Research Core

摘要 生成、存储和分析高通量基因组数据的能力对于现代 生物学，尤其是人类遗传学。克莱姆森大学基因组学和生物信息学设施 (CUGBF)提供中小型基因组分析和定制的生物信息学服务。这个 克莱姆森大学人类遗传学基因组科学实验室中心(CUCHG-GSL)支持- 房屋高通量、大规模基因组分析，包括第三代单分子长读 测序和单细胞分析，以及基因组数据的定制生物信息学和统计分析。 人类遗传学科布雷将扩大克莱姆森大学基因组学和生物信息学的范围 和南卡罗来纳州通过结合和扩展基因组学、生物信息学和计算 CUGBF和CUCHG-GSL的基础设施和人员在增强的 CUGBF。扩展后的CUGBF将覆盖下一代测序平台的范围，提供 定制生物信息学和统计分析以及关于实验设计的建议，以及基因组学和 生物信息学研讨会和讲习班。因此，增强的CUGBF将提供基础设施、项目 指导、监督和培训，以增强科布雷在人类遗传学研究和试点项目中的能力 领导者及其实验室团队全面部署现有的和新兴的基因组和计算 技术在他们的研究计划中。这些服务也将适用于克莱姆森大学的所有教职员工 以及他们的研究小组以及南卡罗来纳州姐妹机构的教职员工。此外，增强的 CUGBF将每月举办基因组学和生物信息学研讨会和动手研讨会，以培训学生， 博士后研究员和教师在获取和分析基因组数据方面变得自给自足。这个 因此，增强的CUGBF满足了广泛采用现代基因组学和 机构发展奖中的生物信息学研究：(1)基因组学和 计算基础设施；(2)向调查人员提供分子生物学和生物信息学服务 对如此大规模的分析；以及(3)培训研究人员在获取和分析方面自给自足 基因组学数据。

SUMMARY The ability to generate, store and analyze high throughput genomic data is critical for many aspects of modern biology, and especially for human genetics. The Clemson University Genomics and Bioinformatics Facility (CUGBF) provides small to moderate scale genome analysis and customized bioinformatics services. The Clemson University Center for Human Genetics Genome Sciences Laboratories (CUCHG-GSL) supports in- house high throughput, large scale genome analysis, including third generation single molecule long-read sequencing and single cell analyses, as well as custom bioinformatic and statistical analyses of genomic data. The COBRE in Human Genetics will expand the scope of genomics and bioinformatics at Clemson University and the State of South Carolina by combining and expanding the genomics, bioinformatics and computational infrastructure and personnel of the CUGBF and the CUCHG-GSL under the single umbrella of an enhanced CUGBF. The expanded CUGBF will span the spectrum of next generation sequencing platforms, provide custom bioinformatics and statistical analyses and advice on experimental design, and genomics and bioinformatics seminars and workshops. The enhanced CUGBF will thus provide the infrastructure, project guidance and supervision, and training to empower COBRE in Human Genetics Research and Pilot Project Leaders and their laboratory groups to fully deploy extant and emerging genomic and computational technologies in their research programs. These services will also be available for all Clemson University faculty and their research groups as well as faculty in sister institutions in South Carolina. In addition, the enhanced CUGBF will host monthly genomics and bioinformatics seminars and hands-on workshops to train students, postdoctoral fellows and faculty to become self-sufficient in obtaining and analyzing genomics data. The enhanced CUGBF thus fills three critical needs for the wide scale adoption of modern genomics and bioinformatics research in an Institutional Development Award state: (1) local availability of genomics and computational infrastructure; (2) provision of molecular biology and bioinformatics services to investigators new to such large scale analyses; and (3) training researchers to become self-sufficient in obtaining and analyzing genomics data.