Identity influences on psychosocial traits, biologic age, and cardiovascular disease disparities

项目总结/摘要 心血管疾病（CVD）的差异越来越多地归因于不同的社会条件， 不同的社会群体年龄。众所周知，社会经济和心理社会因素会导致慢性压力， 可能增加CVD的风险，但其机制尚不完全清楚。因此，必须确定 介导或缓和社会压力对CVD的影响。老年科学理论重新概念化慢性 疾病作为一个产品的持续功能失调老化，提供额外的途径，了解如何 社会环境是影响健康的内在因素。从这些文献中发现， 衰老的表观遗传方面，如DNA甲基化，这似乎特别反应于心理社会 压力源表观遗传“时钟”，或基于DNA甲基化的实足年龄，健康， 和死亡率可以作为有用的标记，可以提供重要的缺失信息的关系， 社会压力老化和心血管疾病之间的联系此外，心理因素也可能发挥不可分割的作用， 这些途径。自我概念是许多基于身份的心理社会特征的决定因素 与表观遗传变化和心血管疾病有关。这些包括性格特征，如乐观， 负面影响，以及对自我价值和主观社会地位的信念。重要的是，这些因素是 也被认为会影响个人感知和科普压力的方式。在社会心理学 影响压力源评估和压力反应行为的特质，因此自我概念可以作为一种 干预主观身份特征的可行点，这些特征催化过早和功能失调 在社会不利的背景下，老龄化使个体易患心血管疾病。一个老年科学 从这个角度来看，申请人的身份活力病理学（IVP）模型理论上认为，某些自我概念使 通过促进或预防社会压力对健康的影响， 过早衰老拟议的IVP量表（IVPS）旨在测量这些新的身份特征 假设预测与年龄相关的心理社会因素和心血管健康。的具体目标 本研究拟探讨：1）心理社会风险与复原力因素是否可预测生物年龄 通过表观遗传时钟测量，使用杰克逊心脏研究和动脉粥样硬化研究的数据 社区风险队列;以及2）使用初步定性数据制定并最终确定用于以下方面的项目： IVPS R 00阶段的目标包括检查IVPS的心理测量特性，并评估是否 通过IVPS测量的自我概念可预测CVD相关的心理社会特征和生物老化。 最终，这项工作有可能确定解决种族和性别差异的其他目标 在健康老龄化和CVD中，特别是有利地影响与以下相关的表观遗传变化的方式： 健康老龄化

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) disparities are increasingly attributed to the distinct social conditions in which various social groups age. Socioeconomic and psychosocial factors are known to cause chronic stress that may increase risk of CVD, but the mechanisms are not fully clear. It is therefore important to identify factors that mediate or moderate the effects of social stressors on CVD. Geroscientific theory reconceptualizes chronic disease as a product of sustained dysfunctional aging, offering additional avenues for understanding how the social environment is internalized to influence health. Work emerging from this literature has identified epigenetic dimensions of aging such as DNA methylation which appear particularly responsive to psychosocial stressors. Epigenetic “clocks”, or measures of DNA methylation-based predictors of chronological age, health, and mortality may serve as useful markers that can provide important missing information on the relationships between social stressors, aging, and CVD. Furthermore, psychological factors may also play an integral role in these pathways. Self-concept is a determinant of a number of identity-based psychosocial characteristics associated with both epigenetic changes and CVD. These include dispositional traits such as optimism and negative affect, as well as beliefs about self-worth and subjective social status. Importantly, these factors are also known to influence the way individuals perceive and cope with stress. Antecedent to the psychosocial traits which influence stressor appraisal and stress-responsive behavior, self-concept may therefore serve as a viable point of intervening on the subjective identity characteristics which catalyze premature and dysfunctional aging in the context of social disadvantage and predispose individuals to CVD. Incorporating a geroscientific perspective, the applicant’s Identity Vitality-Pathology (IVP) model theorizes that certain self-concepts render individuals particularly vulnerable or resilient to the health effects of social stressors by promoting or preventing premature aging. The proposed IVP scale (IVPS) aims to measure these novel identity characteristics hypothesized to predict aging-related psychosocial factors and cardiovascular health. The specific objectives of the proposed study are to: 1) examine whether psychosocial risk and resilience factors predict biological age as measured by epigenetic clocks using data combined from the Jackson Heart Study and the Atherosclerosis Risk In Communities cohorts; and 2) use preliminary qualitative data to develop and finalize items for use in the IVPS. R00 phase aims include examining the psychometric properties of the IVPS and assessing whether self-concept as measured by the IVPS predicts CVD-related psychosocial traits and biological aging. Ultimately, this work has the potential to identify additional targets for addressing racial and gender disparities in healthy aging and CVD, particularly ways of favorably influencing epigenetic changes associated with healthy aging.