisApoptoticAutoimmune DiseasesAutoimmunityBindingBinding ProteinsBiological ProcessBiological Response ModifiersBiologyCASP8 geneCRISPR/Cas technologyCSF3 geneCell DeathChronic DiseaseClinical PathologyClinics and HospitalsCommunicable DiseasesComplexCore FacilityDendritic CellsDiseaseDoctor of MedicineDoctor of PhilosophyEnvironmentEquilibriumFive-Year PlansGene DeletionGenesGeneticGenetic PolymorphismHealthHomeostasisHumanIRAK1 geneIRAK4 geneImmuneImmune System DiseasesImmunityImmunodeficiency and CancerImmunologic ReceptorsIn VitroIndustryInflammationInflammatoryInflammatory ResponseInflammatory Response PathwayInnate Immune ResponseInnate Immune SystemInstitutionInterleukin-1 ReceptorsInterleukin-6JointsKnock-inKnockout MiceLigandsLightLinkMAP Kinase GeneMediatingMentorsMentorshipModelingMolecularMusNF-kappa BNatural ImmunityOutputPathway interactionsPattern recognition receptorPhysiciansPoint MutationPolyubiquitinPost-Translational Protein ProcessingProductionProteinsRIPK1 geneReceptor SignalingRegulationResearchResearch PersonnelResearch ProposalsResidenciesResistanceResourcesRibonucleasesRoleScientistSeriesSeveritiesSignal PathwaySignal TransductionSyndromeSystemTLR1 geneTLR3 geneTLR4 geneTLR7 geneTNF geneTNFRSF5 geneTestingTherapeuticTimeToll-like receptorsTrainingTumor Necrosis Factor ReceptorUbiquitinUbiquitinationUniversitiesautoinflammatorycareercareer developmentcell typecytokinedisease-causing mutationexperimental studyin vivoinhibitorlaboratory facilitymacrophagemedical schoolsmouse modelmutantmutant mouse modelnovelnovel strategiesprogramsreceptorrecruitresponse
项目摘要
PROJECT SUMMARY/ABSTRACT
This proposal outlines a five-year plan for the PI, Dr. Alexander Gitlin, to prepare him for an independent
academic career as a physician-scientist. Dr. Gitlin received his M.D./Ph.D. degrees from the Weill
Cornell/Rockefeller/Sloan-Kettering Tri-Institutional M.D.-Ph.D. program and is currently completing residency in
Clinical Pathology at Stanford Hospital and Clinics. During residency, Dr. Gitlin developed a jointly mentored
research program, co-advised by Drs. Bali Pulendran (Stanford University) and Vishva Dixit (Genentech, Inc.).
Drs. Pulendran and Dixit are longtime colleagues and collaborators with highly complementary expertise. Dr.
Pulendran is an expert in toll-like receptors, innate immunity, and dendritic cells; Dr. Dixit is an expert on
inflammatory signaling, cell death, and ubiquitin biology. Both Drs. Pulendran and Dixit have served as mentors
to numerous trainees, many of whom have become leading investigators in academia or industry. This joint
mentorship program provides Dr. Gitlin with full access to the combined resources and expertise present at two
neighboring, world-class research institutions, Stanford University and Genentech, which will provide
outstanding environments for Dr. Gitlin to develop his own independent scientific career. In addition, Dr. Gitlin
has assembled a K08 advisory committee composed of senior investigators whose scientific expertise and
mentorship will greatly aid Dr. Gitlin’s career development. They include Drs. Stephen Galli, Denise Monack,
Scott Boyd, and Andrey Shaw. Furthermore, Dr. Gitlin will have access to coursework, retreats, seminars and
resources through Stanford University’s School of Medicine, The Stanford Office of Postdoctoral Affairs, and the
Genentech Postdoctoral Program. Finally, the scientific resources available to Dr. Gitlin comprise the
Pulendran/Dixit laboratories and core facilities at both Stanford University and Genentech, representing an
extraordinary set of scientific resources. The research proposal detailed herein seeks to uncover the molecular
mechanisms by which linear ubiquitin controls the magnitude of the innate immune response. Dysregulated
inflammatory and cytokine responses are fundamental features of multiple chronic diseases, including
autoimmunity, autoinflammatory syndromes, infectious diseases, immunodeficiencies and cancer. Yet, many of
the complex signaling pathways that regulate inflammatory signaling are still being unraveled at a mechanistic
level. During Dr. Gitlin’s short time as a co-mentee of Drs. Dixit and Pulendran, he has discovered that the
NEDD4-binding protein 1 (N4BP1), a linear ubiquitin-binding protein, is a novel regulator of toll-like receptor
(TLR) responses. In Aim 1, we will test the hypothesis that N4BP1 differentially regulates inflammatory cytokine
production downstream of TLR signaling. In Aim 2, we will dissect the mechanistic basis of N4BP1 activity by
inactivating its independent functional motifs. We anticipate these studies will elucidate a novel pathway by which
a previously enigmatic linear ubiquitin-binding protein selectively controls the cytokine output of TLRs. These
studies provide an excellent platform for Dr. Gitlin to complete his training and launch his independent career.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexander Gitlin其他文献
Alexander Gitlin的其他文献
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{{ truncateString('Alexander Gitlin', 18)}}的其他基金
Regulation of Proinflammatory Cytokine Responses by a Caspase-8-N4BP1 Axis
Caspase-8-N4BP1 轴对促炎细胞因子反应的调节
- 批准号:
10704065 - 财政年份:2022
- 资助金额:
$ 7.69万 - 项目类别:
Regulatory control of inflammatory cytokine production by a linear ubiquitin-binding protein
线性泛素结合蛋白对炎症细胞因子产生的调节控制
- 批准号:
10674329 - 财政年份:2021
- 资助金额:
$ 7.69万 - 项目类别:
Molecular Regulation of Germinal Center B Lymphocytes
生发中心 B 淋巴细胞的分子调控
- 批准号:
8649227 - 财政年份:2014
- 资助金额:
$ 7.69万 - 项目类别:
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