Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with Obesity

高效的吸气肌力量训练作为降低血压、改善呼吸功能和减少肥胖成人劳力性呼吸困难的新方法

• 批准号: 10651603
• 负责人: Joseph Watso
• 金额: $ 13.9万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651603
• 关键词: Acute; Adherence; Adult; Aerobic Exercise; Affect; American; Attenuated; Biological Markers; Biometry; Blood Pressure; Blood Vessels; Body Weight decreased; Breathing; Cardiovascular Diseases; Cardiovascular system; Chest Wall Mass; Clinical; Clinical Trials; Controlled Clinical Trials; Data; Development Plans; Doctor of Philosophy; Double-Blind Method; Dyspnea; Educational workshop; Elderly; Endocrinologist; Ensure; Environment; Environmental Medicine; Epidemic; Exercise; Exertion; Extramural Activities; Faculty; Fatigue; Functional disorder; Funding; Future; Goals; Grant; Health; Hour; Human; Hypertension; Inhalation; International; Journals; Laboratories; Leisures; Life Style; Lung; Measures; Medical center; Medicine; Mentors; Metabolic; Morbidity - disease rate; Motor; Muscle; Muscle Fatigue; Muscle function; National Heart, Lung, and Blood Institute; Obesity; Obstructive Sleep Apnea; Outcome; Physiological; Physiology; Population; Positioning Attribute; Postdoctoral Fellow; Prevention strategy; Principal Investigator; Public Health; Randomized; Reporting; Research; Research Training; Resistance; Resources; Respiration Disorders; Respiratory Muscles; Respiratory physiology; Risk; Safety; Secondary to; Secure; Technical Expertise; Texas; Time; Training; United States National Institutes of Health; Universities; Work; Work of Breathing; Writing; adult obesity; arm; blood pressure reduction; cardiometabolism; cardiovascular disorder prevention; cardiovascular health; career; career development; clinical training; cost; efficacy evaluation; exercise intensity; exercise training; experience; high risk; improved; interest; meetings; member; mortality; multidisciplinary; muscle strength; novel; novel strategies; pressure; programs; psychosocial; respiratory; response; skills; strength training; success; technical writing; tool; treatment strategy

PROJECT SUMMARY/ABSTRACT CANDIDATE: Joseph Watso, PhD, is a postdoctoral fellow at the University of Texas Southwestern Medical Center within the Institute for Exercise and Environmental Medicine. Dr. Watso seeks mentored research training with an NHLBI K01 to facilitate achieving his long-term career goal of directing an extramurally-funded clinical laboratory. Dr. Watso’s research interest is to examine cardiovascular disease prevention and treatment strategies in clinical populations. CAREER DEVELOPMENT PLAN: Dr. Watso’s training objectives are to: 1) Master new technical skills, such as “gold-standard” respiratory function assessments and measuring circulating cardiovascular biomarkers; 2) Establish independent research expertise in human obesity through meetings, coursework, and workshops; 3) Improve technical writing skills through co-writing grants with his mentors and UT-Southwestern’s ‘Successfully Obtaining an R’ program; and 4) Refine professional skills through journal club participation, mentoring trainees, and presenting at regional/national scientific meetings. RESEARCH: Obesity affects four-in-ten American adults and is associated with hypertension and greater all-cause mortality. Irrespective of weight loss, aerobic exercise reduces arterial blood pressure (BP) and improves cardiometabolic health. However, nearly half of adults with obesity do not perform aerobic exercise because of low leisure time availability and exertional dyspnea secondary to high chest wall mass-related inspiratory muscle dysfunction. In other clinical populations, emerging data demonstrates time-efficient high-resistance inspiratory muscle strength training (IMST) reduces BP and improves respiratory muscle function. Therefore, we will determine whether eight weeks of daily high-resistance IMST reduces BP, improves respiratory muscle function, and concomitantly reduces exertional dyspnea in a randomized, double-blinded, sham-controlled (i.e., very low-resistance IMST) clinical trial among adults with obesity. ENVIRONMENT: Dr. Watso will train in a world-leading research environment and receive mentoring from a multidisciplinary team. Internationally-recognized human physiologist Craig Crandall, PhD, has completed four NHLBI-R01 grants as the principal investigator and mentored >20 postdoctoral fellows into independent research positions. He is exceptionally-suited to serve as Dr. Watso’s primary mentor. Expert pulmonary physiologist Tony Babb, PhD, and pulmonologist Andrew Tomlinson, MD, (co-mentors) will provide training in respiratory function assessments in adults with obesity. IMST expert Fiona Bailey, PhD, (advisor) will provide training in implementing an IMST clinical trial. Vascular physiologist Kerrie Moreau, PhD (advisor) will provide training in assessing circulating cardiovascular biomarkers. Endocrinologist Jaime Almandoz, MD, (advisor) will provide training in obesity physiology and medicine. Biostatistician Linda Hynan, PhD, (advisor) will provide biostatistical support and training. World-renowned cardiologist and institute- director Ben Levine, MD, (advisor) will ensure Dr. Watso has the resources necessary for success as a junior faculty member and will provide assistance with future NHLBI R01 grant submission(s) from the resultant data.

项目总结/文摘

项目成果

Habituation attenuates the sex-specific associations between ischemic pain, blood pressure, and arterial stiffness in young adults.

习惯减弱了年轻人缺血性疼痛、血压和动脉僵硬度之间的性别特异性关联。

• DOI: 10.1152/ajpheart.00567.2022
• 发表时间: 2022
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Lincoln,ZoeR;Blumenburg,WesleyT;Cross,BrettL;Vondrasek,JosephD;Watso,JosephC;Flatt,AndrewA;Linder,Braxton;Robinson,AustinT;Grosicki,GregoryJ
• 通讯作者: Grosicki,GregoryJ