Career Enhancement Core

职业提升核心(CEC)将有助于培养下一代科学家和 临床医生--作为女性健康和医学性别差异领域的领导者的科学家。他们将会是 有能力帮助了解主要精神疾病和相关疾病的性别依赖易感性 医学上的障碍。我们的评分侧重于了解严重抑郁症和相关疾病的性别差异 自主神经生理学和将这一知识转化为性别依赖疗法的发展。 除了性别之外，定义性别的影响将使我们的参与者做好准备，思考翻译 科学发现对政策和宣传的影响。培养下一代关于性和性别的重要性 对医学和医疗保健的认识将对实现国家发展战略规划至关重要 精准或个性化的医疗。成绩教员在训练人们思考方面有着悠久的历史。 医学中的性别和性别。我们将整合SCORE合作伙伴的培训基础设施 为妇女健康和性别差异疾病提供新的机遇，拓展资源，增添新的 教员，并就新技术和方法对受训人员进行教育。CEC将利用 在性别差异和妇女健康方面开展跨学科研究合作的传统由来已久 这些机构的调查人员，包括之前关注性别差异的ORWH P50 SCOR 在哈佛大学、密歇根州立大学和亚利桑那大学的严重抑郁症中。我们向我们的学员提供了 跨机构的大量生物医学资源，解决对改进 妇女健康。为了促进成绩学员的职业生涯，CEC将具体：1)整合 关于性别差异和性别差异的基础和临床层面的致病机制的培训和思考 和政策层面的健康差距。2)从团队的角度指导受训人员，使他们接触到 来自具有互补专业知识的导师的不同级别的分析。3)提供访问材料和 教师资源，这将提高第一批候选人的成功。CEC基础设施将 提供一个未来可以推广到其他人的模式，在培训中发挥召集/整合作用 跨领域、跨方法论和跨机构的下一代。我们还致力于培养多元化的 生物医学劳动力，这一得分中包括的第一组参与者和调查人员就是例证。 两名初级教员将根据他们对性的兴趣作为实施这一CEC的初始模式 大脑中免疫途径的差异、胎儿编程和后代大脑发育及其影响 怀孕并发症对后代大脑和心脏功能的影响。最后，我们将(4)提供种子资金 补充临床前研究的工作，并最终转化为人体研究。总而言之，这是 CORE将创建个人定制的课程，利用各个领域的导师优势 并培养下一代妇女健康研究的后起之秀的专业技能。

The Career Enhancement Core (CEC) will contribute to training the next generation of scientists and clinician- scientists as leaders in the fields of women's health and sex differences in medicine. They will be empowered to contribute to understanding sex-dependent vulnerabilities to major psychiatric and associated medical disorders. Our SCORE focuses on understanding sex differences in major depression and associated autonomic physiology and translation of this knowledge into the development of sex-dependent therapeutics. Defining the impact of gender in addition to sex, will prepare our participants to think about translation of scientific findings to policy and advocacy. Training the next generation as to the importance of sex and gender in understanding medicine and healthcare will be critical in realizing the national strategic plan to develop precision or personalized medicine. The SCORE faculty have a long history of training people to think about sex and gender in medicine. We will integrate the training infrastructures of the SCORE partners focused on women's health and sex differences in diseases to provide new opportunities, expand resources, add new faculty, and educate trainees with regard to new technologies and approaches. The CEC will capitalize on a long tradition of interdisciplinary research collaborations on sex differences and women's health among investigators across these institutions, including a previous ORWH P50 SCOR that focused on sex differences in major depression across HMS, CSU, and the University of Arizona. We have made available to our mentees a vast array of biomedical resources across institutions that address scientific questions essential to improving women's health. To enhance the careers of SCORE trainees, the CEC will specifically: 1) Integrate levels of training and thought about etiologic mechanisms at basic and clinical levels for sex differences, and for gender and health disparities at the policy level. 2) Mentor trainees from a team perspective that exposes them to different levels of analysis from mentors with complementary expertise. 3) Provide access to material and faculty resources that will enhance the success of the initial group of candidates. The CEC infrastructure will provide a model that can be generalized to others in the future, playing a convening/integrative role in training the next generation across fields, methodologies and institutions. We are also committed to training a diverse biomedical workforce, as exemplified by the first set of participants and investigators included in this SCORE. Two junior faculty will serve as initial models for implementing this CEC based on their interests in sex differences in immune pathways in the brain, fetal programming and offspring brain development, and impact of pregnancy complications on offspring brain and cardiac function. Finally, we will (4) provide seed funding to supplement work with the preclinical studies and ultimately translate to the human studies. In summary, this core will create individually-tailored curricula that will take advantage of mentorship strengths across institutions and foster the professional skills of a next generation of rising stars for women's health research.