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The neural foundations of regulation in infancy and the role of individual and environmental factors over time

婴儿期调节的神经基础以及个体和环境因素随时间的作用

基本信息

批准号：
10343726
负责人：
Berenice Anaya
金额：
$ 4.33万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10343726
关键词：
Address Adult Affect Affective Age Anxiety Attention Award Behavior Behavioral Brain Child Child Behavior Child Rearing Childhood Code Cognitive Competence Coupled Cross-Sectional Studies Data Development Developmental Course Educational process of instructing Electroencephalogram Emotional Environmental Risk Factor Foundations Frequencies Funding Goals Individual Individual Differences Infant Intervention Laboratories Lead Learning Length Link Literature Maps Maternal Behavior Measures Mentors Methodology Methods Modeling Mother-Child Relations Mothers National Institute of Mental Health Neural Canal Neurocognitive Neurosciences Parent-Child Relations Parents Pathway Analysis Pattern Phase Play Positioning Attribute Postdoctoral Fellow Postpartum Period Prevention Process Protocols documentation Psychopathology Regulation Reporting Research Research Personnel Research Project Grants Resistance Rest Risk Role Socialization System Systems Development Technical Expertise Techniques Temperament Time Training Transact Videotape Visit Work Writing base career cognitive system contextual factors critical period design dynamic system early childhood functional near infrared spectroscopy graph theory infancy infant temperament interest joint attention maternal anxiety maternal risk middle childhood multilevel analysis negative affect neural correlate neural patterning neurodevelopment neuromechanism novel parental role post-doctoral training pre-clinical pre-doctoral primary caregiver programs relating to nervous system resilience response skills social anxiety tenure track therapy design transmission process visual tracking

项目摘要

Project Summary/Abstract The neural mechanisms of regulation support socioemotional competence 63,74 and may operate as resilience factors in the face of developmental risk for psychopathology 13,17. Investigating how these neural mechanisms emerge and change during infancy may identify critical periods of intervention and individual and contextual factors that condition neurodevelopmental trajectories. Three major gaps exist in this literature: 1) Neural correlates of regulation are well established in the adult literature but have not been examined longitudinally during infancy. 2) The effects of temperament risk, parental psychopathology, and parent-child transactions have only been linked to cross-sectional studies of neural activity, rather than to neurodevelopmental trajectories. 3) The neurocognitive mechanisms underlying the socialization of regulation and psychopathology in parent-child transactions are poorly understood. In this proposal, the first two gaps will be addressed by the dissertation project, and a plan is presented to address the third gap with the postdoctoral research. In the F99 phase, four repeated measures of infant electroencephalogram (EEG) from 8 to 24 months postpartum will be used to map infant trajectories of neural markers implicated in regulation during childhood and adulthood. The EEG data will provide two neural correlates: delta-beta synchrony and network connectivity. At each laboratory visit, infant resting-state EEG is collected, and mother-child interactions are videotaped during a 5-minute free-play task. Additionally, primary caregivers report on their child’s temperament and their own anxiety at each wave. These repeated measures design will enable the applicant to address three main questions: 1) How local and global neural mechanisms underlying regulation emerge and change during infancy. 2) How these neural trajectories are influenced by infant negative affect and maternal anxiety. 3) How dyadic patterns of positive affect and responsivity in the mother-infant relationship impact these neural trajectories. In the K00 phase, the applicant will use novel techniques to assess dyadic neural and cognitive activity in mother- child interactions in order to map specific regulation socialization strategies to neural synchrony, joint attention, and risk for anxiety. The current proposal entails an integrated pre- and postdoctoral training plan to prepare the applicant as an independent researcher in developmental neuroscience. There are four overarching training goals: 1) Gain expertise in the study of infant brain development. 2) Learn and apply advanced quantitative methods and dyadic analysis to the study of brain development. 3) Expand dyadic analysis of mother-child interactions to the neural and cognitive systems and. 4) Develop strong scientific writing and teaching skills. These training goals will effectively prepare the applicant to transition from the predoctoral to the postdoctoral training and build a career program that can be taken into an independent, tenure-track position as a developmental neuroscientist.

项目总结/文摘