Impact of Airborne Heavy Metals on Lung Disease and the Environment

空气中重金属对肺部疾病和环境的影响

• 批准号: 10337080
• 负责人: Veena B. Antony
• 金额: $ 127.21万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337080
• 关键词: 3-Dimensional; Address; Affect; African American; Air; Air Pollution; Alabama; Amendment; Area; Arsenic; Arts; Asthma; Biological; Biological Markers; Blood; Bronchoalveolar Lavage Fluid; Cadmium; Childhood Asthma; Chronic; Chronic Obstructive Pulmonary Disease; Chronic lung disease; Civil Rights; Coke; Communication; Communities; County; Data; Detection; Developed Countries; Development; Disease; Engineering; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Environmental Medicine; Environmental Science; Epidemiology; Excision; Exhalation; Exposure to; Fostering; Goals; Health; Heart; Heavy Metals; Home; Human; Hybrids; Incidence; Industrialization; Industry; Inhalation; Knowledge; Lead; Link; Low income; Lower Respiratory Tract Infection; Lung; Lung diseases; Manganese; Measures; Metal exposure; Methodology; Methods; Mission; Modality; Molecular; National Institute of Environmental Health Sciences; Non-Invasive Cancer Detection; Nose; Optics; Organoids; Pathogenesis; Patients; Persons; Phenotype; Poison; Pollution; Population; Post-Translational Protein Processing; Predisposition; Prevalence; Process; Public Health Schools; Research; Resources; Respiratory System; Risk; Risk Factors; Role; Schools; Science; Scientist; Services; Signal Recognition Particle; Site; Smoking; Socioeconomic Status; Soil; Specimen; Steel; Study Subject; Superfund; Surface; System; Technology; Tennessee; Toxic Environmental Substances; Toxicology; Training Programs; Translational Research; United States; United States Environmental Protection Agency; Universities; Work; aerosolized; base; biobank; biomarker validation; chronic respiratory disease; cigarette smoke; coal-fired power plant; college; community engagement; community partnership; cost effective; demographics; disease phenotype; disease registry; human subject; improved; innovation; lung health; lung injury; medical schools; mortality; multidisciplinary; nano; next generation; novel; personalized predictions; programs; remediation; respiratory health; response; superfund site; synergism; tool; toxicant

The University of Alabama at Birmingham (UAB) Superfund Research Program (UAB-SRP) will address environmental airborne pollution with heavy metals, and its impact on respiratory health and environmental degradation. The 35th Avenue, North Birmingham superfund site has been proposed by the EPA to be put on the national priorities list. It is located in the heart of downtown Birmingham, Alabama. The Contaminants of Potential Concern, identified by the EPA include cadmium, arsenic and manganese which will be studied in the UAB-SRP. The site is home to nearly 20,000 people and is in close proximity to coke furnaces, steel mills and other industry. The population is predominantly African American; who recall their recent civil rights struggles in Birmingham, AL and request environmental equity as well as answers to their concerns about their respiratory health. The prevalence of chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Asthma in children and Lower Respiratory Tract Infections (LRTI) is significantly higher in the Affected Area compared to the neighboring Control Area irrespective of smoking, socioeconomic status or demographics. The EPA is in the process of remediating the area, removing soil form several homes since they are recognized to have high arsenic levels. The UAB SRP consists of three biomedical projects and two environmental/ engineering projects that will focus on both human lung health and the health of the environment. All biomedical projects involve direct study of subjects from the Affected Area with a focus on COPD, Asthma and LRTI. The environmental projects include the development and use of an “optical nose” to measure toxicants in the field. Remediation by the use of Nano-Micro hybrid fibrous material for contaminant removal will be studied. Transparent, bidirectional communication with the community is fostered through the community engagement and Administrative/Research Translation cores. This innovative, problem based, solution oriented UAB-SRP will provide a deeper understanding of the health of the environment and directly impact the lung health of the residents of Birmingham, Alabama.

阿拉巴马大学伯明翰分校 (UAB) 超级基金研究计划 (UAB-SRP) 将解决 环境空气中的重金属污染及其对呼吸系统健康和环境的影响 降解。 EPA 提议将北伯明翰第 35 大道超级基金场地投入使用 国家优先事项清单。它位于阿拉巴马州伯明翰市中心。的污染物 EPA 确定的潜在问题包括镉、砷和锰，将在 UAB-SRP。该地点居住着近 20,000 人，紧邻焦炉、钢厂和 其他行业。人口主要是非裔美国人；他们回忆起他们最近在 阿拉巴马州伯明翰市要求环境公平并解答他们对呼吸系统的担忧 健康。慢性阻塞性肺病（COPD）等慢性肺部疾病的患病率， 受影响地区的儿童哮喘和下呼吸道感染 (LRTI) 明显较高 与邻近控制区相比，无论吸烟情况、社会经济地位或人口统计情况如何。这 环保局正在对该地区进行修复，清除几处房屋的土壤，因为人们认为这些房屋 砷含量较高。 UAB SRP 包括三个生物医学项目和两个环境/ 工程项目将重点关注人类肺部健康和环境健康。所有生物医学 项目涉及对受影响地区受试者的直接研究，重点是慢性阻塞性肺病、哮喘和 LRTI。这 环境项目包括开发和使用“光学鼻子”来测量现场有毒物质。 将研究使用纳米-微米混合纤维材料去除污染物的修复方法。 通过社区参与促进与社区的透明、双向沟通 和行政/研究翻译核心。这种创新的、以问题为基础、以解决方案为导向的 UAB-SRP 将 提供对环境健康的更深入了解，并直接影响人们的肺部健康 阿拉巴马州伯明翰的居民。