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BLRD Research Career Scientist Award Application

BLRD Research Career Scientist Award Application
BLRD 研究职业科学家奖申请
批准号:
10337064
负责人:
Andres Vazquez-Torres
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-10-01 至 2025-09-30
关键词:
Alzheimer&aposs DiseaseAmino AcidsAminoglycoside resistanceAminoglycosidesAnabolismAntibiotic ResistanceAntibioticsAwardBacteremiaBacteriaBacterial Antibiotic ResistanceBindingBloodBurkholderia pseudomalleiCell WallCell divisionCenters for Disease Control and Prevention (U.S.)Cessation of lifeClinicalCollaborationsColoradoComplexComplicationCytochromesDNA-Directed RNA PolymeraseDevelopmentDiarrheaElectron TransportEnzymesEscherichia coliEvolutionExcretory functionFacultyFamilyFosteringFundingGenetic TranscriptionGoalsGrantGrowthGuanosine TetraphosphateHIVHealthHealthcare SystemsImmunologic Deficiency SyndromesIndividualInfectionInflammation MediatorsInternationalInvestigationJournalsKnowledgeLegal patentMediatingMediator of activation proteinMedical centerMentorsMetabolicMetabolic PathwayMetabolismMilitary PersonnelMissionMolecularMonitorMonobactamsMulti-Drug ResistanceNADPH OxidaseNOS2A geneNatureNitric OxideNucleotidesOxidation-ReductionPaperParkinson DiseasePathogenesisPatientsPersonsPhagocytesPharmaceutical PreparationsPlayPoisonPoisoningPostdoctoral FellowProtein BiosynthesisProteinsPublishingPurinesRegulationReportingResearchResearch PersonnelResearch Project GrantsResistanceRodRoleSalmonellaSalmonella infectionsSamplingScheduleScienceScientistSecondary toSeminalSiteSystemTrainingTranscriptional Elongation FactorsTranslatingTranslationsTubulinType III Secretion System PathwayUnited States Department of Veterans AffairsUniversitiesVeteransVirulenceWisconsinWorkWorld Health Organizationabsorptionantibiotic toleranceantimicrobialbasebeta-Lactamscareerenteric pathogenfundamental researchglobal healthgraduate studentimprovedmacrophagemicrobialmisfolded proteinnext generationnovelnovel therapeuticspathogenpathogenic bacteriapreclinical studyprogramsrational designresponsetraining opportunitytranscription factor

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中文摘要
翻译
据估计,全世界每年有300万人死于沙门氏菌感染。耐多药
英文摘要
Salmonella infections are responsible for an estimated 3 million annual deaths worldwide. Multidrug resistance among clinical Salmonella more than doubled from 2011 to 2013. The World Health Organization has ranked Salmonella as one of the top 12 antibiotic resistant bacterial threats to global health. The goal of this Research Career Scientist Award is to continue with our efforts to apply our knowledge of Salmonella virulence to the development of novel antibiotics against multidrug resistant bacterial pathogens. Resistance of Salmonella and other pathogenic bacteria to antibiotics is in great part regulated by the nucleotide alarmone guanosine tetraphosphate and the DksA protein. Both of these mediators bind to the secondary channel of RNA polymerase, regulating transcription of central metabolic pathways and a variety of virulence programs. We will carry on our research on the molecular mechanisms by which guanosine tetraphosphate and DksA regulate Salmonella transcriptional programs. The Research Career Scientist Award will also allow us to develop novel antibiotics that inhibit DksA-dependent bacterial transcription. Binding of DksA to the secondary channel of RNA polymerase is in competition with Gre transcription elongation factors. We have found that Gre proteins are needed for Salmonella virulence and the resistance of this Gram-negative rod to antibiotics. We plan to characterize the molecular mechanisms by which Gre factors promote bacterial pathogenesis and antibiotic resistance. These research projects are highly collaborative in nature, involving scientific interactions with investigators at the Veterans Affairs Eastern Colorado Healthcare System, the Atlanta VA Medical Center and the Veterans Administration Ann Arbor Healthcare System. I plan to continue fostering these productive collaborations. Training of junior faculty, graduate students and postdoctoral fellows are also important components of this Research Career Scientist Award. Moreover, in collaboration with other investigators at the at the Veterans Affairs Eastern Colorado Healthcare System and Wisconsin-Madison VA Medical Center, we will continue mentoring promising CDA- 2 candidates, and thus help train the next generation of outstanding VA scientists.
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会议论文
Development of DksA-targeted Antibiotics for Treatment of Gram-negative Infections
BLRD Research Career Scientist Award Application
Analysis of regulatory networks in Salmonella pathogenesis.
  • 批准号:
    10468174
  • 项目类别:
  • 资助金额:
    $49.05万
  • 财政年份:
    2020
  • 负责人:
    Andres Vazquez-Torres
  • 依托单位:
Analysis of regulatory networks in Salmonella pathogenesis.
  • 批准号:
    10678919
  • 项目类别:
  • 资助金额:
    $49.05万
  • 财政年份:
    2020
  • 负责人:
    Andres Vazquez-Torres
  • 依托单位:
国内基金
海外基金
新型F-18标记香豆素衍生物PET探针的研制及靶向Alzheimer's Disease 斑块显像研究
  • 批准号:
    81000622
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2010
  • 负责人:
    梁胜
  • 依托单位:
阿尔茨海默病(Alzheimer's disease,AD)动物模型构建的分子机理研究
  • 批准号:
    31060293
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    26.0万元
  • 批准年份:
    2010
  • 负责人:
    郭亚芬
  • 依托单位:
跨膜转运蛋白21(TMP21)对引起阿尔茨海默病(Alzheimer'S Disease)的γ分泌酶的作用研究