Dissecting Sensorimotor Pathways Underlying Social Interactions: Models, Circuits, and Behavior

剖析社会互动背后的感觉运动通路：模型、回路和行为

• 批准号: 10338085
• 负责人: WILLIAM BIALEK
• 金额: $ 37.98万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10338085
• 关键词: Animal Behavior; Animal Model; Animals; Auditory; Back; Behavior; Behavioral; Behavioral Assay; Behavioral Mechanisms; Biophysics; Brain; Cognitive; Collaborations; Complex; Computer Models; Courtship; Cues; Data; Disease; Drosophila genus; Drosophila melanogaster; Elements; Feedback; Female; Generations; Genetic; Human; Image; Impairment; Individual; Insecta; Joints; Light; Link; Maps; Measures; Methods; Modality; Modeling; Monitor; Motor Pathways; Motor output; Nervous system structure; Neural Pathways; Neurons; Neurosciences; Output; Parkinson Disease; Partner Communications; Pathway interactions; Perception; Personal Satisfaction; Postdoctoral Fellow; Posture; Process; Production; Public Health; Recording of previous events; Research; Research Personnel; Resolution; Ritual compulsion; Rodent; Sensory; Signal Transduction; Social Behavior; Social Interaction; Stimulus; System; Testing; Time; Visual; Work; autism spectrum disorder; behavior measurement; cell type; court; design; experience; experimental study; fictional works; fly; graduate student; male; motor behavior; neural circuit; neural model; neuromechanism; neuronal circuitry; neuroregulation; optogenetics; predictive modeling; prevent; relating to nervous system; response; sensory feedback; sensory input; sensory integration; sensory stimulus; social; theories; tool; treadmill; virtual reality

Project Summary/Abstract Social interactions across the animal kingdom, from courtship rituals and aggressive interactions to spoken conversation, are wondrously complex - they necessarily involve back- and-forth feedback between nervous systems transmitted through multiple sensory modalities and each animal's behavior. Typical experiments in this field observe only a tiny fraction of the activity in any neuronal circuit, and then only under a very limited range of behavioral conditions. To overcome this limitation, the proposed research leverages the compact nervous system of Drosophila melanogaster, combined with its wealth of genetic tools, to study the dynamic behavioral interactions and detailed neural mechanisms that underlie courtship between males and females. The project combines unbiased measurement of behavior, neural circuit manipulations, neural recordings in behaving animals, and sophisticated computational models. The specific aims include: i) elucidating the computations that the brain performs during courtship by mapping the sensorimotor transformations underlying male and female interactions over time via quantitative behavioral assays and the generation of predictive models; ii) combining models with neural perturbations to map the underlying circuits that govern the link between sensory inputs and behaviors; And, iii) testing the models of neural control during courtship by monitoring neural activity in behaving animals experiencing fictive courtship stimuli in a virtual-reality apparatus. This work will substantially advance our understanding of how two interacting brains process and transfer information, and will uncover general principles of neural circuit function that will inform studies of sensorimotor integration in more complex animals, such as rodents and humans. The project will also produce new experimental and theoretical tools for studying social behaviors. Finally, it will shed light on the mechanisms that go awry in several disorders, including Autism Spectrum Disorder (ASD), in which sensory perception becomes disentangled from motor outputs – these disorders have profound effects on cognitive well-being and a major impact on public health.

项目总结/摘要 整个动物王国的社会互动，从求偶仪式和侵略性 从互动到口语对话，是非常复杂的--它们必然涉及到后面的-- 通过多种感觉方式传递的神经系统之间的来回反馈 以及每种动物的行为。这一领域的典型实验只能观察到 任何神经元回路中的活动，并且仅在非常有限的行为条件下进行。 为了克服这一限制，拟议的研究利用了紧凑的神经系统， 果蝇，结合其丰富的遗传工具，研究动态 行为的相互作用和详细的神经机制， 和女性。该项目结合了行为的无偏测量，神经回路， 操纵，行为动物的神经记录，以及复杂的计算模型。 具体目标包括：i）阐明大脑在 通过描绘男女互动背后的感觉运动转换来进行求偶 随着时间的推移，通过定量行为分析和预测模型的生成; ii） 将模型与神经扰动相结合，以映射控制连接的底层电路 感觉输入和行为之间的关系;以及，iii）测试神经控制模型， 通过监测动物在经历虚构的求偶刺激时的神经活动， 在一个虚拟现实设备中。这项工作将大大推进我们对两个 相互作用的大脑处理和传递信息，并将揭示神经网络的一般原理。 电路功能，将为更复杂动物的感觉运动整合研究提供信息， 例如啮齿动物和人类。该项目还将产生新的实验和理论 研究社会行为的工具。最后，它将揭示出差错的机制， 几种疾病，包括自闭症谱系障碍（ASD），其中感官知觉 从运动输出中解脱出来-这些疾病对认知能力有深远的影响。 健康，并对公共卫生产生重大影响。

项目成果

Mice alternate between discrete strategies during perceptual decision-making.

• DOI: 10.1038/s41593-021-01007-z
• 发表时间: 2022-03
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Ashwood ZC;Roy NA;Stone IR;International Brain Laboratory;Urai AE;Churchland AK;Pouget A;Pillow JW
• 通讯作者: Pillow JW

Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making.

• DOI: 10.1038/s41593-020-0696-5
• 发表时间: 2020-11
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Aoi MC;Mante V;Pillow JW
• 通讯作者: Pillow JW

Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.

• DOI: 10.1038/s41467-022-29200-z
• 发表时间: 2022-03-30
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Christensen AJ;Pillow JW
• 通讯作者: Pillow JW

Auditory activity is diverse and widespread throughout the central brain of Drosophila.

• DOI: 10.1038/s41593-020-00743-y
• 发表时间: 2021-01
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Pacheco DA;Thiberge SY;Pnevmatikakis E;Murthy M
• 通讯作者: Murthy M

From connectome to effectome: learning the causal interaction map of the fly brain.

从连接组到效应组：学习果蝇大脑的因果相互作用图。

• DOI: 10.1101/2023.10.31.564922
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Pospisil,DeanA;Aragon,MaxJ;Dorkenwald,Sven;Matsliah,Arie;Sterling,AmyR;Schlegel,Philipp;Yu,Szi-Chieh;McKellar,ClaireE;Costa,Marta;Eichler,Katharina;Jefferis,GregorySXE;Murthy,Mala;Pillow,JonathanW
• 通讯作者: Pillow,JonathanW