Neuroimaging and Neuromodulation Core

项目摘要 COBRE神经调节中心提出的研究项目涉及广泛的 一系列神经成像和神经调节方法，通常涉及临床参与者 或患有神经精神病的人。神经成像方法包括任务状态和静息状态 MRI和刺激方法包括单脉冲和重复经颅磁共振成像。 刺激或经颅直接刺激。这些技术就其本质而言，具有高度的 复杂，需要大量的技术掌握，以成功地将其部署在临床 人口。对于相对初级的调查人员或那些 新到这些领域。此COBRE神经成像和神经调节核心的功能 (NNC)为COBRE提供持续的专家支持、培训、援助和建议 项目负责人在实施，数据收集， 与这些方法有关的管理。因此，NNC的具体目标是（1） 为COBRE项目负责人（PL）提供支持、培训和援助， 促进高质量神经影像学数据的采集;（2）提供支持、培训 并协助COBRE PL，以促进高质量 神经调节;（3）建立核心资源，并朝着自我调节的方向发展。 持续和持久的地位，将服务于更大的神经调节研究 罗得岛的一个社区。为了实现这些目标，COBRE中心的NNC将提供 高度专业化的专业知识，实践培训，教育论坛，并在许多方面提供援助， 议定书的执行、数据采集和实现目标所需的资源 在每个COBRE项目和神经调节研究者的独特需求。它将提供 关键的实验室空间，设备，基础设施和医疗监督所需的 研究人员正在研究临床样本。通过实现这些目标，NNC将（a）加速 （B）促进安全和可靠的COBRE技术的使用， 科学严谨的刺激方案;（3）确保高可用性和可获得性 随着时间的推移，COBRE调查人员和更广泛的罗得岛的质量研究基础设施 研究社区。

Project Summary The research projects proposed in the COBRE Center for Neuromodulation involve a broad range of neuroimaging and neuromodulatory methods, and often involving clinical participants or those with neuropsychiatric pathology. Neuroimaging methods include task- and resting state MRI, and stimulation methods include single pulse and repetitive transcranial magnetic stimulation or transcranial direct stimulation. These techniques are, by their nature, highly complex and require significant technical mastery to successful deploy them in clinical populations. This problem is significantly prominent for relatively junior investigators or those new to these fields. The function of this COBRE Neuroimaging and Neuromodulation Core (NNC) is to provide ongoing expert support, training, assistance and advice to the COBRE project leaders in the wide-range of practical aspects of implementation, data collection, and management related to these methods. Therefore, the Specific Aims of the NNC are to (1) provide support, training and assistance to COBRE Project Leaders (PLs) to promote and facilitate the acquisition of high quality neuroimaging data; (2) provide support, training and assistance to COBRE PLs to facilitate the application of high quality neuromodulation; and (3) to establish core resources with a trajectory toward self- sustaining and enduring status that will serve the larger neuromodulation research community in Rhode Island. To meet these aims, the NNC of this COBRE Center will provide highly specialized expertise, hands-on training, educational forums, and assistance in numerous aspects of protocol implementation, data acquisition and resources as required to meet the aims in each COBRE project and the unique needs of neuromodulation investigators. It will offer critical laboratory space, equipment, infrastructure, and medical supervision needed by investigators working with clinical samples. By meeting these goals, the NNC will (a) accelerate the pace of high-quality mechanism-oriented COBRE research; (b) facilitate the use of safe and scientifically rigorous stimulation protocols; (3) ensure the availability and accessibility of high quality research infrastructure over time for COBRE investigators and the broader Rhode Island research community.