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Measurement and manipulation of oscillatory biomarker of working memory in psychosis

精神病工作记忆振荡生物标志物的测量和操作

基本信息

批准号：
10337058
负责人：
Molly Erickson
金额：
$ 55.88万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-05 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337058
关键词：
Address Attention Award Biological Markers Brain Chronic Clinical Cognitive Cognitive deficits Coupling Cues Data Development Effectiveness of Interventions Electroencephalography Etiology Event Exhibits Frequencies Future Goals Illness impact Impaired cognition Impairment Individual Intervention Learning Link Literature Maintenance Measurement Measures Memory Memory impairment National Institute of Mental Health Participant Perception Performance Persons Phase Play Population Process Protocols documentation Psychophysiology Psychoses Psychotic Disorders Research Personnel Role Series Short-Term Memory Signal Transduction Specificity Training Validation Variant Visual Work candidate marker clinical biomarkers cognitive ability design effective intervention first episode psychosis functional disability improved memory consolidation memory process memory retention neurobiological mechanism neurofeedback novel peer personalized intervention psychotic symptoms relating to nervous system response severe mental illness therapy development

项目摘要

Project Summary Although it is widely known that people with psychosis (PSY) exhibit impairment in a number of cognitive domains—and working memory (WM) in particular—interventions aimed at remediating these deficits have been only modestly successful, and mixed results continue to emerge. One critical barrier to increasing the effectiveness of these interventions is the lack of clarity regarding neurobiological mechanisms that give rise to these impairments, and that can be used as treatment targets for intervention development. We suggest that one reason for this lack of clarity is that WM is frequently studied as a unitary phenomenon, when in fact it is dependent upon several cognitive sub-processes—each of which is supported by a unique neural process, and any one or any set of which may be impaired in PSY. In the present proposal, we will evaluate the role that a promising oscillatory candidate biomarker (alpha desynchronization) plays in constraining WM capacity in PSY. Then, using neurofeedback, we will train participants to modulate this signal and evaluate the impact of this training on visual WM retention. Recently, we and others have demonstrated that robust task-related alpha desynchronization is associated with higher memory capacity among healthy control subjects during a WM task. Furthermore, PSY exhibit robust impairments in this oscillatory process, indicating that it is a strong candidate mechanism by which WM capacity is constrained in this population. However, because a typical WM task is unable to distinguish between the various cognitive sub-processes that support WM, it is not yet known which of these sub- processes is linked to impaired alpha desynchronization in PSY. In the proposed study, we aim to identify the disrupted sub-process that is reflected in impaired alpha desynchronization in PSY (Aim 1), and further evaluate the causal relationship between this brain process and WM storage by manipulating alpha synchronization using neurofeedback (Aim 3). Additionally, we will determine the extent to which impaired alpha desynchronization is specific to psychotic illness, and the degree to which it is impacted by illness chronicity (Aim 2). Finally, in an Exploratory Aim 4, we will also measure a secondary oscillatory biomarker, theta-gamma phase amplitude coupling, which has previously been linked to the maintenance of a memory trace during the delay interval of a WM task. Our overall goal is to clarify the mechanistic role that alpha desynchronization plays in constraining WM capacity in PSY and its impact on downstream neural processes (i.e., theta-gamma phase amplitude coupling), which will lay the groundwork for future development of precision interventions that may effectively target these processes to yield improvements in WM among PSY.

项目总结