Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with Obesity

项目概要/摘要 候选人：Joseph Watso博士，是德克萨斯大学西南医学院的博士后研究员 运动与环境医学研究所内的中心。Watso博士寻求指导研究培训 与NHLBI K01，以促进实现他的长期职业目标，指导一个额外资助的临床 实验室Watso博士的研究兴趣是研究心血管疾病的预防和治疗 临床人群的策略。职业发展简介：Watso博士的培训目标是：1） 掌握新的技术技能，如"金标准"呼吸功能评估和测量循环 心血管生物标志物; 2）通过会议建立人类肥胖症的独立研究专业知识， 课程和研讨会; 3）通过与导师共同写作补助金提高技术写作技能， UT西南大学的“成功获得R”计划;以及4）通过期刊俱乐部完善专业技能 参与、指导受训人员并在区域/国家科学会议上发言。研究：肥胖 每10个美国成年人中就有4个患有糖尿病，并与高血压和更高的全因死亡率有关。 无论体重减轻与否，有氧运动都能降低动脉血压（BP），改善心脏代谢。 健康然而，近一半的肥胖成年人因为闲暇时间少而不进行有氧运动 可用性和劳力性呼吸困难继发于高胸壁质量相关的吸气肌功能障碍。在 在其他临床人群中，新出现的数据表明，具有时效性的高阻力吸气肌力 运动训练（IMST）可以降低血压，改善呼吸肌功能。因此，我们将确定 8周的每日高阻力IMST可降低血压，改善呼吸肌功能， 在随机、双盲、假对照（即，极低电阻IMST） 在成人肥胖患者中进行的临床试验。环境：Watso博士将参加世界领先的研究 环境，并接受多学科团队的指导。国际公认的人类生理学家 克雷格克兰德尔，博士，已完成四个NHLBI-R01赠款作为主要研究者和指导> 20 博士后研究员进入独立的研究岗位。他非常适合担任瓦措医生的 第一导师专家肺生理学家Tony Babb博士和肺病学家Andrew Tomlinson医学博士， （共同导师）将提供肥胖成人呼吸功能评估培训。IMST专家菲奥娜 Bailey博士（顾问）将提供实施IMST临床试验的培训。血管生理学家Kerrie Moreau博士（顾问）将提供评估循环心血管生物标志物的培训。内分泌 海梅Almandoz，医学博士，（顾问）将提供肥胖生理学和医学培训。生物统计学家琳达 Hynan博士（顾问）将提供生物统计支持和培训。世界著名的心脏病专家和研究所- 主任本莱文，医学博士，（顾问）将确保博士沃索有必要的资源，成功作为一个初级 教员，并将提供与未来的NHLBI R01补助金提交（S）从所得数据的援助。

PROJECT SUMMARY/ABSTRACT CANDIDATE: Joseph Watso, PhD, is a postdoctoral fellow at the University of Texas Southwestern Medical Center within the Institute for Exercise and Environmental Medicine. Dr. Watso seeks mentored research training with an NHLBI K01 to facilitate achieving his long-term career goal of directing an extramurally-funded clinical laboratory. Dr. Watso’s research interest is to examine cardiovascular disease prevention and treatment strategies in clinical populations. CAREER DEVELOPMENT PLAN: Dr. Watso’s training objectives are to: 1) Master new technical skills, such as “gold-standard” respiratory function assessments and measuring circulating cardiovascular biomarkers; 2) Establish independent research expertise in human obesity through meetings, coursework, and workshops; 3) Improve technical writing skills through co-writing grants with his mentors and UT-Southwestern’s ‘Successfully Obtaining an R’ program; and 4) Refine professional skills through journal club participation, mentoring trainees, and presenting at regional/national scientific meetings. RESEARCH: Obesity affects four-in-ten American adults and is associated with hypertension and greater all-cause mortality. Irrespective of weight loss, aerobic exercise reduces arterial blood pressure (BP) and improves cardiometabolic health. However, nearly half of adults with obesity do not perform aerobic exercise because of low leisure time availability and exertional dyspnea secondary to high chest wall mass-related inspiratory muscle dysfunction. In other clinical populations, emerging data demonstrates time-efficient high-resistance inspiratory muscle strength training (IMST) reduces BP and improves respiratory muscle function. Therefore, we will determine whether eight weeks of daily high-resistance IMST reduces BP, improves respiratory muscle function, and concomitantly reduces exertional dyspnea in a randomized, double-blinded, sham-controlled (i.e., very low-resistance IMST) clinical trial among adults with obesity. ENVIRONMENT: Dr. Watso will train in a world-leading research environment and receive mentoring from a multidisciplinary team. Internationally-recognized human physiologist Craig Crandall, PhD, has completed four NHLBI-R01 grants as the principal investigator and mentored >20 postdoctoral fellows into independent research positions. He is exceptionally-suited to serve as Dr. Watso’s primary mentor. Expert pulmonary physiologist Tony Babb, PhD, and pulmonologist Andrew Tomlinson, MD, (co-mentors) will provide training in respiratory function assessments in adults with obesity. IMST expert Fiona Bailey, PhD, (advisor) will provide training in implementing an IMST clinical trial. Vascular physiologist Kerrie Moreau, PhD (advisor) will provide training in assessing circulating cardiovascular biomarkers. Endocrinologist Jaime Almandoz, MD, (advisor) will provide training in obesity physiology and medicine. Biostatistician Linda Hynan, PhD, (advisor) will provide biostatistical support and training. World-renowned cardiologist and institute- director Ben Levine, MD, (advisor) will ensure Dr. Watso has the resources necessary for success as a junior faculty member and will provide assistance with future NHLBI R01 grant submission(s) from the resultant data.