Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with Obesity

项目摘要/摘要 候选人：约瑟夫·沃索，博士，德克萨斯大学西南医学博士后 该中心位于运动与环境医学研究所内。Watso博士寻求有指导的研究培训 拥有NHLBI K01，以帮助实现他长期的职业目标，即指导一家由外部资金资助的临床 实验室。Watso博士的研究兴趣是检查心血管疾病的预防和治疗 临床人群中的策略。职业发展计划：Watso博士的培训目标是：1) 掌握新的技术技能，如“金标准”呼吸功能评估和测量循环 心血管生物标志物；2)通过会议建立对人类肥胖的独立研究专业知识， 课程作业和研讨会；3)通过与导师和 UT-Southwest的成功获得R项目；4)通过期刊俱乐部提高专业技能 参与、指导受训人员，并在区域/国家科学会议上发言。研究：肥胖 影响美国成年人的比例为四分之四，并与高血压和更高的全因死亡率有关。 不管体重是否减轻，有氧运动都能降低动脉血压，改善心脏代谢 健康。然而，近一半的肥胖成年人由于闲暇时间较少而不进行有氧运动 可获得性和继发于高胸壁肿块相关吸气肌功能障碍的呼吸困难。在……里面 其他临床人群，新兴数据显示时间效率高的高阻力吸气肌力 训练(IMST)可降低血压，改善呼吸肌功能。因此，我们将确定是否 每天服用8周的高阻力IMST可降低血压，改善呼吸肌功能，并伴随而来 在随机、双盲、假对照(即极低阻力IMST)中减少劳力性呼吸困难 成人肥胖症的临床试验。环境：Watso博士将接受世界领先的研究培训 环境，并接受多学科团队的指导。国际公认的人类生理学家 克雷格·克兰德尔博士作为首席研究员和导师，完成了四项NHLBI-R01拨款。 博士后研究员进入独立研究岗位。他非常适合担任Watso博士的 主要导师。肺生理学专家Tony Babb博士和肺病学家Andrew Tomlinson医学博士， (共同导师)将为肥胖成年人提供呼吸功能评估方面的培训。IMST专家菲奥娜 贝利博士(顾问)将提供实施IMST临床试验的培训。血管生理学家克里 Moreau博士(顾问)将提供评估循环心血管生物标记物的培训。内分泌学家 Jaime Almandoz医学博士(顾问)将提供肥胖生理学和医学方面的培训。生物统计学家琳达 海南博士(导师)将提供生物统计学支持和培训。世界著名的心脏病专家和研究所- 董事本·莱文，医学博士(顾问)将确保Watso博士拥有作为一名少年成功所需的资源 教师，并将根据结果数据为未来的NHLBIR01拨款提交(S)提供帮助。

PROJECT SUMMARY/ABSTRACT CANDIDATE: Joseph Watso, PhD, is a postdoctoral fellow at the University of Texas Southwestern Medical Center within the Institute for Exercise and Environmental Medicine. Dr. Watso seeks mentored research training with an NHLBI K01 to facilitate achieving his long-term career goal of directing an extramurally-funded clinical laboratory. Dr. Watso’s research interest is to examine cardiovascular disease prevention and treatment strategies in clinical populations. CAREER DEVELOPMENT PLAN: Dr. Watso’s training objectives are to: 1) Master new technical skills, such as “gold-standard” respiratory function assessments and measuring circulating cardiovascular biomarkers; 2) Establish independent research expertise in human obesity through meetings, coursework, and workshops; 3) Improve technical writing skills through co-writing grants with his mentors and UT-Southwestern’s ‘Successfully Obtaining an R’ program; and 4) Refine professional skills through journal club participation, mentoring trainees, and presenting at regional/national scientific meetings. RESEARCH: Obesity affects four-in-ten American adults and is associated with hypertension and greater all-cause mortality. Irrespective of weight loss, aerobic exercise reduces arterial blood pressure (BP) and improves cardiometabolic health. However, nearly half of adults with obesity do not perform aerobic exercise because of low leisure time availability and exertional dyspnea secondary to high chest wall mass-related inspiratory muscle dysfunction. In other clinical populations, emerging data demonstrates time-efficient high-resistance inspiratory muscle strength training (IMST) reduces BP and improves respiratory muscle function. Therefore, we will determine whether eight weeks of daily high-resistance IMST reduces BP, improves respiratory muscle function, and concomitantly reduces exertional dyspnea in a randomized, double-blinded, sham-controlled (i.e., very low-resistance IMST) clinical trial among adults with obesity. ENVIRONMENT: Dr. Watso will train in a world-leading research environment and receive mentoring from a multidisciplinary team. Internationally-recognized human physiologist Craig Crandall, PhD, has completed four NHLBI-R01 grants as the principal investigator and mentored >20 postdoctoral fellows into independent research positions. He is exceptionally-suited to serve as Dr. Watso’s primary mentor. Expert pulmonary physiologist Tony Babb, PhD, and pulmonologist Andrew Tomlinson, MD, (co-mentors) will provide training in respiratory function assessments in adults with obesity. IMST expert Fiona Bailey, PhD, (advisor) will provide training in implementing an IMST clinical trial. Vascular physiologist Kerrie Moreau, PhD (advisor) will provide training in assessing circulating cardiovascular biomarkers. Endocrinologist Jaime Almandoz, MD, (advisor) will provide training in obesity physiology and medicine. Biostatistician Linda Hynan, PhD, (advisor) will provide biostatistical support and training. World-renowned cardiologist and institute- director Ben Levine, MD, (advisor) will ensure Dr. Watso has the resources necessary for success as a junior faculty member and will provide assistance with future NHLBI R01 grant submission(s) from the resultant data.