In vivo optical coherence elastography of the cornea: mapping shear and tensile moduli
角膜体内光学相干弹性成像:绘制剪切模量和拉伸模量
基本信息
- 批准号:10344917
- 负责人:
- 金额:$ 36.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-30 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeBiomechanicsBody partCaringClinicClinicalClinical DataCollagen FiberCorneaCorneal StromaDataDegenerative DisorderDependenceDevelopmentDevicesDiagnosisDiseaseElementsError SourcesEyeFibrillar CollagenFosteringFrequenciesGlaucomaGoalsHumanInterventionInvestigationKeratoconusLaser In Situ KeratomileusisLeadLongitudinal StudiesMeasurementMeasuresMechanicsMissionModulusMonitorMorphologyNatural regenerationOcular HypertensionOperative Surgical ProceduresOpticsOutcomePathologicPathological DilatationPatientsPhysiologic Intraocular PressurePlayProceduresProcessPropertyPublic HealthReadingResearchResolutionRoleSafetyShapesStructureStudy modelsSurgical FlapsSystemTechnologyTestingTissuesUltrasonic TransducerUnited States National Institutes of HealthVisionVisualVisual Acuitybasebiomechanical testclinically relevantcrosslinkdiagnostic biomarkerelastographyfirst-in-humanhuman studyimprovedin vivoinnovationinstrumentinterestmechanical propertiesnovelpreventpublic health relevanceresponsesafety outcomesscreeningtonometrytoolviscoelasticity
项目摘要
ABSTRACT
The mechanical stability of the cornea supports visual acuity by maintaining corneal curvature, with
important implications for refractive surgery and the management of cornea ectasia. However, clinical
options for mechanical characterization are limited, particularly when compared to well-established tools
for morphological characterization of the cornea. Several commercial and investigational instruments have
highlighted the potential value of corneal biomechanical analysis, but these devices have limited accuracy
and cannot fully characterize the anisotropic, nonlinear, and spatially varying elastic stiffness of the cornea.
The overarching goal of this project is to develop advanced optical coherence elastography (OCE) for
comprehensive characterization of corneal biomechanics. The proposed technology harnesses both
extensional and flexural elastic waves guided along the cornea to measure in-plane tensile (Young’s) and
shear moduli at mm-scale resolution. The first specific aim is to develop an OCE system using non-contact
ultrasound transducers optimized to excite both elastic waves efficiently at high frequencies spanning 4-
10 kHz. The second specific aim is to test this OCE system with healthy subjects and investigate the
dependence of tensile and shear moduli on age and intraocular pressure in vivo. The third specific aim is
to measure tensile and shear moduli in patients diagnosed with keratoconus and to monitor mechanical
changes after corneal crosslinking treatment. The fourth specific aim is to analyze changes in the moduli
as a result of different corneal refractive surgeries. Various ex vivo measurements and finite-element
modeling studies will also be undertaken in order to interpret the clinical data and relate the measured
moduli to the microstructure of the cornea. This project will advance our understanding of corneal
biomechanics in relation to various natural, pathological, and interventional processes and may lead to a
new clinical tool that can improve the diagnosis and treatment of keratoconus, the safety and visual
outcome of refractive surgery, and the accuracy of tonometry.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Seok-Hyun Andy Yun其他文献
Seok-Hyun Andy Yun的其他文献
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{{ truncateString('Seok-Hyun Andy Yun', 18)}}的其他基金
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用于高通量混合分析的多色激光颗粒
- 批准号:
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- 资助金额:
$ 36.92万 - 项目类别:
In vivo high-resolution mapping of the elastic moduli and tensile stress in the human cornea
人体角膜弹性模量和拉应力的体内高分辨率绘图
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- 资助金额:
$ 36.92万 - 项目类别:
In vivo optical coherence elastography of the cornea: mapping shear and tensile moduli
角膜体内光学相干弹性成像:绘制剪切模量和拉伸模量
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