Longitudinal Academic Performance in Children with a History of Neonatal Abstinence Syndrome

有新生儿戒断综合症病史的儿童的纵向学业表现

• 批准号: 10349927
• 负责人: Tammy E Corr
• 金额: $ 19.94万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10349927
• 关键词: 3 year old; Academic Medical Centers; Academic achievement; Accounting; Achievement; Adult; Affect; Age; Biological; Biometry; Caregivers; Caring; Child; Child Welfare; Childhood; Clinical Research; Communities; Community Health; Complement; Complex; Conduct Clinical Trials; Crime; Data; Databases; Development; Developmental Delay Disorders; Diagnosis; Drug Exposure; Early Intervention; Environment; Epidemiology; Family; Foundations; Future; Generations; Goals; Grant; Health; Healthcare; Illicit Drugs; Incidence; Individual; Infant; Influentials; Information Systems; Intervention; Intervention Studies; Interview; K-Series Research Career Programs; Learning; Link; Measures; Mentorship; Methodology; Methods; Mothers; Neonatal; Neonatal Abstinence Syndrome; Newborn Infant; Nursery Schools; Opioid; Outcome; Parents; Pennsylvania; Performance; Physicians; Policies; Pregnant Women; Problem behavior; Productivity; Public Health; Race; Recording of previous events; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resolution; Resources; Risk; School-Age Population; Schools; Scientist; Services; Severities; Social Environment; Social Welfare; Socioeconomic Factors; Special Education; Symptoms; Syndrome; Testing; Time; Toddler; Training; Translating; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Withdrawal; achievement test; career development; clinical practice; cost; data warehouse; design; diagnosis evaluation; drug exposure in utero; early childhood; effective intervention; experience; improved; improved outcome; in utero; inattention; neonate; neurodevelopment; opioid epidemic; patient oriented; postnatal; research and development; sex; success

Project Summary/Abstract The objectives of this project are to more thoroughly understand the relationship between neonatal abstinence syndrome (NAS) and longitudinal academic performance. NAS is a withdrawal condition due to in utero drug exposure, most commonly opioids. The syndrome affects more than 32,000 newborns annually in the U.S., and its incidence continues to rise. Researchers report poorer development in toddler and preschool years, higher rates of inattention and behavioral problems, and worse and deteriorating school performance in children with a history of NAS, indicating the effects of NAS may last well beyond the newborn period. However, these existing studies do not sufficiently account for the complex interaction of biologic, health, and socioenvironmental influences on childhood development. Thus, the relationship between NAS and long-term neurodevelopment and academic achievement remains largely unknown. As school achievement is directly associated with adult productivity and negatively correlated with participation in crime, a better understanding of NAS and academic performance is urgently needed to optimize outcomes across a lifetime. This proposal aims to assess the independent relationship between NAS, NAS severity, NAS treatment, in utero drug exposure and longitudinal academic performance after controlling for relevant biologic, health, and socioenvironmental variables; to explore the moderator effects of early community and school resource support on NAS; and to learn how families’ school experiences may explain childhood academic performance. The former aims will be accomplished using an inclusive, uniquely-integrated South Carolinian data warehouse. With this data system, a child with a diagnosis of NAS can be linked with his/her mother, and the dyad can be followed so that a broad range of childhood outcomes can be examined in the context of relevant, influential factors. In addition, through qualitative interviews with parents and guardians of children with a history of NAS followed at a Pennsylvania academic medical center, the project will 1) explore if and how caregivers’ experiences regarding early community and school resource support are related to childhood academic performance and 2) analyze themes that emerge around barriers and facilitators of academic achievement in children with NAS. Under this career development award, the applicant receives training in methodology of data-driven, public health studies and patient-oriented, clinical research design; epidemiology, mixed methodologies, community health, and applying public health principles to clinical practice; and moving research to policy. Successful completion of the project will not only provide data to serve as the foundation for future studies evaluating NAS outcomes and treatment, but, in addition to her training and mentorship plan, will prepare the applicant to become an independent physician-scientist able to conduct clinical trials aimed at improving outcomes of children affected by NAS.

项目总结/摘要 本项目的目标是更彻底地了解新生儿与 戒断综合征（NAS）和纵向学业成绩。NAS是一种停药条件， 子宫内药物暴露最常见的是阿片类药物这种综合征每年影响32，000多名新生儿， 美国，而且发病率还在持续上升研究人员报告说，幼儿和学龄前儿童的发育较差 年，注意力不集中和行为问题的发生率较高， 有NAS病史的儿童，表明NAS的影响可能会持续到新生儿期之后。 然而，这些现有的研究并没有充分说明生物、健康和 社会环境对儿童发展的影响。因此，NAS与长期 神经发育和学术成就在很大程度上仍然未知。因为学校成绩直接 与成年人的生产力相关，与参与犯罪呈负相关， NAS和学业成绩的重要性是迫切需要的，以优化整个一生的结果。 该提案旨在评估NAS、NAS严重程度、NAS治疗、 在控制相关生物学、健康和 社会环境变项;探讨早期社区与学校资源的调节效应 支持NAS;并了解家庭的学校经历如何解释儿童的学习成绩。 前一个目标将使用一个包容性的、综合性的南卡罗来纳数据来实现。 仓库有了这个数据系统，诊断为NAS的儿童可以与他/她的母亲联系起来， 可以遵循二元关系，以便在相关的背景下， 影响因素。此外，通过对患有自闭症儿童的父母和监护人的定性访谈， 该项目在宾夕法尼亚州学术医疗中心追踪NAS的历史，将1）探索是否以及如何 照顾者对早期社区和学校资源支持的经验与童年有关 学习成绩和2）分析围绕学术障碍和促进因素出现的主题 NAS儿童的成就。 在这个职业发展奖，申请人接受培训的方法，数据驱动，公共 健康研究和以病人为导向，临床研究设计;流行病学，混合方法，社区 健康，并将公共卫生原则应用于临床实践;并将研究转向政策。成功 该项目的完成，不仅可以为未来评估美国国家航空航天局的研究提供数据基础 结果和治疗，但是，除了她的培训和指导计划，将准备申请人， 成为一名独立的医生，科学家能够进行临床试验，旨在改善的结果 受NAS影响的儿童。