BLRD Research Career Scientist Award Application

BLRD 研究职业科学家奖申请

• 批准号: 10337048
• 负责人: Niketa A. Patel
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337048
• 关键词: Academia; Adipose tissue; Affect; Afghanistan; Alternative Splicing; American soldier; Award; Biochemistry; Biology; Brain Injuries; Cardiovascular Diseases; Career Choice; Caring; Cells; Chemicals; Chronic; Chronic Disease; Clinical; Code; Collaborations; Core Facility; Country; Development; Disease; Doctor of Philosophy; Educational process of instructing; Endocrine Glands; Expenditure; Florida; Functional disorder; Funding; General Population; Goals; Grant; Guidelines; Healthcare; Human; IACUC; In Vitro; International; Iraq; Journals; Laboratories; Leadership; Legal patent; Malignant Neoplasms; Medical; Medical Students; Mentors; Metabolic Diseases; Metabolic syndrome; Metabolism; Mission; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Physiology; Primary Health Care; Publications; Publishing; Quality of life; RNA; Reporting; Research; Research Peer Review; Research Support; Review Committee; Rights; Risk; Rodent; Role; Scientist; Services; Signal Transduction; System; TBI treatment; Therapeutic; Translational Research; Traumatic Brain Injury; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Untranslated RNA; Veterans; Veterans Hospitals; Vietnam; Work; beneficiary; career; career development; combat readiness; comorbidity; cost; economic cost; exosome; graduate student; human tissue; in vivo; inhibitor; meetings; neuroinflammation; news; novel; novel therapeutics; programs; regenerative approach; research and development; stem cell niche; stem cells; symposium; technology development; tissue stem cells; transcriptome sequencing; transcriptomics; trend; undergraduate student

This application is for Research Career Scientist award for Niketa A. Patel, Ph.D., 8/8th VA, PI of active VAMR award, national peer-reviewed research support since 2005, office (Room 303-4) and laboratory (Suites 300 and 303) in James A. Haley Veterans’ Hospital Research Service space. I have developed and established a strong program in cellular and molecular mechanisms of metabolic diseases. My research integrates human studies (translational relevance to human physiology/pathophysiology), in vitro cell studies (for mechanistic studies of alternative splicing and role of noncoding RNA; elucidation of cause vs. effect), in vivo rodent studies (for determining whole body systemic impact of novel inhibitors and stabilizers) and cutting-edge transcriptomics (such as RNAseq global analysis of coding and noncoding RNA and cellular signaling). I have successfully carved a niche in integrating RNA biology with signaling in biologically relevant systems and understanding how it may be a cause or consequence of a disease. Overall, my projects focus on the role of adipose as an endocrine organ and impact of its secretome on the metabolic processes in the body. My research was pivotal to demonstrate that the adipose stem cells’ niche is altered in obesity. 61-83% of DoD beneficiaries and 78% of VA beneficiaries are over-weight or obese, a significantly higher percent compared to general population (VA/DoD Clinical guideline, 2014). With over 9.2 million beneficiaries, the cost of obesity and its related diseases exceeds $1.7 billion annually for the VA while total US expenditures has risen to $254 billion annually. An important application of my research is development of exosomes derived from human adipose stem cells as treatment for traumatic brain injury (TBI) related sequelae. TBI significantly affects the quality of life of veterans and military readiness of our country. A significantly higher percent (22%) of US soldiers and veterans who served in Iraq and Afghanistan (OEF/OIF) have brain injuries compared to those from Vietnam era (12%). The VA projects the 10-year (2016–2025) economic costs of TBI to be $2.2 billion with $0.5 billion for OEF/OIF veterans (CRS report on TBI, 2015). The exosomes from human adipose- derived stem cells provide a novel, cell-free regenerative approach for treatment of chronic effects of TBI. My lab’s recent publications (Sparks et al, Journal of Biological Chemistry 2019; Shi et al, Cell Chemical Biology, 2019; Patel et al, Journal of Neuroinflammation 2018) showcasing extensive work with cutting edge technologies and development of new therapeutics has received immense national and international recognition. These publications follow my career’s trend of publishing translationally relevant, mechanistically strong research in high-impact journals. I hold five USPTO patents with VA asserted rights which were developed as part of my VA duties as a scientist. I have been an invited speaker at national and international scientific meetings. I serve my local VA by serving on IACUC, SRS and R&D committees since 2007 and as Director of JAHVH molecular core facility. At SRS, I have served as vice-chair (2012-14) and Chair (2015-2019). I serve at the national level in the VA Career Development review committee, VA ENDA Merit review Committee and NIH CADO committees. At my affiliate University of South Florida, I teach in the graduate and medical courses since 2002. I have mentored undergraduate, graduate and medical students who have established successful careers. Over the years, I have collaborated with VA and non-VA, clinicians and scientists which has resulted in publications and national grants. Overall, I have contributed significantly to JAHVH research mission of conducting cutting-edge translational research to boost healthcare of Veterans and contributing to the long-term research goals of VAMC.

此应用程序是研究职业科学家奖Niketa A。帕特尔博士，8/8 th VA，活性PI VAMR奖，自2005年以来的国家同行评审研究支持，办公室（303-4室）和 实验室（套房300和303）在詹姆斯A。海莉退伍军人医院研究服务空间。我有 开发并建立了代谢的细胞和分子机制的强大程序 疾病我的研究整合了人类研究（人类翻译相关性） 生理学/病理生理学）、体外细胞研究（用于可变剪接的机制研究， 非编码RNA的作用;因果关系的阐明），体内啮齿动物研究（用于确定整个 新的抑制剂和稳定剂的身体系统影响）和尖端转录组学（如 RNAseq编码和非编码RNA和细胞信号传导的全局分析）。我已经成功 在整合RNA生物学与生物相关系统中的信号传导方面开辟了一个利基市场， 了解它如何成为疾病的原因或后果。总的来说，我的项目集中在 脂肪作为内分泌器官的作用及其分泌组对代谢过程的影响 身体我的研究是证明脂肪干细胞的生态位在肥胖中改变的关键。 61-83%的国防部受益人和78%的VA受益人超重或肥胖， 与一般人群相比，百分比更高（VA/DoD临床指南，2014）。超过9.2 2000万受益者，肥胖及其相关疾病的成本每年超过17亿美元， 而美国的总支出已上升到每年2540亿美元。我的一个重要应用 研究是开发来自人类脂肪干细胞的外泌体作为治疗 创伤性脑损伤（TBI）相关后遗症。TBI显著影响退伍军人的生活质量 我们国家的军事准备。美国士兵和退伍军人的比例明显较高（22%） 与来自越南的人相比，在伊拉克和阿富汗服役的人（OEF/OIF） 时代（12%）。VA预计TBI的10年（2016-2025）经济成本为22亿美元， 5亿美元用于OEF/OIF退伍军人（CRS关于TBI的报告，2015年）。从人类脂肪中提取的外泌体- 衍生的干细胞提供了一种新的、无细胞的再生方法，用于治疗 创伤性脑损伤我的实验室最近的出版物（Sparks et al，Journal of Biological Chemistry 2019; Shi et al，Cell Chemical Biology，2019; Patel et al，Journal of Neuroinflammation 2018）展示了广泛的工作 随着尖端技术和新疗法的发展， 和国际认可。这些出版物遵循了我职业生涯的趋势， 在高影响力的期刊上发表相关的、机械性强的研究。我持有五个美国专利商标局专利与弗吉尼亚州 作为一名科学家，我在退伍军人事务部的职责范围内行使了这些权利。我被邀请了 在国家和国际科学会议上发言。我在IACUC服务， 自2007年起担任SRS和R&D委员会成员，并担任JAHVH分子核心设施主任。在SRS，我 曾担任副主席（2012-14年）和主席（2015-2019年）。我在退伍军人事务部为国家级单位服务 职业发展审查委员会、VA ENDA Merit审查委员会和NIH CADO 委员会。在我的附属南佛罗里达大学，我教授研究生和医学课程 自2002年以来我指导过本科生、研究生和医科学生， 成功的职业生涯。多年来，我与VA和非VA，临床医生和科学家合作 这导致了出版物和国家赠款。总的来说，我对 JAHVH研究的使命是进行尖端的转化研究，以促进医疗保健， 退伍军人和贡献的VAMC的长期研究目标。