The role of the nucleus reuniens in the temporal organization of memory and behavior

团聚核在记忆和行为的时间组织中的作用

• 批准号: 10065783
• 负责人: Timothy Alexander Allen
• 金额: $ 10.7万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-10 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10065783
• 关键词: Affect; Anatomy; Attention Deficit Disorder; Attention deficit hyperactivity disorder; Behavior; Behavioral; Brain; Brain region; Cannulas; Cells; Clozapine; Cognitive; Communication; Complement; Data; Discrimination; Disease; Event; Foundations; Functional disorder; Gap Junctions; Goals; Hippocampus (Brain); Impairment; Injections; Interdisciplinary Study; Investigation; Knowledge; Lead; Learning; Medial; Memory; Mental disorders; Mission; Motor; Muscimol; Neurobiology; Neurons; Odors; Oxides; Pathway interactions; Pattern; Perception; Performance; Positioning Attribute; Prefrontal Cortex; Procedures; Process; Property; Public Health; Rattus; Research; Research Personnel; Reuniens Thalamic Nucleus; Role; Schizophrenia; Site; System; Testing; Thalamic Nuclei; Thalamic structure; Time; United States National Institutes of Health; Variant; Viral; Work; base; designer receptors exclusively activated by designer drugs; experimental study; improved; innovation; knowledge base; neuromechanism; novel strategies; relating to nervous system; response

PROJECT SUMMARY/ABSTRACT Temporal organization is critical to many perceptual, cognitive, and behavioral functions. These temporal abilities are adversely impacted in several mental health disorders including, but not limited to, schizophrenia and attention-deficit disorder (ADHD). However, the neurobiological underpinnings of the temporal organization of memory and behavior remain poorly understood. Here, we will focus on the nucleus reuniens of the thalamus (RE), an understudied brain region at the nexus of communication between the hippocampus and medial prefrontal cortex. RE is anatomically positioned to profoundly influence interactions between memory and executive systems in the brain. Based on anatomical and theoretical considerations, we hypothesize that RE is essential to, and RE neurons represent, sequences of events and elapsed time. However, nothing is known about the role of RE in time and temporal contexts. In this project, we will directly test the role of RE in time and temporal contexts in memory and behavior. We will use a broad behavioral strategy testing three different fundamental timing tasks: AIM1, memory for sequences of events; AIM2, elapsed-time memory (scale = minutes); and AIM3, interval timing (scale = tens of seconds). One experimental approach will be to test the causal role of RE, and RE circuitry, using muscimol and state-of-the-art virally-delivered inhibitory designer receptors exclusively activated by designer drugs (DREADDs). In another approach, we will record RE neural activity—neurons, ensembles, and local field potentials—using cutting-edge driveable tetrode arrays. Completion of these aims will establish foundational knowledge for understanding the role of the RE in the temporal organization of memory and behavior. Importantly, we will integrate our findings into a unified theoretical framework for RE circuitry within a medial prefrontal cortex-reuniens-hippocampus system. What we learn from these studies will lead to new approaches in the study of temporal dysfunctions that occur in numerous mental health disorders.

项目摘要/摘要 时间组织对许多感知、认知和行为功能至关重要。这些时间 包括但不限于精神分裂症在内的几种精神健康障碍都会对能力产生不利影响。 和注意力缺陷障碍(ADHD)。然而，时间组织的神经生物学基础 记忆和行为的关系仍然知之甚少。在这里，我们将集中讨论核团簇。 丘脑(RE)，一个未被研究的大脑区域，位于海马体和 内侧前额叶皮质。RE在解剖学上的定位是深刻影响记忆之间的相互作用 以及大脑中的执行系统。基于解剖学和理论上的考虑，我们假设 RE对于事件和经过的时间序列是必不可少的，并且RE神经元代表着这些序列。然而，没有什么是 了解RE在时间和时间环境中的作用。在这个项目中，我们将直接测试 在记忆和行为中存在时间和时间背景。我们将使用广泛的行为策略测试 三种不同的基本计时任务：AIM1，事件序列记忆；AIM2，流逝时间记忆 (Scale=分钟)；以及AIM3，间隔计时(Scale=数十秒)。一种实验性的方法将是 使用麝香酚和最新的病毒释放的抑制物，测试RE和RE回路的因果作用 设计师受体仅由设计师药物(DREADD)激活。在另一种方法中，我们将记录 RE神经活动-神经元、集合和局部场电位-使用尖端可驱动四极管 数组。完成这些目标将为理解RE在以下方面的作用奠定基础知识 记忆和行为的时间组织。重要的是，我们将把我们的发现整合到一个统一的 内侧前额叶皮质-神经元-海马体系统中RE回路的理论框架。什么 我们从这些研究中学到的将导致在研究发生在 大量的精神健康障碍。