Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience

描述(由申请者提供)：这个以患者为中心的研究生涯中期奖将允许首席研究员扩大他的导师、职业发展和以患者为中心的精神病学遗传学和神经科学的整合研究。首席研究员是精神病学遗传学和临床研究领域的知名临床科学家。这项申请包括三个部分：1)指导计划，旨在加强首席调查员在精神病学遗传学和神经科学方面指导年轻研究人员的能力；2)职业发展计划，旨在扩大首席调查员在遗传学和神经成像方面的专业知识；以及3)研究计划，利用首席调查员对精神疾病的遗传、行为和神经基础及其与大脑结构和功能正常变化的关系的现有研究。首席调查员在指导和培养遗传、临床和流行病学研究领域的受训者和初级教员方面有着良好的记录。这项裁决将为首席调查员提供受保护的时间，以扩大和加强这些努力。指导计划利用他目前的指导活动和众多合作研究项目，为新一代研究人员开发一条职业发展道路，能够在以患者为中心的遗传学和神经科学的界面上整合尖端方法。学员将在以患者为中心的研究中获得实践经验，并将发展自己的独立研究方向。MGH和更广泛的哈佛医学院社区的临床和转化性研究资源将为学员提供丰富的培训环境。该应用程序的新研究部分将包括全基因组大脑表型分析，以检查焦虑症的遗传和神经结构。这项申请旨在满足国家精神卫生研究所促进精神障碍原因研究的战略计划和国家咨询精神卫生委员会研究培训工作组确定的目标，以扩大对能够进行实现这些目标所需的跨学科研究的年轻调查人员的指导。

DESCRIPTION (provided by applicant): This Mid-Career Investigator Award in Patient-Oriented Research will permit the Principal Investigator to expand his mentorship, career development, and research on the integration of patient-oriented psychiatric genetics and neuroscience. The Principal Investigator is an established clinician-scientist in psychiatric genetics and clinical research. This application includes three components: 1) a mentoring plan designed to enhance the Principal Investigator's ability to mentor young investigators in psychiatric genetics and neuroscience; 2) a career development plan designed to expand the Principal Investigator's expertise in the integration of genetics and neuroimaging; and 3) a research plan that leverages the Principal Investigator's existing investigations on the genetic, behavioral and neural basis of psychiatric disorders and their relationship to normal variation in brain structure and function. The Principal Investigator has a substantial track record of mentoring and cultivating trainees and junior faculty in the area of genetic, clinical and epidemiologic research. This award would provide protected time for the Principal Investigator to expand and enhance these efforts. The mentoring plan capitalizes on his current mentoring activities and numerous collaborative research projects to develop a career development path for a new generation of investigators capable of integrating cutting-edge methods at the interface of patient-oriented genetics and neuroscience. Mentees will gain hands-on experience in patient-oriented research and will develop their own independent research directions. The clinical and translational research resources at MGH and the broader Harvard Medical School community will provide a rich training environment for mentees. The new research component of the application will include genomewide analyses of brain phenotypes to examine the genetic and neural architecture of anxiety disorders. This application was designed to address objectives identified by NIMH's Strategic Plan to fuel research on the causes of mental disorders and the National Advisory Mental Health Council Workgroup on Research Training to expand mentoring of young investigators capable of conducting the interdisciplinary research needed to achieve those objectives.