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The role of the nucleus reuniens in the temporal organization of memory andbehavior

团聚核在记忆和行为的时间组织中的作用

基本信息

批准号：
10343794
负责人：
Timothy Alexander Allen
金额：
$ 36.38万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-10 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10343794
关键词：
Affect Anatomy Attention Deficit Disorder Attention deficit hyperactivity disorder Behavior Behavioral Brain Brain region Cannulas Cells Clozapine Cognitive Communication Complement Data Discrimination Disease Event Foundations Functional disorder Goals Hippocampus (Brain)Impairment Injections Interdisciplinary Study Investigation Knowledge Lead Learning Medial Memory Mental disorders Mission Motor Muscimol Neurobiology Neurons Odors Oxides Pathway interactions Pattern Perception Performance Positioning Attribute Prefrontal Cortex Procedures Process Property Public Health Rattus Research Research Personnel Reuniens Thalamic Nucleus Role Schizophrenia Site System Testing Thalamic Nuclei Thalamic structure Time United States National Institutes of Health Variant Viral Work base designer receptors exclusively activated by designer drugs experimental study improved innovation knowledge base neuromechanism novel strategies relating to nervous system response

项目摘要

PROJECT SUMMARY/ABSTRACT Temporal organization is critical to many perceptual, cognitive, and behavioral functions. These temporal abilities are adversely impacted in several mental health disorders including, but not limited to, schizophrenia and attention-deficit disorder (ADHD). However, the neurobiological underpinnings of the temporal organization of memory and behavior remain poorly understood. Here, we will focus on the nucleus reuniens of the thalamus (RE), an understudied brain region at the nexus of communication between the hippocampus and medial prefrontal cortex. RE is anatomically positioned to profoundly influence interactions between memory and executive systems in the brain. Based on anatomical and theoretical considerations, we hypothesize that RE is essential to, and RE neurons represent, sequences of events and elapsed time. However, nothing is known about the role of RE in time and temporal contexts. In this project, we will directly test the role of RE in time and temporal contexts in memory and behavior. We will use a broad behavioral strategy testing three different fundamental timing tasks: AIM1, memory for sequences of events; AIM2, elapsed-time memory (scale = minutes); and AIM3, interval timing (scale = tens of seconds). One experimental approach will be to test the causal role of RE, and RE circuitry, using muscimol and state-of-the-art virally-delivered inhibitory designer receptors exclusively activated by designer drugs (DREADDs). In another approach, we will record RE neural activity—neurons, ensembles, and local field potentials—using cutting-edge driveable tetrode arrays. Completion of these aims will establish foundational knowledge for understanding the role of the RE in the temporal organization of memory and behavior. Importantly, we will integrate our findings into a unified theoretical framework for RE circuitry within a medial prefrontal cortex-reuniens-hippocampus system. What we learn from these studies will lead to new approaches in the study of temporal dysfunctions that occur in numerous mental health disorders.

项目总结/文摘