Neuroimaging and Neuromodulation Core

项目摘要 科布雷神经调节中心提出的研究项目涉及广泛的 一系列神经成像和神经调节方法，通常涉及临床参与者 或者那些有神经精神病态的人。神经成像方法包括任务状态和休息状态 MRI，刺激方法包括单次脉冲和重复经颅磁力 刺激或经颅直接刺激。从本质上讲，这些技术是高度 复杂，需要大量的技术掌握才能成功地在临床上部署 人口。这个问题对于相对初级的调查人员或那些 对这些领域来说是个新手。这个Cobre神经成像和神经调节核心的功能 (NNC)将向Cobre提供持续的专家支持、培训、援助和建议 项目负责人在广泛的实施、数据收集和实践方面 与这些方法相关的管理。因此，全国委员会的具体目标是：(1) 为COBRE项目负责人(PLS)提供支持、培训和协助，以促进和 促进获取高质量的神经成像数据；(2)提供支持、培训 并协助COBRE PERS促进高品质的应用 神经调节；以及(3)建立核心资源，并以自我为轨迹 将为更大的神经调节研究服务的持续和持久的地位 罗德岛的社区。为了实现这些目标，科布雷中心的NNC将提供 高度专业化的专业知识、实践培训、教育论坛和在许多方面的帮助 实现目标所需的协议执行、数据获取和资源方面 在每个Cobre项目和神经调节研究人员的独特需求。它将提供 所需的关键实验室空间、设备、基础设施和医疗监督 研究人员正在处理临床样本。通过实现这些目标，全国委员会将(A)加快 高质量的面向机制的COBRE研究的步伐；(B)促进使用安全和 科学严谨的刺激方案；(3)确保高可获得性和可及性 随着时间的推移，科布雷调查人员和更广泛的罗德岛地区的高质量研究基础设施 研究社区。

Project Summary The research projects proposed in the COBRE Center for Neuromodulation involve a broad range of neuroimaging and neuromodulatory methods, and often involving clinical participants or those with neuropsychiatric pathology. Neuroimaging methods include task- and resting state MRI, and stimulation methods include single pulse and repetitive transcranial magnetic stimulation or transcranial direct stimulation. These techniques are, by their nature, highly complex and require significant technical mastery to successful deploy them in clinical populations. This problem is significantly prominent for relatively junior investigators or those new to these fields. The function of this COBRE Neuroimaging and Neuromodulation Core (NNC) is to provide ongoing expert support, training, assistance and advice to the COBRE project leaders in the wide-range of practical aspects of implementation, data collection, and management related to these methods. Therefore, the Specific Aims of the NNC are to (1) provide support, training and assistance to COBRE Project Leaders (PLs) to promote and facilitate the acquisition of high quality neuroimaging data; (2) provide support, training and assistance to COBRE PLs to facilitate the application of high quality neuromodulation; and (3) to establish core resources with a trajectory toward self- sustaining and enduring status that will serve the larger neuromodulation research community in Rhode Island. To meet these aims, the NNC of this COBRE Center will provide highly specialized expertise, hands-on training, educational forums, and assistance in numerous aspects of protocol implementation, data acquisition and resources as required to meet the aims in each COBRE project and the unique needs of neuromodulation investigators. It will offer critical laboratory space, equipment, infrastructure, and medical supervision needed by investigators working with clinical samples. By meeting these goals, the NNC will (a) accelerate the pace of high-quality mechanism-oriented COBRE research; (b) facilitate the use of safe and scientifically rigorous stimulation protocols; (3) ensure the availability and accessibility of high quality research infrastructure over time for COBRE investigators and the broader Rhode Island research community.