Career Enhancement Core

职业提升核心

• 批准号: 10540786
• 负责人: JORDAN W SMOLLER
• 金额: $ 11.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540786
• 关键词: Address; Advocacy; Arizona; Award; Behavior; Biology; Biomedical Engineering; Brain; Brain Diseases; Center for Translational Science Activities; Clinical; Clinical Research; Clinical Sciences; Collaborations; Colorado; Development; Disease; Early Intervention; Educational Curriculum; Educational Status; Environmental Risk Factor; Etiology; Faculty; Family; Family member; Fostering; Funding; Future; Gender; Genes; Genetic; Genomics; Health; Healthcare; Healthcare Systems; Heart; Home; Hormones; Hospitals; Human; Immune; Individual; Infrastructure; Institution; Interdisciplinary Study; Longevity; Major Depressive Disorder; Massachusetts; Medical; Medicine; Mental disorders; Mentors; Mentorship; Metabolic; Methodology; Methods; Modeling; Moods; Morbidity - disease rate; Outcome; Participant; Pathology; Pathway interactions; Pattern; Persons; Physiology; Play; Policies; Population; Pregnancy Complications; Prevention; Proteomics; Public Health Schools; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Rest; Role; Schools; Science; Scientist; Sex Differences; Site; Strategic Planning; Structure; Supervision; System; Therapeutic; Therapeutic Research; Training; Training and Infrastructure; Translating; Translational Research; Translations; United States National Institutes of Health; Universities; Woman; Women' s Health; Work; attenuation; biomedical resource; career; career development; didactic education; disability; empowerment; experience; fetal programming; gender disparity; health care service utilization; health difference; health disparity; heart function; imaging facilities; improved; insight; interest; knowledge translation; medical schools; metabolomics; multidisciplinary; new technology; next generation; novel strategies; offspring; personalized medicine; pre-clinical research; precision medicine; preclinical study; prenatal stress; programs; research and development; sex; skills; social; steroid hormone; success; translational model

The Career Enhancement Core (CEC) will contribute to training the next generation of scientists and clinician- scientists as leaders in the fields of women's health and sex differences in medicine. They will be empowered to contribute to understanding sex-dependent vulnerabilities to major psychiatric and associated medical disorders. Our SCORE focuses on understanding sex differences in major depression and associated autonomic physiology and translation of this knowledge into the development of sex-dependent therapeutics. Defining the impact of gender in addition to sex, will prepare our participants to think about translation of scientific findings to policy and advocacy. Training the next generation as to the importance of sex and gender in understanding medicine and healthcare will be critical in realizing the national strategic plan to develop precision or personalized medicine. The SCORE faculty have a long history of training people to think about sex and gender in medicine. We will integrate the training infrastructures of the SCORE partners focused on women's health and sex differences in diseases to provide new opportunities, expand resources, add new faculty, and educate trainees with regard to new technologies and approaches. The CEC will capitalize on a long tradition of interdisciplinary research collaborations on sex differences and women's health among investigators across these institutions, including a previous ORWH P50 SCOR that focused on sex differences in major depression across HMS, CSU, and the University of Arizona. We have made available to our mentees a vast array of biomedical resources across institutions that address scientific questions essential to improving women's health. To enhance the careers of SCORE trainees, the CEC will specifically: 1) Integrate levels of training and thought about etiologic mechanisms at basic and clinical levels for sex differences, and for gender and health disparities at the policy level. 2) Mentor trainees from a team perspective that exposes them to different levels of analysis from mentors with complementary expertise. 3) Provide access to material and faculty resources that will enhance the success of the initial group of candidates. The CEC infrastructure will provide a model that can be generalized to others in the future, playing a convening/integrative role in training the next generation across fields, methodologies and institutions. We are also committed to training a diverse biomedical workforce, as exemplified by the first set of participants and investigators included in this SCORE. Two junior faculty will serve as initial models for implementing this CEC based on their interests in sex differences in immune pathways in the brain, fetal programming and offspring brain development, and impact of pregnancy complications on offspring brain and cardiac function. Finally, we will (4) provide seed funding to supplement work with the preclinical studies and ultimately translate to the human studies. In summary, this core will create individually-tailored curricula that will take advantage of mentorship strengths across institutions and foster the professional skills of a next generation of rising stars for women's health research.

职业提升核心（CEC）将有助于培养下一代科学家， 临床医生-科学家是妇女健康和医学性别差异领域的领导者。他们将 增强能力，以帮助了解依赖性别的重大精神病和相关疾病的脆弱性 医学疾病我们的SCORE侧重于了解重度抑郁症和相关疾病的性别差异。 自主生理学和翻译这方面的知识到性别依赖疗法的发展。 定义性别的影响，除了性别，将准备我们的参与者考虑翻译的 将科学发现转化为政策和宣传。培养下一代认识性和性别的重要性 了解医学和医疗保健将是实现国家战略计划， 精准或个性化医疗。SCORE的教师有着悠久的历史，培养人们思考 医学中的性与性别我们将整合SCORE合作伙伴的培训基础设施， 为女性健康和性别疾病的差异提供新的机遇，扩大资源，增加新的 教师，并教育学员关于新技术和方法。CEC将利用 关于性别差异和妇女健康的跨学科研究合作的悠久传统， 这些机构的调查人员，包括以前的ORWH P50 SCOR，专注于性别差异 在HMS，CSU和亚利桑那大学的抑郁症中。我们为学员提供了 跨机构的大量生物医学资源，这些资源解决对改善人类健康至关重要的科学问题。 妇女的健康。为了提高SCORE学员的职业生涯，CEC将特别：1）整合 在基础和临床水平上对性别差异和性别差异的病因机制进行培训和思考 以及政策层面的健康差异。2)从团队的角度指导学员，让他们了解 来自具有互补专业知识的导师的不同层次的分析。3)提供获取材料的途径， 教师资源，这将提高候选人的初始组的成功。CEC基础设施将 提供一个未来可以推广的模式，在培训中发挥召集/整合作用 跨领域、跨方法和跨机构的下一代。我们还致力于培养多样化的 生物医学劳动力，如本评分中包含的第一批参与者和研究者所示。 两名初级教员将根据他们对性的兴趣作为实施这一社区教育方案的初步模式。 大脑中免疫途径的差异，胎儿编程和后代大脑发育，以及影响 妊娠并发症对后代大脑和心脏功能的影响。最后，我们将（4）提供种子资金， 临床前研究的补充工作，并最终转化为人体研究。总之，这 核心将创建个性化的课程，将利用导师优势， 该计划旨在加强妇女健康研究机构的能力建设，培养下一代妇女健康研究新星的专业技能。