Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with Obesity

高效的吸气肌力量训练作为降低血压、改善呼吸功能和减少肥胖成人劳力性呼吸困难的新方法

• 批准号: 10651603
• 负责人: Joseph Watso
• 金额: $ 13.9万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651603
• 关键词: Acute; Adherence; Adult; Aerobic Exercise; Affect; American; Attenuated; Biological Markers; Biometry; Blood Pressure; Blood Vessels; Body Weight decreased; Breathing; Cardiovascular Diseases; Cardiovascular system; Chest Wall Mass; Clinical; Clinical Trials; Controlled Clinical Trials; Data; Development Plans; Doctor of Philosophy; Double-Blind Method; Dyspnea; Educational workshop; Elderly; Endocrinologist; Ensure; Environment; Environmental Medicine; Epidemic; Exercise; Exertion; Extramural Activities; Faculty; Fatigue; Functional disorder; Funding; Future; Goals; Grant; Health; Hour; Human; Hypertension; Inhalation; International; Journals; Laboratories; Leisures; Life Style; Lung; Measures; Medical center; Medicine; Mentors; Metabolic; Morbidity - disease rate; Motor; Muscle; Muscle Fatigue; Muscle function; National Heart, Lung, and Blood Institute; Obesity; Obstructive Sleep Apnea; Outcome; Physiological; Physiology; Population; Positioning Attribute; Postdoctoral Fellow; Prevention strategy; Principal Investigator; Public Health; Randomized; Reporting; Research; Research Training; Resistance; Resources; Respiration Disorders; Respiratory Muscles; Respiratory physiology; Risk; Safety; Secondary to; Secure; Technical Expertise; Texas; Time; Training; United States National Institutes of Health; Universities; Work; Work of Breathing; Writing; adult obesity; arm; blood pressure reduction; cardiometabolism; cardiovascular disorder prevention; cardiovascular health; career; career development; clinical training; cost; efficacy evaluation; exercise intensity; exercise training; experience; high risk; improved; interest; meetings; member; mortality; multidisciplinary; muscle strength; novel; novel strategies; pressure; programs; psychosocial; respiratory; response; skills; strength training; success; technical writing; tool; treatment strategy

PROJECT SUMMARY/ABSTRACT CANDIDATE: Joseph Watso, PhD, is a postdoctoral fellow at the University of Texas Southwestern Medical Center within the Institute for Exercise and Environmental Medicine. Dr. Watso seeks mentored research training with an NHLBI K01 to facilitate achieving his long-term career goal of directing an extramurally-funded clinical laboratory. Dr. Watso’s research interest is to examine cardiovascular disease prevention and treatment strategies in clinical populations. CAREER DEVELOPMENT PLAN: Dr. Watso’s training objectives are to: 1) Master new technical skills, such as “gold-standard” respiratory function assessments and measuring circulating cardiovascular biomarkers; 2) Establish independent research expertise in human obesity through meetings, coursework, and workshops; 3) Improve technical writing skills through co-writing grants with his mentors and UT-Southwestern’s ‘Successfully Obtaining an R’ program; and 4) Refine professional skills through journal club participation, mentoring trainees, and presenting at regional/national scientific meetings. RESEARCH: Obesity affects four-in-ten American adults and is associated with hypertension and greater all-cause mortality. Irrespective of weight loss, aerobic exercise reduces arterial blood pressure (BP) and improves cardiometabolic health. However, nearly half of adults with obesity do not perform aerobic exercise because of low leisure time availability and exertional dyspnea secondary to high chest wall mass-related inspiratory muscle dysfunction. In other clinical populations, emerging data demonstrates time-efficient high-resistance inspiratory muscle strength training (IMST) reduces BP and improves respiratory muscle function. Therefore, we will determine whether eight weeks of daily high-resistance IMST reduces BP, improves respiratory muscle function, and concomitantly reduces exertional dyspnea in a randomized, double-blinded, sham-controlled (i.e., very low-resistance IMST) clinical trial among adults with obesity. ENVIRONMENT: Dr. Watso will train in a world-leading research environment and receive mentoring from a multidisciplinary team. Internationally-recognized human physiologist Craig Crandall, PhD, has completed four NHLBI-R01 grants as the principal investigator and mentored >20 postdoctoral fellows into independent research positions. He is exceptionally-suited to serve as Dr. Watso’s primary mentor. Expert pulmonary physiologist Tony Babb, PhD, and pulmonologist Andrew Tomlinson, MD, (co-mentors) will provide training in respiratory function assessments in adults with obesity. IMST expert Fiona Bailey, PhD, (advisor) will provide training in implementing an IMST clinical trial. Vascular physiologist Kerrie Moreau, PhD (advisor) will provide training in assessing circulating cardiovascular biomarkers. Endocrinologist Jaime Almandoz, MD, (advisor) will provide training in obesity physiology and medicine. Biostatistician Linda Hynan, PhD, (advisor) will provide biostatistical support and training. World-renowned cardiologist and institute- director Ben Levine, MD, (advisor) will ensure Dr. Watso has the resources necessary for success as a junior faculty member and will provide assistance with future NHLBI R01 grant submission(s) from the resultant data.

项目概要/摘要 候选人：Joseph Watso 博士，德克萨斯大学西南医学院博士后研究员 运动与环境医学研究所内的中心。 Watso 博士寻求指导研究培训 获得 NHLBI K01，以促进实现指导外部资助临床的长期职业目标 实验室。 Watso 博士的研究兴趣是心血管疾病的预防和治疗 临床人群的策略。职业发展计划：Watso 博士的培训目标是：1) 掌握新技术技能，例如“黄金标准”呼吸功能评估和循环测量 心血管生物标志物； 2）通过会议建立人类肥胖的独立研究专业知识， 课程作业和研讨会； 3）通过与导师共同写作资助来提高技术写作技能 UT-Southwestern 的“成功获得 R”计划； 4) 通过期刊俱乐部提高专业技能 参与、指导学员并在区域/国家科学会议上发表演讲。研究：肥胖 影响十分之四的美国成年人，并与高血压和更高的全因死亡率有关。 无论体重如何减轻，有氧运动都能降低动脉血压（BP）并改善心脏代谢 健康。然而，近一半的肥胖成年人由于闲暇时间少而没有进行有氧运动 可用性和继发于高胸壁质量相关的吸气肌功能障碍的劳力性呼吸困难。在 在其他临床人群中，新出现的数据表明高阻力吸气肌力量具有省时效果 训练（IMST）可降低血压并改善呼吸肌功能。因此，我们将确定是否 八周的每日高阻 IMST 可降低血压，改善呼吸肌功能，同时 在随机、双盲、假对照（即极低阻力 IMST）中减少劳力性呼吸困难 肥胖成人的临床试验。环境：Watso 博士将接受世界领先的研究培训 环境并接受多学科团队的指导。国际公认的人体生理学家 Craig Crandall 博士作为首席研究员完成了四项 NHLBI-R01 资助，并指导了超过 20 名 博士后进入独立研究岗位。他非常适合担任 Watso 博士的 主要导师。肺生理学专家 Tony Babb 博士和肺病学家 Andrew Tomlinson 医学博士 （共同导师）将为肥胖成人提供呼吸功能评估培训。 IMST专家菲奥娜 Bailey 博士（顾问）将提供实施 IMST 临床试验的培训。血管生理学家克里 Moreau 博士（顾问）将提供评估循环心血管生物标志物的培训。内分泌科医生 Jaime Almandoz 医学博士（顾问）将提供肥胖生理学和医学方面的培训。生物统计学家琳达 Hynan 博士（顾问）将提供生物统计支持和培训。世界著名心脏病专家和研究所- 主任 Ben Levine 医学博士（顾问）将确保 Watso 博士拥有作为初级人员取得成功所需的资源 教职人员，并将根据结果数据为未来 NHLBI R01 拨款申请提供帮助。

项目成果

Habituation attenuates the sex-specific associations between ischemic pain, blood pressure, and arterial stiffness in young adults.

习惯减弱了年轻人缺血性疼痛、血压和动脉僵硬度之间的性别特异性关联。

• DOI: 10.1152/ajpheart.00567.2022
• 发表时间: 2022
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Lincoln,ZoeR;Blumenburg,WesleyT;Cross,BrettL;Vondrasek,JosephD;Watso,JosephC;Flatt,AndrewA;Linder,Braxton;Robinson,AustinT;Grosicki,GregoryJ
• 通讯作者: Grosicki,GregoryJ