Biopsychosocial predictors of tumor-associated inflammation and progression

肿瘤相关炎症和进展的生物心理社会预测因子

• 批准号: 10343806
• 负责人: Eida Maria Castro
• 金额: $ 44.83万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-25 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10343806
• 关键词: Address; Adverse event; Advisory Committees; Animal Disease Models; Anxiety; Automobile Driving; Basic Science; Behavioral Research; Breast Cancer Patient; Breast Cancer Risk Factor; C-reactive protein; Cancer Patient; Cells; Child Abuse; Chronic; Chronic stress; Clinical; Clinical Research; Collaborations; Complex; Crime; Data; Development; Disease; Disease Progression; Disease model; Domestic Violence; Educational workshop; Event; Exposure to; Faculty; Funding; General Population; Goals; Health Sciences; High Prevalence; Hispanic; Immune; Incidence; Inflammation; Inflammatory; Inflammatory Response; Institution; Knowledge; Latino; Lead; Link; Lymphoid; Mainstreaming; Malignant Neoplasms; Mammary Neoplasms; Maps; Measures; Mediating; Mental Depression; Mission; Myelogenous; National Institute on Minority Health and Health Disparities; Natural Disasters; Not Hispanic or Latino; Phenotype; Physiological; Postdoctoral Fellow; Posttraumatic growth; Pre-Clinical Model; Process; Program Effectiveness; Prospective cohort; Psychosocial Stress; Recording of previous events; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Risk; Risk Factors; Role; Scientist; Series; Social support; Specialized Center; Strategic Planning; Stress; Structure; Sympathetic Nervous System; Testing; Time; Translational Research; Universities; Up-Regulation; Vision; Woman; authority; base; biological adaptation to stress; biopsychosocial; biopsychosocial factor; breast cancer progression; cancer health disparity; career; cytokine; defined contribution; depressive symptoms; design; early life stress; effectiveness evaluation; empowered; ethnic minority population; experience; health disparity; inflammatory marker; interest; malignant breast neoplasm; minority health disparity; mouse model; parent grant; perceived stress; programs; psychosocial; recruit; resilience; response; self-reported anxiety; social; social stressor; systemic inflammatory response; therapy design; translational scientist; tumor; tumor growth; tumor microenvironment; tumor progression

PROJECT SUMMARY The proposed Administrative Structure for the RCMI Program at the Ponce Health Sciences University (PHSU) will utilize the multi-Pl option. Drs. Jose A. Torres-Ruiz and Richard Noel will serve as PIs with a combined time and effort of 50%. Both PIs are well respected academic leaders and have complementary expertise needed for the effective day-to-day management of a complex enterprise as the RCMI Program at PHSU. The proposed PIs will report directly to the office of the Vice President for Research, who in turn reports to the institution's President. Both PIs will be empowered with the necessary authority and institutional support to effectively and efficiently lead the proposed RCMI Program. The Administrative Core will be closely assisted by the Internal Advisory Committee (IAC) and the External Advisory Committee (EAC). During the next funding cycle, the AC will intend to launch an aggressive effort in establishing and nurturing productive partnerships and collaborations with the purpose of; (1) establishing and expanding the number and quality of the research collaborations with RCMI as well as non-RCMI institutions around the nation, and (2) increasing the capacity of the RCMI Program at PHSU to pursue competitive, mainstream, programs in basic, clinical, and translational research with emphasis in health disparities. This section also contemplates a career enhancement opportunity program. During the next five-year funding cycle, we are committed to promote the establishment of a new cadre of translational scientists with an interest in addressing minority health and health disparities issues. The proposed activities, under this component, targets predominantly junior faculty, Post-Doctoral Fellows as well as middle career scientists with an interest in transitioning from basic to translational research. These efforts are consonant with our Institutional Strategic Plan for Research for the next five years (intended to augment the recruitment, retention, and advancement of biomedical researchers) and with the general vision and mission of NIMHD). The proposed goal will be approached by a series of professional development activities including; a seminar series, workshops, short courses, as well as other initiatives. The AC section further presents an Assessment Plan to evaluate the effectiveness of Program to continue building research infrastructure to development of high quality basic, behavioral, clinical, and translational research activities with strong emphasis on minority health and health disparities. An external team will evaluate the progress of the program in fulfilling the mission of the overall program and its core objectives based on the measure of progress toward achieving short-term, medium-term, and long-term goals.

项目摘要 庞塞健康科学大学RCMI计划的拟议管理结构 （PHSU）将使用多PI选项。Jose A.博士托雷斯-鲁伊斯和理查德诺埃尔将担任PI， 综合时间和精力的50%。两位PI都是备受尊敬的学术领袖， 作为RCMI计划的复杂企业的有效日常管理所需的专业知识 在PHSU。拟议的PI将直接向负责研究的副总裁办公室报告， 向该机构的主席报告。两名首席执行官都将被赋予必要的权力， 机构支持，以有效和高效地领导拟议的RCMI计划。行政核心 将得到内部咨询委员会（IAC）和外部咨询委员会的密切协助 （EAC）。在下一个供资周期，咨询委员会将积极努力建立和 培养富有成效的伙伴关系和合作，目的是：（1）建立和扩大 与RCMI以及全国各地的非RCMI机构进行研究合作的数量和质量， 以及（2）提高PHSU RCMI计划的能力，以追求有竞争力的主流计划， 基础、临床和转化研究，重点关注健康差异。本节还考虑了 职业发展机会计划。在下一个五年资助周期，我们致力于促进 建立一个新的翻译科学家骨干队伍，致力于解决少数群体的健康问题， 健康差距问题。在这一构成部分下，拟议的活动主要针对初级教员， 博士后研究员以及有兴趣从基础过渡到 翻译研究这些努力与我们的下一个研究机构战略计划是一致的。 五年（旨在增加生物医学研究人员的招聘，保留和晋升）， 具有NIMHD的总体愿景和使命）。一系列专业人士将努力实现这一目标。 发展活动包括：系列研讨会、讲习班、短期课程以及其他举措。的 AC部分进一步提出了评估计划，以评估继续建设项目的有效性。 研究基础设施，以发展高质量的基础，行为，临床和转化研究 重点关注少数群体健康和健康差距的活动。一个外部小组将评估 该方案在完成总体方案的使命及其核心目标方面的进展情况， 衡量实现短期、中期和长期目标的进展。